Literature DB >> 28385196

Enabling Task-Specific Volitional Motor Functions via Spinal Cord Neuromodulation in a Human With Paraplegia.

Peter J Grahn1, Igor A Lavrov1, Dimitry G Sayenko2, Meegan G Van Straaten3, Megan L Gill3, Jeffrey A Strommen3, Jonathan S Calvert4, Dina I Drubach1, Lisa A Beck3, Margaux B Linde3, Andrew R Thoreson3, Cesar Lopez3, Aldo A Mendez1, Parag N Gad2, Yury P Gerasimenko5, V Reggie Edgerton2, Kristin D Zhao6, Kendall H Lee7.   

Abstract

We report a case of chronic traumatic paraplegia in which epidural electrical stimulation (EES) of the lumbosacral spinal cord enabled (1) volitional control of task-specific muscle activity, (2) volitional control of rhythmic muscle activity to produce steplike movements while side-lying, (3) independent standing, and (4) while in a vertical position with body weight partially supported, voluntary control of steplike movements and rhythmic muscle activity. This is the first time that the application of EES enabled all of these tasks in the same patient within the first 2 weeks (8 stimulation sessions total) of EES therapy.
Copyright © 2017 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

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Year:  2017        PMID: 28385196     DOI: 10.1016/j.mayocp.2017.02.014

Source DB:  PubMed          Journal:  Mayo Clin Proc        ISSN: 0025-6196            Impact factor:   7.616


  65 in total

1.  Epidural Spinal Cord Stimulation Training and Sustained Recovery of Cardiovascular Function in Individuals With Chronic Cervical Spinal Cord Injury.

Authors:  Susan J Harkema; Bonnie Legg Ditterline; Siqi Wang; Sevda Aslan; Claudia A Angeli; Alexander Ovechkin; Glenn A Hirsch
Journal:  JAMA Neurol       Date:  2018-12-01       Impact factor: 18.302

2.  Anatomical Plasticity of Rostrally Terminating Axons as a Possible Bridging Substrate across a Spinal Injury.

Authors:  Adele E Doperalski; Lynnette R Montgomery; Sarah E Mondello; Dena R Howland
Journal:  J Neurotrauma       Date:  2019-12-23       Impact factor: 5.269

3.  Complications of epidural spinal stimulation: lessons from the past and alternatives for the future.

Authors:  Giuliano Taccola; Sean Barber; Phillip J Horner; Humberto A Cerrel Bazo; Dimitry Sayenko
Journal:  Spinal Cord       Date:  2020-06-23       Impact factor: 2.772

Review 4.  Toward Functional Restoration of the Central Nervous System: A Review of Translational Neuroscience Principles.

Authors:  Max O Krucoff; Jonathan P Miller; Tarun Saxena; Ravi Bellamkonda; Shervin Rahimpour; Stephen C Harward; Shivanand P Lad; Dennis A Turner
Journal:  Neurosurgery       Date:  2019-01-01       Impact factor: 4.654

5.  Transcutaneous Electrical Spinal Stimulation Promotes Long-Term Recovery of Upper Extremity Function in Chronic Tetraplegia.

Authors:  Fatma Inanici; Soshi Samejima; Parag Gad; V Reggie Edgerton; Christoph P Hofstetter; Chet T Moritz
Journal:  IEEE Trans Neural Syst Rehabil Eng       Date:  2018-06       Impact factor: 3.802

Review 6.  Clinical Trials in Traumatic Spinal Cord Injury.

Authors:  Jayne Donovan; Steven Kirshblum
Journal:  Neurotherapeutics       Date:  2018-07       Impact factor: 7.620

7.  Trunk Stability Enabled by Noninvasive Spinal Electrical Stimulation after Spinal Cord Injury.

Authors:  Mrinal Rath; Albert H Vette; Shyamsundar Ramasubramaniam; Kun Li; Joel Burdick; Victor R Edgerton; Yury P Gerasimenko; Dimitry G Sayenko
Journal:  J Neurotrauma       Date:  2018-07-05       Impact factor: 5.269

8.  Enabling respiratory control after severe chronic tetraplegia: an exploratory case study.

Authors:  Parag Gad; Evgeniy Kreydin; Hui Zhong; V Reggie Edgerton
Journal:  J Neurophysiol       Date:  2020-08-05       Impact factor: 2.714

Review 9.  And yet it moves: Recovery of volitional control after spinal cord injury.

Authors:  G Taccola; D Sayenko; P Gad; Y Gerasimenko; V R Edgerton
Journal:  Prog Neurobiol       Date:  2017-11-02       Impact factor: 11.685

10.  Non-Invasive Activation of Cervical Spinal Networks after Severe Paralysis.

Authors:  Parag Gad; Sujin Lee; Nicholas Terrafranca; Hui Zhong; Amanda Turner; Yury Gerasimenko; V Reggie Edgerton
Journal:  J Neurotrauma       Date:  2018-09-15       Impact factor: 5.269

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