Literature DB >> 1660349

Modulation of muscarinic receptor-mediated adenylate cyclase and phospholipase C responses in rat retina.

M Hadjiconstantinou1, S E Moroi-Fetters, S Z Qu, N H Neff.   

Abstract

1. Agonist activation of rat retina muscarinic receptors results in suppression of cyclic AMP (cAMP) generation and enhanced phosphoinositide hydrolysis. 2. Pharmacological manipulations that elevate cAMP or stable analogues of cAMP attenuate the acetylcholine (ACh)-induced enhancement of phosphoinositide hydrolysis. We postulate that cross-talk between adenylate cyclase and phospholipase C signal transducing systems probably exists in rat retina, as has been described for other systems. 3. Intraocular administration of pertussis toxin attenuated the response of both adenylate cyclase and phospholipase C to muscarinic stimulation, suggesting that some retinal muscarinic receptors are apparently coupled to their effector systems via pertussis toxin sensitive G proteins.

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Year:  1991        PMID： 1660349     DOI： 10.1007/bf00734809

Source DB:  PubMed          Journal:  Cell Mol Neurobiol        ISSN： 0272-4340            Impact factor:   5.046


  39 in total

1.  Phorbol esters attenuate glutamate-stimulated inositol phospholipid hydrolysis in neuronal cultures.

Authors:  P L Canonico; A Favit; M V Catania; F Nicoletti
Journal:  J Neurochem       Date:  1988-10       Impact factor: 5.372

2.  Effect of cyclic AMP-dependent hormones and Ca2+-mobilizing hormones on the Ca2+ influx and polyphosphoinositide metabolism in isolated rat hepatocytes.

Authors:  J Poggioli; J P Mauger; M Claret
Journal:  Biochem J       Date:  1986-05-01       Impact factor: 3.857

3.  Modulation of adenylate cyclase of human platelets by phorbol ester. Impairment of the hormone-sensitive inhibitory pathway.

Authors:  K H Jakobs; S Bauer; Y Watanabe
Journal:  Eur J Biochem       Date:  1985-09-02

4.  Phorbol ester-mediated inhibition of vasopressin and beta-adrenergic responses in a vascular smooth muscle cell line.

Authors:  N Aiyar; P Nambi; M Whitman; F L Stassen; S T Crooke
Journal:  Mol Pharmacol       Date:  1987-02       Impact factor: 4.436

5.  Muscarinic receptor-mediated phosphoinositide hydrolysis in the rat retina.

Authors:  S E Moroi-Fetters; N H Neff; M Hadjiconstantinou
Journal:  J Pharmacol Exp Ther       Date:  1988-08       Impact factor: 4.030

6.  Alterations of glial tumor cell Ca2+ metabolism and Ca2+-dependent cAMP accumulation by phorbol myristate acetate.

Authors:  M A Brostrom; C O Brostrom; L A Brotman; C Lee; D J Wolff; H M Geller
Journal:  J Biol Chem       Date:  1982-06-25       Impact factor: 5.157

7.  In rat hippocampus, somatostatin 14 and muscarinic receptor ligands modulate an adenylate cyclase belonging to a common domain of the receptor.

Authors:  C Eva; E Costa
Journal:  J Pharmacol Exp Ther       Date:  1987-09       Impact factor: 4.030

Review 8.  Forskolin: a specific stimulator of adenylyl cyclase or a diterpene with multiple sites of action?

Authors:  A Laurenza; E M Sutkowski; K B Seamon
Journal:  Trends Pharmacol Sci       Date:  1989-11       Impact factor: 14.819

9.  Pharmacological characterization of muscarinic receptors mediating inhibition of adenylate cyclase activity in the rat retina.

Authors:  Z X Qu; R Fertel; N H Neff; M Hadjiconstantinou
Journal:  J Pharmacol Exp Ther       Date:  1988-09       Impact factor: 4.030

10.  Psoralens increase the concentration of cyclic AMP in human cells in vitro.

Authors:  C R Albrightson; R H Fertel; B V Brown; R Stephens
Journal:  J Invest Dermatol       Date:  1985-09       Impact factor: 8.551
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