Literature DB >> 28406017

Templated Self-Assembly of a Covalent Polymer Network for Intracellular Protein Delivery and Traceless Release.

Kingshuk Dutta1, Ding Hu1, Bo Zhao1, Alexander E Ribbe1, Jiaming Zhuang1, S Thayumanavan1.   

Abstract

Trafficking proteins inside cells is an emerging field with potential utility in basic cell biology and biological therapeutics. A robust and sustainable delivery strategy demands not only good protection of the cargo but also reversibility in conjugation and activity. We report a protein-templated polymer self-assembly strategy for forming a sheath around the proteins and then tracelessly releasing them in the cytosol. The versatility of the approach, demonstrated here, suggests that the strategy is compatible with a wide array of biologics.

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Year:  2017        PMID： 28406017      PMCID： PMC5643195          DOI： 10.1021/jacs.7b01214

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  25 in total

1.  Protein-Polymer Hybrid Amphiphiles This research was supported by the Netherlands Foundation for Chemical Research (CW-NWO), the EC TMR Sisitomas and ESF Smarton programs, and the Ministerio de Educación y Cultura (Spain). The authors thank H. P. M. Geurts, P. J. H. M. Adams, and J. L. J. van Dongen for experimental assistance.

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Journal:  Mol Pharm       Date:  2010-08-02       Impact factor: 4.939

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Authors:  Benjamin Leader; Quentin J Baca; David E Golan
Journal:  Nat Rev Drug Discov       Date:  2008-01       Impact factor: 84.694

4.  Concurrent binding and delivery of proteins and lipophilic small molecules using polymeric nanogels.

Authors:  Daniella C González-Toro; Ja-Hyoung Ryu; Reuben T Chacko; Jiaming Zhuang; S Thayumanavan
Journal:  J Am Chem Soc       Date:  2012-04-11       Impact factor: 15.419

5.  Synthesis of Aminooxy End-functionalized pNIPAAm by RAFT Polymerization for Protein and Polysaccharide Conjugation.

Authors:  Vimary Vázquez-Dorbatt; Zachary P Tolstyka; Heather D Maynard
Journal:  Macromolecules       Date:  2009-10-27       Impact factor: 5.985

6.  Quantitative tracking of protein trafficking to the nucleus using cytosolic protein delivery by nanoparticle-stabilized nanocapsules.

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Journal:  Bioconjug Chem       Date:  2015-06-02       Impact factor: 4.774

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Journal:  J Biol Chem       Date:  1977-06-10       Impact factor: 5.157

8.  Reactive oxygen species-responsive protein modification and its intracellular delivery for targeted cancer therapy.

Authors:  Ming Wang; Shuo Sun; Caleb I Neufeld; Bernardo Perez-Ramirez; Qiaobing Xu
Journal:  Angew Chem Int Ed Engl       Date:  2014-10-06       Impact factor: 15.336

Review 9.  Stimuli-responsive nanomaterials for therapeutic protein delivery.

Authors:  Yue Lu; Wujin Sun; Zhen Gu
Journal:  J Control Release       Date:  2014-08-21       Impact factor: 9.776

10.  Self-Assembly of Temperature-Responsive Protein-Polymer Bioconjugates.

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Journal:  Bioconjug Chem       Date:  2015-07-02       Impact factor: 4.774
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  14 in total

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Authors:  Kacper Skakuj; Shuya Wang; Lei Qin; Andrew Lee; Bin Zhang; Chad A Mirkin
Journal:  J Am Chem Soc       Date:  2018-01-22       Impact factor: 15.419

2.  Reversible Click Chemistry for Ultrafast and Quantitative Formation of Protein-Polymer Nanoassembly and Intracellular Protein Delivery.

Authors:  Bin Liu; Margareta Ianosi-Irimie; S Thayumanavan
Journal:  ACS Nano       Date:  2019-07-26       Impact factor: 15.881

3.  Light: A Magical Tool for Controlled Drug Delivery.

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Journal:  Adv Funct Mater       Date:  2020-09-09       Impact factor: 18.808

4.  Charge-Conversion Strategies for Nucleic Acid Delivery.

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Journal:  Adv Funct Mater       Date:  2021-03-31       Impact factor: 19.924

5.  Nanogel-facilitated Protein Intracellular Specific Degradation through Trim-Away.

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Journal:  Adv Funct Mater       Date:  2021-05-18       Impact factor: 19.924

6.  Multiplexed Analysis of the Cellular Uptake of Polymeric Nanocarriers.

Authors:  Dheeraj K Agrohia; Peidong Wu; Uyen Huynh; S Thayumanavan; Richard W Vachet
Journal:  Anal Chem       Date:  2022-05-25       Impact factor: 8.008

7.  Cross-Linked Aptamer-Lipid Micelles for Excellent Stability and Specificity in Target-Cell Recognition.

Authors:  Xiaowei Li; C Adrian Figg; Ruowen Wang; Ying Jiang; Yifan Lyu; Hao Sun; Yuan Liu; Yanyue Wang; I-Ting Teng; Weijia Hou; Ren Cai; Cheng Cui; Long Li; Xiaoshu Pan; Brent S Sumerlin; Weihong Tan
Journal:  Angew Chem Int Ed Engl       Date:  2018-08-06       Impact factor: 15.336

Review 8.  Accessing Intracellular Targets through Nanocarrier-Mediated Cytosolic Protein Delivery.

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Journal:  Trends Pharmacol Sci       Date:  2020-09-02       Impact factor: 14.819

9.  Synergistic Interplay of Covalent and Non-Covalent Interactions in Reactive Polymer Nanoassembly Facilitates Intracellular Delivery of Antibodies.

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Journal:  Angew Chem Int Ed Engl       Date:  2020-11-19       Impact factor: 15.336

10.  In Situ Forming Injectable Thermoresponsive Hydrogels for Controlled Delivery of Biomacromolecules.

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Journal:  ACS Omega       Date:  2020-07-09
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