Eungseok Oh1, Jinse Park2, Jinyoung Youn3, Ji Sun Kim4, Suyeon Park5, Wooyoung Jang6. 1. Department of Neurology, Chungnam National University College of Medicine, Chungnam National University Hospital, Daejeon, Republic of Korea. 2. Department of Neurology, Inje University, Haeundae Paik Hospital, Busan, Republic of Korea. 3. Department of Neurology, Samsung Medical Center, Seoul, Republic of Korea. 4. Department of Neurology, Soonchunhyang University Hospital, Seoul, Republic of Korea. 5. Department of Biostatistics, Soonchunhyang University Hospital, Seoul, Republic of Korea. 6. Department of Neurology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Republic of Korea. Electronic address: neveu@gnah.co.kr.
Abstract
OBJECTIVE: Our study aimed to determine whether the short latency afferent inhibition (SAI) response could be associated with the severity of olfactory dysfunction in PD patients. METHODS: A total of 71 PD patients and 20 controls were enrolled. All PD patients were classified into 3 groups by the severity of the olfactory deficit. Single-pulse transmagnetic stimulation (TMS) parameters and SAI were assessed. RESULTS: The integrated SAI in the PD with anosmia and PD with hyposomia groups was significantly less inhibited than that in the PD with normosmia and control groups [64.79 {Interquartile range (IQR): 59.96, 71.33}, 84.79 {IQR: 75.03, 90.63} versus 36.72 {IQR: 32.28, 48.33}, 42.15 {IQR: 34.60, 44.96}, respectively]. In PD subjects, the severity of olfactory dysfunction also showed a significant negative correlation with the SAI response (r=-0.829, p<0.001). CONCLUSIONS: Considering that the SAI response partly reflects central cholinergic dysfunction and that our study shows a relationship between the SAI response and the severity of olfactory dysfunction in PD, our findings indicate that cholinergic dysfunction could possibly contribute to the pathogenesis of olfactory dysfunction in early PD. SIGNIFICANCE: SAI could be a useful marker to detect severe olfactory dysfunction in PD.
OBJECTIVE: Our study aimed to determine whether the short latency afferent inhibition (SAI) response could be associated with the severity of olfactory dysfunction in PDpatients. METHODS: A total of 71 PDpatients and 20 controls were enrolled. All PDpatients were classified into 3 groups by the severity of the olfactory deficit. Single-pulse transmagnetic stimulation (TMS) parameters and SAI were assessed. RESULTS: The integrated SAI in the PD with anosmia and PD with hyposomia groups was significantly less inhibited than that in the PD with normosmia and control groups [64.79 {Interquartile range (IQR): 59.96, 71.33}, 84.79 {IQR: 75.03, 90.63} versus 36.72 {IQR: 32.28, 48.33}, 42.15 {IQR: 34.60, 44.96}, respectively]. In PD subjects, the severity of olfactory dysfunction also showed a significant negative correlation with the SAI response (r=-0.829, p<0.001). CONCLUSIONS: Considering that the SAI response partly reflects central cholinergic dysfunction and that our study shows a relationship between the SAI response and the severity of olfactory dysfunction in PD, our findings indicate that cholinergic dysfunction could possibly contribute to the pathogenesis of olfactory dysfunction in early PD. SIGNIFICANCE: SAI could be a useful marker to detect severe olfactory dysfunction in PD.
Keywords:
Cholinergic system; Korean version of the Sniffin' stick test (KVSS); Olfaction; Parkinson’s disease; Short latency afferent inhibition (SAI)
Authors: Swati Rane; Natalie Koh; John Oakley; Christina Caso; Cyrus P Zabetian; Brenna Cholerton; Thomas J Montine; Thomas Grabowski Journal: Parkinsonism Relat Disord Date: 2020-05-11 Impact factor: 4.891