Electronic cigarettes: age-specific generation-resolved pulmonary doses.

Particle size-number distributions of aerosol from e-cigarettes (0 and 14 mg mL-1 nicotine) were compared with conventional cigarettes. Results were used to provide age-specific (9-21 years) dosimetry estimates applying the MMPD model. After a 2-s puff, total number doses (D Tot ) were highest for 9 years of age (6.01 × 1010-1.31 × 1011 particles) and lowest for 18 years of age (4.69 × 1010-1.06 × 1011 particles). Such doses represented about 19-45 and 25-100% of the relevant daily doses of not smoking individuals, respectively, in tracheobronchial (TB) and alveolar (A) regions. D Tot for the e-cigarettes were about double that for conventional cigarette. Deposition densities and daily volume of e-cigarette liquid deposited per unit surface area were maximum at lobar bronchi, highest for 9 years and lowest for 21 years age.