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Literature DB >> 6301005

Systemic cholinergic agents induce seizures and brain damage in lithium-treated rats.

Abstract

Administration of pilocarpine or physostigmine to rats treated with lithium chloride produced sustained limbic seizures, widespread brain damage, and increased concentrations of D-myo-inositol-1-phosphate (a metabolite of the phosphoinositides, lipids involved in membrane receptor function) in the brain. The syndrome was preventable with atropine. The physostigmine doses and concentrations of blood lithium that caused the syndrome are similar to those considered appropriate for psychiatric chemotherapy.

Entities: Chemical Disease Species

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Year: 1983 PMID： 6301005 DOI： 10.1126/science.6301005

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

54 in total

1. Altered residual ATP content in rat brain cortex subcellular fractions following status epilepticus induced by lithium and pilocarpine.

Authors: N Y Walton; A K Nagy; D M Treiman
Journal: J Mol Neurosci Date: 1998-12 Impact factor: 3.444

2. Geomagnetic activity and enhanced mortality in rats with acute (epileptic) limbic lability.

Authors: Y R Bureau; M A Persinger
Journal: Int J Biometeorol Date: 1992-10 Impact factor: 3.787

3. Rapamycin attenuates aggressive behavior in a rat model of pilocarpine-induced epilepsy.

Authors: X Huang; J McMahon; Y Huang
Journal: Neuroscience Date: 2012-04-20 Impact factor: 3.590

Review 4. Lessons from the laboratory: the pathophysiology, and consequences of status epilepticus.

Authors: Karthik Rajasekaran; Santina A Zanelli; Howard P Goodkin
Journal: Semin Pediatr Neurol Date: 2010-09 Impact factor: 1.636

5. Factors affecting outcomes of pilocarpine treatment in a mouse model of temporal lobe epilepsy.

Authors: Paul S Buckmaster; Megan M Haney
Journal: Epilepsy Res Date: 2012-06-19 Impact factor: 3.045

6. Cerebral perfusion alterations during the acute phase of experimental generalized status epilepticus: prediction of survival by using perfusion-weighted MR imaging and histopathology.

Authors: T Engelhorn; A Doerfler; J Weise; M Baehr; M Forsting; A Hufnagel
Journal: AJNR Am J Neuroradiol Date: 2005 Jun-Jul Impact factor: 3.825

Systemic cholinergic agents induce seizures and brain damage in lithium-treated rats.

1. Altered residual ATP content in rat brain cortex subcellular fractions following status epilepticus induced by lithium and pilocarpine.

2. Geomagnetic activity and enhanced mortality in rats with acute (epileptic) limbic lability.

3. Rapamycin attenuates aggressive behavior in a rat model of pilocarpine-induced epilepsy.

Review 4. Lessons from the laboratory: the pathophysiology, and consequences of status epilepticus.

5. Factors affecting outcomes of pilocarpine treatment in a mouse model of temporal lobe epilepsy.

6. Cerebral perfusion alterations during the acute phase of experimental generalized status epilepticus: prediction of survival by using perfusion-weighted MR imaging and histopathology.

7. Circadian variation in rat brain AP-1 DNA binding activity after cholinergic stimulation: modulation by lithium.

8. Subunit-specific trafficking of GABA(A) receptors during status epilepticus.

9. Restoration of brain myo-inositol levels in rats increases latency to lithium-pilocarpine seizures.

10. The CREB/CRE transcriptional pathway: protection against oxidative stress-mediated neuronal cell death.