BACKGROUND: Enterovirus D68 (EV-D68) caused a widespread outbreak of respiratory illness in the United States in 2014, predominantly affecting children. We describe EV-D68 rates, spectrum of illness, and risk factors from prospective, population-based acute respiratory illness (ARI) surveillance at a large US pediatric hospital. METHODS: Children <13 years of age with ARI and residence in Hamilton County, Ohio were enrolled from the inpatient and emergency department (ED) settings at a children's hospital in Cincinnati, Ohio, from 1 July to 31 October 2014. For each participant, we interviewed parents, reviewed medical records, and tested nasal and throat swabs for EV-D68 using real-time reverse- transcription polymerase chain reaction assay. RESULTS: EV-D68 infection was detected in 51 of 207 (25%) inpatients and 58 of 505 (11%) ED patients. Rates of EV-D68 hospitalization and ED visit were 1.3 (95% confidence interval [CI], 1.0-1.6) and 8.4 per 1000 children <13 years of age, respectively. Preexisting asthma was associated with EV-D68 infection (adjusted odds ratio, 3.2; 95% CI, 2.0-5.1). Compared with other ARI, children with EV-D68 were more likely to be admitted from the ED (P ≤ .001), receive supplemental oxygen (P = .001), and require intensive care unit admission (P = .04); however, mechanical ventilation was uncommon (2/51 inpatients; P = .64), and no deaths occurred. CONCLUSIONS: During the 2014 EV-D68 epidemic, high rates of pediatric hospitalizations and ED visits were observed. Children with asthma were at increased risk for medically attended EV-D68 illness. Preparedness planning for a high-activity EV-D68 season in the United States should take into account increased healthcare utilization, particularly among children with asthma, during the late summer and early fall. Published by Oxford University Press for the Infectious Diseases Society of America 2017. This work is written by (a) US Government employee(s) and is in the public domain in the US.
BACKGROUND: Enterovirus D68 (EV-D68) caused a widespread outbreak of respiratory illness in the United States in 2014, predominantly affecting children. We describe EV-D68 rates, spectrum of illness, and risk factors from prospective, population-based acute respiratory illness (ARI) surveillance at a large US pediatric hospital. METHODS: Children <13 years of age with ARI and residence in Hamilton County, Ohio were enrolled from the inpatient and emergency department (ED) settings at a children's hospital in Cincinnati, Ohio, from 1 July to 31 October 2014. For each participant, we interviewed parents, reviewed medical records, and tested nasal and throat swabs for EV-D68 using real-time reverse- transcription polymerase chain reaction assay. RESULTS: EV-D68 infection was detected in 51 of 207 (25%) inpatients and 58 of 505 (11%) ED patients. Rates of EV-D68 hospitalization and ED visit were 1.3 (95% confidence interval [CI], 1.0-1.6) and 8.4 per 1000 children <13 years of age, respectively. Preexisting asthma was associated with EV-D68 infection (adjusted odds ratio, 3.2; 95% CI, 2.0-5.1). Compared with other ARI, children with EV-D68 were more likely to be admitted from the ED (P ≤ .001), receive supplemental oxygen (P = .001), and require intensive care unit admission (P = .04); however, mechanical ventilation was uncommon (2/51 inpatients; P = .64), and no deaths occurred. CONCLUSIONS: During the 2014 EV-D68 epidemic, high rates of pediatric hospitalizations and ED visits were observed. Children with asthma were at increased risk for medically attended EV-D68 illness. Preparedness planning for a high-activity EV-D68 season in the United States should take into account increased healthcare utilization, particularly among children with asthma, during the late summer and early fall. Published by Oxford University Press for the Infectious Diseases Society of America 2017. This work is written by (a) US Government employee(s) and is in the public domain in the US.
Authors: Paul A Harris; Robert Taylor; Robert Thielke; Jonathon Payne; Nathaniel Gonzalez; Jose G Conde Journal: J Biomed Inform Date: 2008-09-30 Impact factor: 6.317
Authors: Katherine A Poehling; Kathryn M Edwards; Marie R Griffin; Peter G Szilagyi; Mary A Staat; Marika K Iwane; Beverly M Snively; Cynthia K Suerken; Caroline B Hall; Geoffrey A Weinberg; Sandra S Chaves; Yuwei Zhu; Monica M McNeal; Carolyn B Bridges Journal: Pediatrics Date: 2013-01-06 Impact factor: 7.124
Authors: Seema Jain; Derek J Williams; Sandra R Arnold; Krow Ampofo; Anna M Bramley; Carrie Reed; Chris Stockmann; Evan J Anderson; Carlos G Grijalva; Wesley H Self; Yuwei Zhu; Anami Patel; Weston Hymas; James D Chappell; Robert A Kaufman; J Herman Kan; David Dansie; Noel Lenny; David R Hillyard; Lia M Haynes; Min Levine; Stephen Lindstrom; Jonas M Winchell; Jacqueline M Katz; Dean Erdman; Eileen Schneider; Lauri A Hicks; Richard G Wunderink; Kathryn M Edwards; Andrew T Pavia; Jonathan A McCullers; Lyn Finelli Journal: N Engl J Med Date: 2015-02-26 Impact factor: 91.245
Authors: Astride Jules; Carlos G Grijalva; Yuwei Zhu; H Keipp Talbot; John V Williams; Katherine A Poehling; Sandra S Chaves; Kathryn M Edwards; William Schaffner; David K Shay; Marie R Griffin Journal: Pediatrics Date: 2014-12-08 Impact factor: 7.124
Authors: Kathryn M Edwards; Yuwei Zhu; Marie R Griffin; Geoffrey A Weinberg; Caroline B Hall; Peter G Szilagyi; Mary A Staat; Marika Iwane; Mila M Prill; John V Williams Journal: N Engl J Med Date: 2013-02-14 Impact factor: 91.245
Authors: M Steven Oberste; Kaija Maher; David Schnurr; Mary R Flemister; Judith C Lovchik; Heather Peters; Wendy Sessions; Carol Kirk; Nando Chatterjee; Susan Fuller; J Michael Hanauer; Mark A Pallansch Journal: J Gen Virol Date: 2004-09 Impact factor: 3.891
Authors: Wesley H Self; Carlos G Grijalva; Yuwei Zhu; H Keipp Talbot; Astride Jules; Kyle E Widmer; Kathryn M Edwards; John V Williams; David K Shay; Marie R Griffin Journal: Emerg Infect Dis Date: 2012-05 Impact factor: 6.883
Authors: Jennifer L McKimm-Breschkin; Shibo Jiang; David S Hui; John H Beigel; Elena A Govorkova; Nelson Lee Journal: Antiviral Res Date: 2017-11-21 Impact factor: 5.970
Authors: Timothy J Savage; Jane Kuypers; Helen Y Chu; Miranda C Bradford; Anne Marie Buccat; Xuan Qin; Eileen J Klein; Keith R Jerome; Janet A Englund; Alpana Waghmare Journal: Influenza Other Respir Viruses Date: 2018-03-23 Impact factor: 4.380
Authors: Melisa M Shah; Ariana Perez; Joana Y Lively; Vasanthi Avadhanula; Julie A Boom; James Chappell; Janet A Englund; Wende Fregoe; Natasha B Halasa; Christopher J Harrison; Robert W Hickey; Eileen J Klein; Monica M McNeal; Marian G Michaels; Mary E Moffatt; Catherine Otten; Leila C Sahni; Elizabeth Schlaudecker; Jennifer E Schuster; Rangaraj Selvarangan; Mary A Staat; Laura S Stewart; Geoffrey A Weinberg; John V Williams; Terry Fan Fei Ng; Janell A Routh; Susan I Gerber; Meredith L McMorrow; Brian Rha; Claire M Midgley Journal: MMWR Morb Mortal Wkly Rep Date: 2021-11-26 Impact factor: 17.586
Authors: Kevin C Ma; Amber Winn; Heidi L Moline; Heather M Scobie; Claire M Midgley; Hannah L Kirking; Jennifer Adjemian; Kathleen P Hartnett; Dylan Johns; Jefferson M Jones; Adriana Lopez; Xiaoyan Lu; Ariana Perez; Cria G Perrine; Andzelika E Rzucidlo; Meredith L McMorrow; Benjamin J Silk; Zachary Stein; Everardo Vega; Aron J Hall Journal: MMWR Morb Mortal Wkly Rep Date: 2022-10-07 Impact factor: 35.301