Simin Mahinrad1, Annelotte E Vriend1, J Wouter Jukema2, Diana van Heemst1, Naveed Sattar3, Gerard Jan Blauw1, Peter W Macfarlane4, Elaine N Clark4, Anton J M de Craen1, Behnam Sabayan1,5,6. 1. Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands. 2. Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands. 3. BHF Glasgow Cardiovascular Research Center, University of Glasgow, Glasgow, UK. 4. Institute of Cardiovascular and Medical Science, University of Glasgow, Glasgow, UK. 5. Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands. 6. Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Abstract
BACKGROUND: Patients with advanced heart failure run a greater risk of dementia. Whether early cardiac structural changes also associate with cognitive decline is yet to be determined. OBJECTIVE: We tested whether left ventricular hypertrophy (LVH) derived from electrocardiogram associates with cognitive decline in older subjects at risk of cardiovascular disease. METHODS: We included 4,233 participants (mean age 75.2 years, 47.8% male) from PROSPER (PROspective Study of Pravastatin in the Elderly at Risk). LVH was assessed from baseline electrocardiograms by measuring the Sokolow-Lyon index. Higher levels of Sokolow-Lyon index indicate higher degrees of LVH. Cognitive domains involving selective attention, processing speed, and immediate and delayed memory were measured at baseline and repeated during a mean follow-up of 3.2 years. RESULTS: At baseline, LVH was not associated with worse cognitive function. During follow-up, participants with higher levels of LVH had a steeper decline in cognitive function including in selective attention (p = 0.009), processing speed (p = 0.010), immediate memory (p < 0.001), and delayed memory (p = 0.002). These associations were independent of cardiovascular risk factors, co-morbidities, and medications. CONCLUSION: LVH assessed by electrocardiogram associates with steeper decline in cognitive function of older subjects independent of cardiovascular risk factors and co-morbidities. This study provides further evidence on the link between subclinical cardiac structural changes and cognitive decline in older subjects.
BACKGROUND:Patients with advanced heart failure run a greater risk of dementia. Whether early cardiac structural changes also associate with cognitive decline is yet to be determined. OBJECTIVE: We tested whether left ventricular hypertrophy (LVH) derived from electrocardiogram associates with cognitive decline in older subjects at risk of cardiovascular disease. METHODS: We included 4,233 participants (mean age 75.2 years, 47.8% male) from PROSPER (PROspective Study of Pravastatin in the Elderly at Risk). LVH was assessed from baseline electrocardiograms by measuring the Sokolow-Lyon index. Higher levels of Sokolow-Lyon index indicate higher degrees of LVH. Cognitive domains involving selective attention, processing speed, and immediate and delayed memory were measured at baseline and repeated during a mean follow-up of 3.2 years. RESULTS: At baseline, LVH was not associated with worse cognitive function. During follow-up, participants with higher levels of LVH had a steeper decline in cognitive function including in selective attention (p = 0.009), processing speed (p = 0.010), immediate memory (p < 0.001), and delayed memory (p = 0.002). These associations were independent of cardiovascular risk factors, co-morbidities, and medications. CONCLUSION: LVH assessed by electrocardiogram associates with steeper decline in cognitive function of older subjects independent of cardiovascular risk factors and co-morbidities. This study provides further evidence on the link between subclinical cardiac structural changes and cognitive decline in older subjects.
Entities:
Keywords:
Cardiovascular disease; cognitive function; elderly; left ventricular hypertrophy
Authors: Kathleen M Hayden; Rebecca H Neiberg; Joni K Evans; José A Luchsinger; Owen Carmichael; Gareth R Dutton; Karen C Johnson; Steven E Kahn; Stephen R Rapp; Sevil Yasar; Mark A Espeland Journal: Dement Geriatr Cogn Disord Date: 2021-08-19 Impact factor: 3.346
Authors: Faye L Norby; Lin Y Chen; Elsayed Z Soliman; Rebecca F Gottesman; Thomas H Mosley; Alvaro Alonso Journal: Am Heart J Date: 2018-08-02 Impact factor: 4.749
Authors: Michelle H Zonneveld; Raymond Noordam; Jeroen van der Grond; Behnam Sabayan; Simon P Mooijaart; Peter W Mcfarlane; J Wouter Jukema; Stella Trompet Journal: J Clin Med Date: 2020-03-26 Impact factor: 4.241