Literature DB >> 28403795

Mesenchymal Stem Cell-derived Extracellular Vesicles for Renal Repair.

Arash Aghajani Nargesi, Lilach O Lerman, Alfonso Eirin1.   

Abstract

INTRODUCTION: Transplantation of autologous mesenchymal stem cells (MSCs) has been shown to attenuate renal injury and dysfunction in several animal models, and its efficacy is currently being tested in clinical trials for patients with renal disease. Accumulating evidence indicates that MSCs release extracellular vesicles (EVs) that deliver genes, microRNAs and proteins to recipient cells, acting as mediators of MSC paracrine actions. In this context, it is critical to characterize the MSC-derived EV cargo to elucidate their potential contribution to renal repair. In recent years, researchers have performed high-throughput sequencing and proteomic analysis to detect and identify genes, microRNAs, and proteins enriched in MSC-derived EVs.
CONCLUSION: The present review summarizes the current knowledge of the MSC-derived EV secretome to shed light into the mechanisms mediating MSC renal repair, and discusses preclinical and clinical studies testing the efficacy of MSC-derived EVs for treating renal disease. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Entities:  

Keywords:  Exosomes; extracellular vesicles; kidney; mesenchymal stem cells; microRNA; microvesicles

Mesh：

Year:  2017        PMID： 28403795      PMCID： PMC5628022          DOI： 10.2174/1566523217666170412110724

Source DB:  PubMed          Journal:  Curr Gene Ther        ISSN： 1566-5232            Impact factor:   4.391


  100 in total

1.  Micro-vesicles derived from bone marrow stem cells protect the kidney both in vivo and in vitro by microRNA-dependent repairing.

Authors:  Juan He; Yan Wang; Xingyan Lu; Bei Zhu; Xiaohua Pei; Jianqing Wu; Weihong Zhao
Journal:  Nephrology (Carlton)       Date:  2015-09       Impact factor: 2.506

Review 2.  Rationale of mesenchymal stem cell therapy in kidney injury.

Authors:  Susanne V Fleig; Benjamin D Humphreys
Journal:  Nephron Clin Pract       Date:  2014-09-24

3.  [Bone marrow mesenchymal stem cell-derived exosome protects kidney against ischemia reperfusion injury in rats].

Authors:  Rulin Wang; Miao Lin; Liping Li; Long Li; Guisheng Qi; Ruiming Rong; Ming Xu; Tongyu Zhu
Journal:  Zhonghua Yi Xue Za Zhi       Date:  2014-11-18

4.  Microvesicles derived from human adult mesenchymal stem cells protect against ischaemia-reperfusion-induced acute and chronic kidney injury.

Authors:  Stefano Gatti; Stefania Bruno; Maria Chiara Deregibus; Andrea Sordi; Vincenzo Cantaluppi; Ciro Tetta; Giovanni Camussi
Journal:  Nephrol Dial Transplant       Date:  2011-02-15       Impact factor: 5.992

Review 5.  Systematic review and meta-analysis of mesenchymal stem/stromal cells therapy for impaired renal function in small animal models.

Authors:  Yan Wang; Juan He; Xiaohua Pei; Weihong Zhao
Journal:  Nephrology (Carlton)       Date:  2013-03       Impact factor: 2.506

6.  Different populations and sources of human mesenchymal stem cells (MSC): A comparison of adult and neonatal tissue-derived MSC.

Authors:  Ralf Hass; Cornelia Kasper; Stefanie Böhm; Roland Jacobs
Journal:  Cell Commun Signal       Date:  2011-05-14       Impact factor: 5.712

7.  Exosomes derived from mesenchymal stem cells suppress angiogenesis by down-regulating VEGF expression in breast cancer cells.

Authors:  Jong-Kuen Lee; Sae-Ra Park; Bong-Kwang Jung; Yoon-Kyung Jeon; Yeong-Shin Lee; Min-Kyoung Kim; Yong-Goo Kim; Ji-Young Jang; Chul-Woo Kim
Journal:  PLoS One       Date:  2013-12-31       Impact factor: 3.240

8.  MSC surface markers (CD44, CD73, and CD90) can identify human MSC-derived extracellular vesicles by conventional flow cytometry.

Authors:  Teresa L Ramos; Luis Ignacio Sánchez-Abarca; Sandra Muntión; Silvia Preciado; Noemí Puig; Guillermo López-Ruano; Ángel Hernández-Hernández; Alba Redondo; Rebeca Ortega; Concepción Rodríguez; Fermín Sánchez-Guijo; Consuelo del Cañizo
Journal:  Cell Commun Signal       Date:  2016-01-12       Impact factor: 5.712

9.  Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs.

Authors:  Donald G Phinney; Michelangelo Di Giuseppe; Joel Njah; Ernest Sala; Sruti Shiva; Claudette M St Croix; Donna B Stolz; Simon C Watkins; Y Peter Di; George D Leikauf; Jay Kolls; David W H Riches; Giuseppe Deiuliis; Naftali Kaminski; Siddaraju V Boregowda; David H McKenna; Luis A Ortiz
Journal:  Nat Commun       Date:  2015-10-07       Impact factor: 14.919

10.  Exosomal miR-223 Contributes to Mesenchymal Stem Cell-Elicited Cardioprotection in Polymicrobial Sepsis.

Authors:  Xiaohong Wang; Haitao Gu; Dongze Qin; Liwang Yang; Wei Huang; Kobina Essandoh; Yigang Wang; Charles C Caldwell; Tianqing Peng; Basilia Zingarelli; Guo-Chang Fan
Journal:  Sci Rep       Date:  2015-09-08       Impact factor: 4.379
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  41 in total

Review 1.  Novel therapeutic strategies for renovascular disease.

Authors:  Alfonso Eirin; Stephen C Textor; Lilach O Lerman
Journal:  Curr Opin Nephrol Hypertens       Date:  2019-07       Impact factor: 2.894

Review 2.  Atherosclerotic-nephropathy: an updated narrative review.

Authors:  Mariadelina Simeoni; Silvio Borrelli; Carlo Garofalo; Giorgio Fuiano; Ciro Esposito; Alessandro Comi; Michele Provenzano
Journal:  J Nephrol       Date:  2020-04-08       Impact factor: 3.902

Review 3.  Stem cell extracellular vesicles and kidney injury.

Authors:  Cristina Grange; Corinne Iampietro; Benedetta Bussolati
Journal:  Stem Cell Investig       Date:  2017-11-16

Review 4.  Mesenchymal Stem Cells on Horizon: A New Arsenal of Therapeutic Agents.

Authors:  Zahra Abbasi-Malati; Amaneh Mohammadi Roushandeh; Yoshikazu Kuwahara; Mehryar Habibi Roudkenar
Journal:  Stem Cell Rev Rep       Date:  2018-08       Impact factor: 5.739

5.  The Therapeutic Potential of Extracellular Vesicles Versus Mesenchymal Stem Cells in Liver Damage.

Authors:  Dina M Rostom; Noha Attia; Hoda M Khalifa; Maha W Abou Nazel; Eshrak A El Sabaawy
Journal:  Tissue Eng Regen Med       Date:  2020-06-06       Impact factor: 4.169

Review 6.  Stem cell-derived extracellular vesicles for renal repair: do cardiovascular comorbidities matter?

Authors:  Alfonso Eirin; Lilach O Lerman
Journal:  Am J Physiol Renal Physiol       Date:  2019-10-21

7.  Human peripheral blood-derived mesenchymal stem cells with NTRK1 over-expression enhance repairing capability in a rat model of Parkinson's disease.

Authors:  Kun Liu; Wei Zhang; Yunlong Li; Qingfeng Ding; Yunan Bai; Fachen Wang; Guangming Xu
Journal:  Cytotechnology       Date:  2018-07-05       Impact factor: 2.058

8.  Mesenchymal Stem/Stromal Cells and their Extracellular Vesicle Progeny Decrease Injury in Poststenotic Swine Kidney Through Different Mechanisms.

Authors:  Yu Zhao; Xiangyang Zhu; Lei Zhang; Christopher M Ferguson; Turun Song; Kai Jiang; Sabena M Conley; James D Krier; Hui Tang; Ishran Saadiq; Kyra L Jordan; Amir Lerman; Lilach O Lerman
Journal:  Stem Cells Dev       Date:  2020-08-03       Impact factor: 3.272

9.  Urinary vitronectin identifies patients with high levels of fibrosis in kidney grafts.

Authors:  Laura Carreras-Planella; David Cucchiari; Laura Cañas; Javier Juega; Marcella Franquesa; Josep Bonet; Ignacio Revuelta; Fritz Diekmann; Omar Taco; Ricardo Lauzurica; Francesc Enric Borràs
Journal:  J Nephrol       Date:  2020-12-04       Impact factor: 3.902

Review 10.  Recent Advances in Understandings Towards Pathogenesis and Treatment for Intrauterine Adhesion and Disruptive Insights from Single-Cell Analysis.

Authors:  Ross Ka-Kit Leung; Yixin Lin; Yanhui Liu
Journal:  Reprod Sci       Date:  2020-10-30       Impact factor: 3.060
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