Literature DB >> 2838582

Lack of effectiveness of forskolin or inositol as antidote in lithium toxicity. Short note.

Z Kaplan1, G Schreiber, R H Belmaker.   

Abstract

Forskolin, a direct adenylate cyclase stimulator, was suggested as a possible antidote to lithium toxicity, since lithium inhibits cyclic AMP accumulation. Inositol, a sugar isomer reduced in lithium treatment due to inhibition of inositol-1-phosphatase, was suggested as a possible antidote to lithium toxicity. Both were ineffective in a mouse model.

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Year:  1988        PMID： 2838582     DOI： 10.1007/BF01250239

Source DB:  PubMed          Journal:  J Neural Transm            Impact factor:   3.575


  9 in total

1.  Effects of lithium in vitro and ex vivo on components of the adenylate cyclase system in membranes from the cerebral cortex of the rat.

Authors:  M E Newman; R H Belmaker
Journal:  Neuropharmacology       Date:  1987 Feb-Mar       Impact factor: 5.250

2.  Lack of benefit from magnesium in lithium toxicity.

Authors:  J Zohar; D Spiro; A Novack; R P Ebstein; R H Belmaker
Journal:  Neuropsychobiology       Date:  1982       Impact factor: 2.328

3.  Systemic cholinergic agents induce seizures and brain damage in lithium-treated rats.

Authors:  M P Honchar; J W Olney; W R Sherman
Journal:  Science       Date:  1983-04-15       Impact factor: 47.728

4.  Difficulties in the clinical diagnosis of lithium toxicity.

Authors:  P S Appelbaum; R I Shader; H H Funkenstein; M A Hanson
Journal:  Am J Psychiatry       Date:  1979-09       Impact factor: 18.112

5.  Effects of forskolin and cyclic nucleotides in animal models predictive of antidepressant activity: interactions with rolipram.

Authors:  H Wachtel; P A Löschmann
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530

6.  Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands.

Authors:  M J Berridge; C P Downes; M R Hanley
Journal:  Biochem J       Date:  1982-09-15       Impact factor: 3.857

7.  Lithium-induced reduction in intracellular inositol supply in cholinergically stimulated parotid gland.

Authors:  C P Downes; M A Stone
Journal:  Biochem J       Date:  1986-02-15       Impact factor: 3.857

8.  Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells.

Authors:  K B Seamon; W Padgett; J W Daly
Journal:  Proc Natl Acad Sci U S A       Date:  1981-06       Impact factor: 11.205

9.  Receptors, adenylate cyclase, depression, and lithium.

Authors:  R H Belmaker
Journal:  Biol Psychiatry       Date:  1981-04       Impact factor: 13.382
  9 in total
  2 in total

1.  The effect of acute and chronic lithium on forskolin-induced reduction of rat activity.

Authors:  Y Bersudsky; Y Patishi; J Bitsch Jensen; A Mørk; O Kofman; R H Belmaker
Journal:  J Neural Transm (Vienna)       Date:  1997       Impact factor: 3.575

2.  A preliminary study of possible psychoactive effects of intravenous forskolin in depressed and schizophrenic patients. Short communication.

Authors:  Y Bersudsky; M Kotler; M Shifrin; R H Belmaker
Journal:  J Neural Transm (Vienna)       Date:  1996       Impact factor: 3.575
  2 in total

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