Literature DB >> 28388426

lncRNA-Encoded Polypeptide SPAR(s) with mTORC1 to Regulate Skeletal Muscle Regeneration.

Shahragim Tajbakhsh1.   

Abstract

Although prematurely baptized as non-coding, some lncRNAs encode polypeptides with regulatory functions that are implicated in various biological processes. Matsumoto et al. (2017) recently report in Nature that LINC00961 generates SPAR polypeptide that acts via the lysosome to suppress amino-acid-mediated mTORC1 activity, thereby modulating skeletal muscle regenerative response following injury.
Copyright © 2017 Elsevier Inc. All rights reserved.

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Year:  2017        PMID： 28388426     DOI： 10.1016/j.stem.2017.03.016

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   24.633


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