Literature DB >> 2838308

Inhibition by cAMP of the phosphoinositide response to alpha 1-adrenoceptor stimulation in rat kidney.

C B Neylon1, R J Summers.   

Abstract

The effect of increasing intracellular levels of cAMP has been investigated on the PI response to stimulation of alpha 1-adrenoceptors in rat kidney. Stimulation of adenylate cyclase with forskolin or incubation with dibutyryl cAMP (dcAMP) inhibited noradrenaline (NA)-stimulated [3H]inositol phosphate (IP) accumulation. Forskolin did not alter the EC50 to NA. No effect on NA-stimulated [3H]IP accumulation was seen with dibutyryl cGMP (dcGMP). The results suggest that hormones which produce alterations in cAMP levels influence alpha 1-adrenoceptor-mediated responses.

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Year:  1988        PMID： 2838308     DOI： 10.1016/0014-2999(88)90124-0

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  9 in total

1.  Modulation of muscarinic receptor-mediated adenylate cyclase and phospholipase C responses in rat retina.

Authors:  M Hadjiconstantinou; S E Moroi-Fetters; S Z Qu; N H Neff
Journal:  Cell Mol Neurobiol       Date:  1991-10       Impact factor: 5.046

2.  Comparison of alpha 1A- and alpha 1B-adrenoceptor coupling to inositol phosphate formation in rat kidney.

Authors:  R Büscher; W Erdbrügger; T Philipp; O E Brodde; M C Michel
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1994-12       Impact factor: 3.000

3.  Modulation of fluoroaluminate-induced inositol phosphate formation by increases in tissue cyclic AMP content in bovine tracheal smooth muscle.

Authors:  I P Hall; J Donaldson; S J Hill
Journal:  Br J Pharmacol       Date:  1990-07       Impact factor: 8.739

4.  Cyclic adenosine monophosphate and diacylglycerol. Mutually inhibitory second messengers in cultured rat inner medullary collecting duct cells.

Authors:  I Teitelbaum
Journal:  J Clin Invest       Date:  1990-07       Impact factor: 14.808

5.  Inhibition of histamine-stimulated inositol phospholipid hydrolysis by agents which increase cyclic AMP levels in bovine tracheal smooth muscle.

Authors:  I P Hall; J Donaldson; S J Hill
Journal:  Br J Pharmacol       Date:  1989-06       Impact factor: 8.739

6.  Renal tubular dopamine outward transfer during Na(+)-H+ exchange activation by alpha 1- and alpha 2-adrenoceptor agonists.

Authors:  P Soares-da-Silva
Journal:  Br J Pharmacol       Date:  1993-06       Impact factor: 8.739

7.  Potentiation of alpha-adrenoceptor-mediated responses following chronic beta-adrenoceptor stimulation in the rat heart.

Authors:  M C Butterfield; R Chess-Williams
Journal:  Br J Pharmacol       Date:  1993-03       Impact factor: 8.739

8.  Acetylcholine- and caffeine-evoked repetitive transient Ca(2+)-activated K+ and C1- currents in mouse submandibular cells.

Authors:  P M Smith; D V Gallacher
Journal:  J Physiol       Date:  1992-04       Impact factor: 5.182

9.  Protein kinase regulation of muscarinic receptor signalling in colonic smooth muscle.

Authors:  L Zhang; I L Buxton
Journal:  Br J Pharmacol       Date:  1993-03       Impact factor: 8.739
  9 in total

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