Literature DB >> 28388427

The NextGen Genetic Association Studies Consortium: A Foray into In Vitro Population Genetics.

Curtis R Warren1, Cashell E Jaquish2, Chad A Cowan3.   

Abstract

The National Heart, Lung, and Blood Institute's Next Generation Genetic Association Studies Consortium has used induced pluripotent stem cell technology to study the effects of common genetic variants in vitro. This issue of Cell Stem Cell and affiliated journals include several manuscripts describing the results of the consortium's efforts.
Copyright © 2017. Published by Elsevier Inc.

Keywords:  Community Cohort Study; NHLBI; Next Generation Genetic Association Studies Consortium; cardiovascular disease; genome editing; humanity in a dish; iPSC; polygenic disease; population genetics; quantitative trait locus

Mesh：

Year:  2017        PMID： 28388427     DOI： 10.1016/j.stem.2017.03.021

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   24.633


  14 in total

1.  [Leukocyte count of puerperal sows].

Authors:  D Mäde; G Wujanz
Journal:  Berl Munch Tierarztl Wochenschr       Date:  1996-09       Impact factor: 0.328

Review 2.  Modeling schizophrenia pathogenesis using patient-derived induced pluripotent stem cells (iPSCs).

Authors:  Haneul Noh; Zhicheng Shao; Joseph T Coyle; Sangmi Chung
Journal:  Biochim Biophys Acta Mol Basis Dis       Date:  2017-06-28       Impact factor: 5.187

3.  Functional Screening of Candidate Causal Genes for Insulin Resistance in Human Preadipocytes and Adipocytes.

Authors:  Zhifen Chen; Haojie Yu; Xu Shi; Curtis R Warren; Luca A Lotta; Max Friesen; Torsten B Meissner; Claudia Langenberg; Martin Wabitsch; Nick Wareham; Mark D Benson; Rob E Gerszten; Chad A Cowan
Journal:  Circ Res       Date:  2019-11-19       Impact factor: 17.367

Review 4.  Stem Cells, Genome Editing, and the Path to Translational Medicine.

Authors:  Frank Soldner; Rudolf Jaenisch
Journal:  Cell       Date:  2018-10-18       Impact factor: 41.582

5.  Systems-Wide Approaches in Induced Pluripotent Stem Cell Models.

Authors:  Edward Lau; David T Paik; Joseph C Wu
Journal:  Annu Rev Pathol       Date:  2018-10-31       Impact factor: 23.472

Review 6.  Patient derived stem cells for discovery and validation of novel pathogenic variants in inherited retinal disease.

Authors:  Nathaniel K Mullin; Andrew P Voigt; Jessica A Cooke; Laura R Bohrer; Erin R Burnight; Edwin M Stone; Robert F Mullins; Budd A Tucker
Journal:  Prog Retin Eye Res       Date:  2020-10-29       Impact factor: 21.198

7.  Molecular and functional variation in iPSC-derived sensory neurons.

Authors:  Jeremy Schwartzentruber; Stefanie Foskolou; Helena Kilpinen; Julia Rodrigues; Kaur Alasoo; Andrew J Knights; Minal Patel; Angela Goncalves; Rita Ferreira; Caroline Louise Benn; Anna Wilbrey; Magda Bictash; Emma Impey; Lishuang Cao; Sergio Lainez; Alexandre Julien Loucif; Paul John Whiting; Alex Gutteridge; Daniel J Gaffney
Journal:  Nat Genet       Date:  2017-12-11       Impact factor: 38.330

Review 8.  The Expanding Landscape of Alternative Splicing Variation in Human Populations.

Authors:  Eddie Park; Zhicheng Pan; Zijun Zhang; Lan Lin; Yi Xing
Journal:  Am J Hum Genet       Date:  2018-01-04       Impact factor: 11.025

9.  Understanding the genetics behind complex human disease with large-scale iPSC collections.

Authors:  Amanda E Yamasaki; Athanasia D Panopoulos; Juan Carlos Izpisua Belmonte
Journal:  Genome Biol       Date:  2017-07-20       Impact factor: 13.583

Review 10.  New considerations for hiPSC-based models of neuropsychiatric disorders.

Authors:  Gabriel E Hoffman; Nadine Schrode; Erin Flaherty; Kristen J Brennand
Journal:  Mol Psychiatry       Date:  2018-02-26       Impact factor: 15.992
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