Literature DB >> 28380338

Understanding CARD Tricks in Apoptosomes.

Li Wang1, Qi Qiao1, Hao Wu2.   

Abstract

While earlier studies of Apaf-1 holo-apoptosome architecture revealed the spectacular heptameric wheel-like structure formed by Apaf-1, the central CARD disk responsible for caspase-9 recruitment remained incompletely resolved. In a recent issue of Structure, Su et al. (2017) describe a crystal structure of the complex between Apaf-1 CARD and caspase-9 CARD. Together with two recent cryo-EM structures, this work brings us closer to a full view of the holo-apoptosome.
Copyright © 2017 Elsevier Ltd. All rights reserved.

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Year:  2017        PMID： 28380338      PMCID： PMC5530255          DOI： 10.1016/j.str.2017.03.013

Source DB:  PubMed          Journal:  Structure        ISSN： 0969-2126            Impact factor:   5.006


  11 in total

1.  Molecular determinants of caspase-9 activation by the Apaf-1 apoptosome.

Authors:  Qi Hu; Di Wu; Wen Chen; Zhen Yan; Chuangye Yan; Tianxi He; Qionglin Liang; Yigong Shi
Journal:  Proc Natl Acad Sci U S A       Date:  2014-10-13       Impact factor: 11.205

2.  Structural Insights into DD-Fold Assembly and Caspase-9 Activation by the Apaf-1 Apoptosome.

Authors:  Tsung-Wei Su; Chao-Yu Yang; Wen-Pin Kao; Bai-Jiun Kuo; Shan-Meng Lin; Jung-Yaw Lin; Yu-Chih Lo; Su-Chang Lin
Journal:  Structure       Date:  2017-01-19       Impact factor: 5.006

Review 3.  Helical assembly in the death domain (DD) superfamily.

Authors:  Ryan Ferrao; Hao Wu
Journal:  Curr Opin Struct Biol       Date:  2012-03-17       Impact factor: 6.809

Review 4.  Structural biology of innate immunity.

Authors:  Qian Yin; Tian-Min Fu; Jixi Li; Hao Wu
Journal:  Annu Rev Immunol       Date:  2015-01-22       Impact factor: 28.527

Review 5.  Apoptosome structure, assembly, and procaspase activation.

Authors:  Shujun Yuan; Christopher W Akey
Journal:  Structure       Date:  2013-04-02       Impact factor: 5.006

6.  Structure of the apoptosome: mechanistic insights into activation of an initiator caspase from Drosophila.

Authors:  Yuxuan Pang; Xiao-chen Bai; Chuangye Yan; Qi Hao; Zheqin Chen; Jia-Wei Wang; Sjors H W Scheres; Yigong Shi
Journal:  Genes Dev       Date:  2015-02-01       Impact factor: 11.361

7.  Mechanistic insights into caspase-9 activation by the structure of the apoptosome holoenzyme.

Authors:  Yini Li; Mengying Zhou; Qi Hu; Xiao-Chen Bai; Weiyun Huang; Sjors H W Scheres; Yigong Shi
Journal:  Proc Natl Acad Sci U S A       Date:  2017-01-31       Impact factor: 11.205

8.  Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism.

Authors:  Alvin Lu; Yang Li; Florian I Schmidt; Qian Yin; Shuobing Chen; Tian-Min Fu; Alexander B Tong; Hidde L Ploegh; Youdong Mao; Hao Wu
Journal:  Nat Struct Mol Biol       Date:  2016-04-04       Impact factor: 15.369

9.  Plasticity in PYD assembly revealed by cryo-EM structure of the PYD filament of AIM2.

Authors:  Alvin Lu; Yang Li; Qian Yin; Jianbin Ruan; Xiong Yu; Edward Egelman; Hao Wu
Journal:  Cell Discov       Date:  2015-06-23       Impact factor: 10.849

10.  A near atomic structure of the active human apoptosome.

Authors:  Tat Cheung Cheng; Chuan Hong; Ildikó V Akey; Shujun Yuan; Christopher W Akey
Journal:  Elife       Date:  2016-10-04       Impact factor: 8.140
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  1 in total

1.  Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1.

Authors:  Yang Li; Tian-Min Fu; Alvin Lu; Kristen Witt; Jianbin Ruan; Chen Shen; Hao Wu
Journal:  Proc Natl Acad Sci U S A       Date:  2018-10-02       Impact factor: 11.205
  1 in total

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