Literature DB >> 28668333

Modeling schizophrenia pathogenesis using patient-derived induced pluripotent stem cells (iPSCs).

Haneul Noh1, Zhicheng Shao1, Joseph T Coyle2, Sangmi Chung3.   

Abstract

Schizophrenia is a chronic disabling mental disorder that affects about 1% population world-wide, for which there is a desperate need to develop more effective treatments. In this minireview, we summarize the findings from recent studies using induced pluripotent stem cells to model the developmental pathogenesis of schizophrenia and discuss what we have learned from these studies. We also discuss what are the important next steps and key issues to be addressed to move the field forward.
Copyright © 2017 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Differentiation; Neural progenitor cell; Schizophrenia; iPSC

Mesh：

Year:  2017        PMID： 28668333      PMCID： PMC5737829          DOI： 10.1016/j.bbadis.2017.06.019

Source DB:  PubMed          Journal:  Biochim Biophys Acta Mol Basis Dis        ISSN： 0925-4439            Impact factor:   5.187


  78 in total

Review 1.  The neurodevelopmental hypothesis of schizophrenia: convergent clues from epidemiology and neuropathology.

Authors:  Michael Piper; Monica Beneyto; Thomas H J Burne; Darryl W Eyles; David A Lewis; John J McGrath
Journal:  Psychiatr Clin North Am       Date:  2012-07-15

2.  Common developmental genome deprogramming in schizophrenia - Role of Integrative Nuclear FGFR1 Signaling (INFS).

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Journal:  Schizophr Res       Date:  2017-01-13       Impact factor: 4.939

3.  Reducing prefrontal gamma-aminobutyric acid activity induces cognitive, behavioral, and dopaminergic abnormalities that resemble schizophrenia.

Authors:  Takeshi Enomoto; Maric T Tse; Stan B Floresco
Journal:  Biol Psychiatry       Date:  2010-12-10       Impact factor: 13.382

Review 4.  Imaging dopamine transmission in schizophrenia. A review and meta-analysis.

Authors:  M Laruelle
Journal:  Q J Nucl Med       Date:  1998-09

5.  Subunit-selective modulation of GABA type A receptor neurotransmission and cognition in schizophrenia.

Authors:  David A Lewis; Raymond Y Cho; Cameron S Carter; Kevin Eklund; Sarah Forster; Mary Ann Kelly; Debra Montrose
Journal:  Am J Psychiatry       Date:  2008-10-15       Impact factor: 18.112

Review 6.  Early developmental disturbances of cortical inhibitory neurons: contribution to cognitive deficits in schizophrenia.

Authors:  David W Volk; David A Lewis
Journal:  Schizophr Bull       Date:  2014-07-22       Impact factor: 9.306

Review 7.  Calcium binding protein markers of GABA deficits in schizophrenia--postmortem studies and animal models.

Authors:  Gavin P Reynolds; Zuhal Abdul-Monim; Joanna C Neill; Zhi-Jun Zhang
Journal:  Neurotox Res       Date:  2004       Impact factor: 3.911

8.  Abnormal neuronal differentiation and mitochondrial dysfunction in hair follicle-derived induced pluripotent stem cells of schizophrenia patients.

Authors:  O Robicsek; R Karry; I Petit; N Salman-Kesner; F-J Müller; E Klein; D Aberdam; D Ben-Shachar
Journal:  Mol Psychiatry       Date:  2013-06-04       Impact factor: 15.992

9.  Scientific and consumer models of recovery in schizophrenia: concordance, contrasts, and implications.

Authors:  Alan S Bellack
Journal:  Schizophr Bull       Date:  2006-02-03       Impact factor: 9.306

10.  Analysis of induced pluripotent stem cells carrying 22q11.2 deletion.

Authors:  M Toyoshima; W Akamatsu; Y Okada; T Ohnishi; S Balan; Y Hisano; Y Iwayama; T Toyota; T Matsumoto; N Itasaka; S Sugiyama; M Tanaka; M Yano; B Dean; H Okano; T Yoshikawa
Journal:  Transl Psychiatry       Date:  2016-11-01       Impact factor: 6.222
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  6 in total

1.  Transcriptomic and epigenomic dynamics associated with development of human iPSC-derived GABAergic interneurons.

Authors:  George Andrew S Inglis; Ying Zhou; Dillon G Patterson; Christopher D Scharer; Yanfei Han; Jeremy M Boss; Zhexing Wen; Andrew Escayg
Journal:  Hum Mol Genet       Date:  2020-08-29       Impact factor: 6.150

2.  Comprehensive and integrative analyses identify TYW5 as a schizophrenia risk gene.

Authors:  Chengcheng Zhang; Xiaojing Li; Liansheng Zhao; Rong Liang; Wei Deng; Wanjun Guo; Qiang Wang; Xun Hu; Xiangdong Du; Pak Chung Sham; Xiongjian Luo; Tao Li
Journal:  BMC Med       Date:  2022-05-09       Impact factor: 11.150

Review 3.  Drugs Based on NMDAR Hypofunction Hypothesis in Schizophrenia.

Authors:  Qiongqiong Wu; Jing Huang; Renrong Wu
Journal:  Front Neurosci       Date:  2021-04-12       Impact factor: 4.677

Review 4.  hiPSCs for predictive modelling of neurodegenerative diseases: dreaming the possible.

Authors:  Pia Rivetti di Val Cervo; Dario Besusso; Paola Conforti; Elena Cattaneo
Journal:  Nat Rev Neurol       Date:  2021-03-03       Impact factor: 42.937

5.  Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell-derived cortical interneurons from subjects with schizophrenia.

Authors:  Zhicheng Shao; Haneul Noh; Woong Bin Kim; Peiyan Ni; Christine Nguyen; Sarah E Cote; Elizabeth Noyes; Joyce Zhao; Teagan Parsons; James M Park; Kelvin Zheng; Joshua J Park; Joseph T Coyle; Daniel R Weinberger; Richard E Straub; Karen F Berman; Jose Apud; Dost Ongur; Bruce M Cohen; Donna L McPhie; Judith L Rapoport; Roy H Perlis; Thomas A Lanz; Hualin Simon Xi; Changhong Yin; Weihua Huang; Teruyoshi Hirayama; Emi Fukuda; Takeshi Yagi; Sulagna Ghosh; Kevin C Eggan; Hae-Young Kim; Leonard M Eisenberg; Alexander A Moghadam; Patric K Stanton; Jun-Hyeong Cho; Sangmi Chung
Journal:  Nat Neurosci       Date:  2019-01-21       Impact factor: 24.884

6.  Activated microglia cause metabolic disruptions in developmental cortical interneurons that persist in interneurons from individuals with schizophrenia.

Authors:  Gun-Hoo Park; Haneul Noh; Zhicheng Shao; Peiyan Ni; Yiren Qin; Dongxin Liu; Cameron P Beaudreault; Joy S Park; Chiderah P Abani; James M Park; Derek T Le; Sasha Z Gonzalez; Youxin Guan; Bruce M Cohen; Donna L McPhie; Joseph T Coyle; Thomas A Lanz; Hualin S Xi; Changhong Yin; Weihua Huang; Hae-Young Kim; Sangmi Chung
Journal:  Nat Neurosci       Date:  2020-10-23       Impact factor: 24.884
  6 in total

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