A Malhotra1,2,3, M C Fahey2,3, M Davies-Tuck2, F Wong1,2,3, E Carse1, G Whiteley4, M Ditchfield3,4,5. 1. Monash Newborn, Monash Children's Hospital, Melbourne, Victoria, Australia. 2. The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Victoria, Australia. 3. Department of Paediatrics, Monash University, Melbourne, Victoria, Australia. 4. Diagnostic Imaging, Monash Health, Melbourne, Victoria, Australia. 5. Department of Diagnostic Imaging, Monash University, Melbourne, Victoria, Australia.
Abstract
OBJECTIVE: To compare information obtained from preterm magnetic resonance imaging (MRI; 31-34 weeks) brain scan to that done at term equivalent age. STUDY DESIGN: Prospective observational study of premature infants with evidence or suspicion of parenchymal brain injury on cranial ultrasound. Brain injury on two scans scored using a scoring system and analyzed. RESULTS: Fourteen infants with a median (range) gestation at birth of 28 (25-29) weeks and birth weight of 1254 (680-1557) grams were studied. There was a strong correlation between the brain injury scores for the two scans (Spearman ρ=0.87, P=0.001) with excellent agreement between two radiologists (interclass correlation coefficient 0.9-0.94). There was also a high level of agreement between the preterm and term MRI two scores (Intraclass correlation coefficient, 0.79 (0.53-0.94)). CONCLUSIONS: Preterm MRI is a feasible option for the assessment of preterm brain injury and analysis of data obtained from scan at preterm age is comparable to that obtained at term equivalent age.
OBJECTIVE: To compare information obtained from preterm magnetic resonance imaging (MRI; 31-34 weeks) brain scan to that done at term equivalent age. STUDY DESIGN: Prospective observational study of premature infants with evidence or suspicion of parenchymal brain injury on cranial ultrasound. Brain injury on two scans scored using a scoring system and analyzed. RESULTS: Fourteen infants with a median (range) gestation at birth of 28 (25-29) weeks and birth weight of 1254 (680-1557) grams were studied. There was a strong correlation between the brain injury scores for the two scans (Spearman ρ=0.87, P=0.001) with excellent agreement between two radiologists (interclass correlation coefficient 0.9-0.94). There was also a high level of agreement between the preterm and term MRI two scores (Intraclass correlation coefficient, 0.79 (0.53-0.94)). CONCLUSIONS: Preterm MRI is a feasible option for the assessment of preterm brain injury and analysis of data obtained from scan at preterm age is comparable to that obtained at term equivalent age.
Authors: Hannah C Glass; Sonia L Bonifacio; Vann Chau; David Glidden; Kenneth Poskitt; A James Barkovich; Donna M Ferriero; Steven P Miller Journal: Pediatrics Date: 2008-08 Impact factor: 7.124
Authors: Marnie N Robinson; Lyndal J Peake; Michael R Ditchfield; Susan M Reid; Anna Lanigan; Dinah S Reddihough Journal: Dev Med Child Neurol Date: 2008-10-17 Impact factor: 5.449