Kathleen M Hayden1, Rebecca H Neiberg2, Joni K Evans2, José A Luchsinger3, Owen Carmichael4, Gareth R Dutton5, Karen C Johnson6, Steven E Kahn7, Stephen R Rapp1,8, Sevil Yasar9, Mark A Espeland2,10. 1. Department of Social Sciences and Health Policy, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA. 2. Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA. 3. Departments of Medicine and Epidemiology, Columbia University Irving Medical Center, New York, New York, USA. 4. Biomedical Imaging Center, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA. 5. Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA. 6. Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA. 7. Division of Metabolism, Endocrinology, and Nutrition, VA Puget Sound Health Care System and University of Washington, Seattle, Washington, USA. 8. Department of Psychiatry & Behavioral Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA. 9. Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA. 10. Sticht Division of Gerontology and Geriatric Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Abstract
INTRODUCTION: Weight loss and increased physical activity interventions are commonly recommended for individuals with type 2 diabetes (T2D) and overweight or obesity. We examined the impact of randomization to an intensive lifestyle intervention (ILI) on trajectories of cognitive function over 10 years in a cohort of participants in a randomized clinical trial who had T2D and overweight/obesity at baseline. METHODS: Participants aged 45-76 years were enrolled in 2001-2004 and were randomized to the ILI or a diabetes support and education (DSE) condition. Cognitive function was assessed in 3,938 participants at up to 4 time points 8-18 years after randomization. General linear mixed effects models examined cognitive trajectories over time. Subgroup analyses focused on sex, individuals with baseline body mass index >30, those carrying the APOE ε4 allele, and those with a baseline history of cardiovascular disease (CVD). RESULTS: Overall, there were no differences in the rate of cognitive decline by intervention arm. Subgroup analyses showed that participants who had a baseline history of CVD and were randomized to the ILI arm of the study performed significantly worse on the Stroop Color Word Test than those in the DSE arm. DISCUSSION/ CONCLUSIONS: The ILI did not result in preserved cognitive function or slower rates of cognitive decline in this cohort of individuals who had T2D and were overweight or obese at baseline.
INTRODUCTION: Weight loss and increased physical activity interventions are commonly recommended for individuals with type 2 diabetes (T2D) and overweight or obesity. We examined the impact of randomization to an intensive lifestyle intervention (ILI) on trajectories of cognitive function over 10 years in a cohort of participants in a randomized clinical trial who had T2D and overweight/obesity at baseline. METHODS: Participants aged 45-76 years were enrolled in 2001-2004 and were randomized to the ILI or a diabetes support and education (DSE) condition. Cognitive function was assessed in 3,938 participants at up to 4 time points 8-18 years after randomization. General linear mixed effects models examined cognitive trajectories over time. Subgroup analyses focused on sex, individuals with baseline body mass index >30, those carrying the APOE ε4 allele, and those with a baseline history of cardiovascular disease (CVD). RESULTS: Overall, there were no differences in the rate of cognitive decline by intervention arm. Subgroup analyses showed that participants who had a baseline history of CVD and were randomized to the ILI arm of the study performed significantly worse on the Stroop Color Word Test than those in the DSE arm. DISCUSSION/ CONCLUSIONS: The ILI did not result in preserved cognitive function or slower rates of cognitive decline in this cohort of individuals who had T2D and were overweight or obese at baseline.
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Authors: Annette L Fitzpatrick; Lewis H Kuller; Oscar L Lopez; Paula Diehr; Ellen S O'Meara; W T Longstreth; José A Luchsinger Journal: Arch Neurol Date: 2009-03
Authors: Kristen M Beavers; Iris Leng; Stephen R Rapp; Michael E Miller; Denise K Houston; Anthony P Marsh; Don G Hire; Laura D Baker; George A Bray; George L Blackburn; Andrea L Hergenroeder; John M Jakicic; Karen C Johnson; Mary T Korytkowski; Brent Van Dorsten; Stephen B Kritchevsky Journal: J Am Geriatr Soc Date: 2016-09-27 Impact factor: 5.562
Authors: Mark A Espeland; Owen Carmichael; Sevil Yasar; Christina Hugenschmidt; William Hazzard; Kathleen M Hayden; Stephen R Rapp; Rebecca Neiberg; Karen C Johnson; Siobhan Hoscheidt; Michelle M Mielke Journal: Alzheimers Dement Date: 2018-07-05 Impact factor: 21.566
Authors: Mark A Espeland; José A Luchsinger; Laura D Baker; Rebecca Neiberg; Steven E Kahn; Steven E Arnold; Rena R Wing; George L Blackburn; George Bray; Mary Evans; Helen P Hazuda; Robert W Jeffery; Valerie M Wilson; Jeanne M Clark; Mace Coday; Kathryn Demos-McDermott; John P Foreyt; Frank Greenway; James O Hill; Edward S Horton; John M Jakicic; Karen C Johnson; William C Knowler; Cora E Lewis; David M Nathan; Anne Peters; Xavier Pi-Sunyer; Henry Pownall; Thomas A Wadden; Stephen R Rapp Journal: Neurology Date: 2017-04-26 Impact factor: 9.910
Authors: Denise K Houston; Xiaoyan Leng; George A Bray; Andrea L Hergenroeder; James O Hill; John M Jakicic; Karen C Johnson; Rebecca H Neiberg; Anthony P Marsh; W Jack Rejeski; Stephen B Kritchevsky Journal: Obesity (Silver Spring) Date: 2014-11-29 Impact factor: 5.002
Authors: Kathleen M Hayden; Laura D Baker; George Bray; Raymond Carvajal; Kathryn Demos-McDermott; Andrea L Hergenroeder; James O Hill; Edward Horton; John M Jakicic; Karen C Johnson; Rebecca H Neiberg; Stephen R Rapp; Thomas A Wadden; Michael E Miller Journal: Alzheimers Dement (Amst) Date: 2017-10-09
Authors: Mark A Espeland; Joni K Evans; Owen Carmichael; Jose A Luchsinger; Santica M Marcovina; Rebecca Neiberg; Karen C Johnson; Steven E Kahn; Kathleen M Hayden Journal: Obesity (Silver Spring) Date: 2022-08-03 Impact factor: 9.298