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Literature DB >> 2840183

Interaction of cadmium ions with calcium hydroxyapatite crystals: a possible mechanism contributing to the pathogenesis of cadmium-induced bone diseases.

J Christoffersen¹, M R Christoffersen, R Larsen, E Rostrup, P Tingsgaard, O Andersen, P Grandjean.

Abstract

Cadmium ions adsorb onto calcium hydroxyapatite crystals (HA) and are as effective as inorganic pyrophosphate and aluminum ions in retarding the rate of in vitro dissolution of HA. In contrast, cadmium ions have no important retarding effect on the growth of HA, but are built into the crystals, thus making them very resistant to subsequent dissolution. These effects could interfere with bone remodeling, with cadmium protecting normal sites of resorption and thus causing resorption at pathological sites.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1988 PMID： 2840183 DOI： 10.1007/BF02556369

Source DB: PubMed Journal: Calcif Tissue Int ISSN： 0171-967X Impact factor: 4.333

15 in total

1. Disturbances in kidney functions and calcium and phosphate metabolism in cadmium-poisoned rats.

Authors: J Kawamura; O Yoshida; K Nishino; Y Itokawa
Journal: Nephron Date: 1978 Impact factor: 2.847

2. Renal and skeletal lesions in experimental cadmium poisoning: histological and biochemical approaches.

Authors: Y Itokawa; T Abe; R Tabei; S Tanaka
Journal: Arch Environ Health Date: 1974-03

3. The inhibitory effects of ATP, ADP, and AMP on the rate of dissolution of calcium hydroxyapatite.

Authors: M R Christoffersen; J Christoffersen
Journal: Calcif Tissue Int Date: 1984-12 Impact factor: 4.333

4. Urine analysis for detection of cadmium-induced renal changes, with special reference to beta2-microglobulin. A cooperative study between Japan and Sweden.

Authors: K Shiroishi; T Kjellström; K Kubota; P E Evrin; M Anayama; O Vesterberg; T Shimada; M Piscator; T Iwata; H Nishino
Journal: Environ Res Date: 1977-06 Impact factor: 6.498

5. Effect of cadmium administration on intestinal calcium absorption and vitamin D-dependent calcium-binding protein.

Authors: C S Fullmer; T Oku; R H Wasserman
Journal: Environ Res Date: 1980-08 Impact factor: 6.498

6. Influence of poisonous metals on bone metabolism. III. The effect of cadmium on bone resorption in tissue culture.

Authors: T Miyahara; M Miyakoshi; Y Saito; H Kozuka
Journal: Toxicol Appl Pharmacol Date: 1980-09-30 Impact factor: 4.219

7. The effect of aluminum on the rate of dissolution of calcium hydroxyapatite--a contribution to the understanding of aluminum-induced bone diseases.

Authors: M R Christoffersen; J Christoffersen
Journal: Calcif Tissue Int Date: 1985-12 Impact factor: 4.333

Interaction of cadmium ions with calcium hydroxyapatite crystals: a possible mechanism contributing to the pathogenesis of cadmium-induced bone diseases.

1. Disturbances in kidney functions and calcium and phosphate metabolism in cadmium-poisoned rats.

2. Renal and skeletal lesions in experimental cadmium poisoning: histological and biochemical approaches.

3. The inhibitory effects of ATP, ADP, and AMP on the rate of dissolution of calcium hydroxyapatite.

4. Urine analysis for detection of cadmium-induced renal changes, with special reference to beta2-microglobulin. A cooperative study between Japan and Sweden.

5. Effect of cadmium administration on intestinal calcium absorption and vitamin D-dependent calcium-binding protein.

6. Influence of poisonous metals on bone metabolism. III. The effect of cadmium on bone resorption in tissue culture.

7. The effect of aluminum on the rate of dissolution of calcium hydroxyapatite--a contribution to the understanding of aluminum-induced bone diseases.

8. Vitamin D metabolism in adult rats at low and normal calcium intake and the effect of cadmium exposure.

9. Interaction between calcium and cadmium in the 1,25-dihydroxyvitamin D3 stimulated rat duodenum.

10. Cadmium and the kidney.

1. The effect of gallium on seeded hydroxyapatite growth.

2. A quantitative study of iliac bone histopathology on 62 cases with itai-itai disease.

3. Changes in compact bone microstructure of rats subchronically exposed to cadmium.