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Literature DB >> 28406012

Immunomodulatory Magnetic Microspheres for Augmenting Tumor-Specific Infiltration of Natural Killer (NK) Cells.

Wooram Park¹, Andrew C Gordon¹, Soojeong Cho¹, Xiaoke Huang¹, Kathleen R Harris¹, Andrew C Larson^1,2, Dong-Hyun Kim^1,2.

Abstract

The purpose of this research is to develop magnetic resonance imaging (MRI) visible immunomodulatory microspheres (IMM-MS) for efficient image guided cancer immunotherapy. IMM-MS composed of recombinant interferon gamma (IFN-γ), iron oxide nanocubes (IONC), and biodegradable poly(lactide-co-glycolide) (PLGA) were successfully prepared via a double-emulsion method. The prepared IMM-MS exhibited a sustained IFN-γ release and highly sensitive MR T2 contrast effects. Finally, in an orthotopic liver tumor VX2 rabbit model, successful hepatic intra-arterial (IA) transcatheter delivery of IMM-MS to liver tumors was confirmed with MR images. The deposition of IMM-MS significantly increased NK-cell infiltration into the liver tumor site.

Entities: Chemical Disease Gene Species

Keywords: and image-guided therapy; cancer immunotherapy; interferon-gamma (IFN-γ); microspheres; natural killer (NK) cells infiltration

Mesh：

Substances：
Interferon-gamma

Year: 2017 PMID： 28406012 PMCID： PMC5719880 DOI： 10.1021/acsami.7b02258

Source DB: PubMed Journal: ACS Appl Mater Interfaces ISSN： 1944-8244 Impact factor: 9.229

27 in total

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Journal: ACS Appl Mater Interfaces Date: 2016-05-16 Impact factor: 9.229

2. CXCL10-induced migration of adoptively transferred human natural killer cells toward solid tumors causes regression of tumor growth in vivo.

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4. Ultra-large-scale syntheses of monodisperse nanocrystals.

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5. IFN-gamma acts on T cells to induce NK cell mobilization and accumulation in target organs.

Authors: Ori Wald; Ido D Weiss; Hanna Wald; Hadas Shoham; Yochay Bar-Shavit; Katia Beider; Eithan Galun; Lola Weiss; Liat Flaishon; Idit Shachar; Arnon Nagler; Bao Lu; Craig Gerard; Ji-Liang Gao; Eyal Mishani; Joshua Farber; Amnon Peled
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6. Targeting Androgen Receptor (AR)→IL12A Signal Enhances Efficacy of Sorafenib plus NK Cells Immunotherapy to Better Suppress HCC Progression.

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Review 7. Targeting natural killer cells in cancer immunotherapy.

Authors: Camille Guillerey; Nicholas D Huntington; Mark J Smyth
Journal: Nat Immunol Date: 2016-08-19 Impact factor: 25.606

8. Quantitative functional MRI in a clinical orthotopic model of pancreatic cancer in immunocompetent Lewis rats.

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9. Efficacy of transcatheter arterial chemoembolization combined with cytokine-induced killer cell therapy on hepatocellular carcinoma: a comparative study.

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10. Percutaneous ultrasound guided implantation of VX2 for creation of a rabbit hepatic tumor model.

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16 in total

1. Development and Validation of Sorafenib-eluting Microspheres to Enhance Therapeutic Efficacy of Transcatheter Arterial Chemoembolization in a Rat Model of Hepatocellular Carcinoma.

Authors: Wooram Park; Soojeong Cho; Jingran Ji; Robert J Lewandowski; Andrew C Larson; Dong-Hyun Kim
Journal: Radiol Imaging Cancer Date: 2021-01-08

2. Advanced smart-photosensitizers for more effective cancer treatment.

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Journal: Biomater Sci Date: 2017-12-19 Impact factor: 6.843

3. Comparison of anesthesia and tumor implantation methods for establishing rabbit VX2 hepatocarcinoma.

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Journal: Am J Transl Res Date: 2019-11-15 Impact factor: 4.060

4. Multifunctional Nanocarriers-Mediated Synergistic Combination of Immune Checkpoint Inhibitor Cancer Immunotherapy and Interventional Oncology Therapy.

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5. PLGA Microspheres Containing Hydrophobically Modified Magnesium Hydroxide Particles for Acid Neutralization-Mediated Anti-Inflammation.

Authors: Joon-Kyu Kim; Eun-Jin Go; Kyoung-Won Ko; Hyeon-Ji Oh; Jieun Han; Dong Keun Han; Wooram Park
Journal: Tissue Eng Regen Med Date: 2021-04-20 Impact factor: 4.169