OBJECTIVE: In the 29 years since the initial description of Modic type 1 vertebral endplate changes there has been ongoing debate regarding their cause. Studies have attributed Modic type 1 vertebral endplate changes to traumatic injury to the vertebral endplate, localized action of proinflammatory mediators, and more recently low-grade bacterial infection. Can we reconcile these conflicting data about the underlying cause of Modic type 1 vertebral endplate changes? Are we now in a position to conclude whether Modic type 1 vertebral endplate changes are secondary to injury, inflammation, or infection? CONCLUSION: We argue that the processes are not disparate but are in fact closely linked, each potentially instigating a chain of events leading to the MRI findings of Modic type 1 vertebral endplate change. A method of delineating which process is predominantly at play in an individual patient is required so that tailored treatment options can be offered with huge potential benefit to individuals and society alike.
OBJECTIVE: In the 29 years since the initial description of Modic type 1 vertebral endplate changes there has been ongoing debate regarding their cause. Studies have attributed Modic type 1 vertebral endplate changes to traumatic injury to the vertebral endplate, localized action of proinflammatory mediators, and more recently low-grade bacterial infection. Can we reconcile these conflicting data about the underlying cause of Modic type 1 vertebral endplate changes? Are we now in a position to conclude whether Modic type 1 vertebral endplate changes are secondary to injury, inflammation, or infection? CONCLUSION: We argue that the processes are not disparate but are in fact closely linked, each potentially instigating a chain of events leading to the MRI findings of Modic type 1 vertebral endplate change. A method of delineating which process is predominantly at play in an individual patient is required so that tailored treatment options can be offered with huge potential benefit to individuals and society alike.
Authors: Aleksandra Sadowska; Ermioni Touli; Wolfgang Hitzl; Helen Greutert; Stephen J Ferguson; Karin Wuertz-Kozak; Oliver N Hausmann Journal: Eur Spine J Date: 2017-12-04 Impact factor: 3.134
Authors: Peter Fritzell; Christina Welinder-Olsson; Bodil Jönsson; Åsa Melhus; Siv G E Andersson; Tomas Bergström; Hans Tropp; Paul Gerdhem; Olle Hägg; Hans Laestander; Björn Knutsson; Anders Lundin; Per Ekman; Eric Rydman; Mikael Skorpil Journal: Eur Spine J Date: 2019-10-01 Impact factor: 3.134
Authors: Juan Esteban Muñoz Montoya; Carlos Pérez Cataño; Angela María Tapicha Cuellar; Maria Paula Vargas Osorio; Jimar Rivero Cano; Juan Carlos Luque Suarez; Marco Luciano Charry Lopez Journal: J Spine Surg Date: 2018-09