Astride Jules1, Carlos G Grijalva1, Yuwei Zhu2, H Keipp Talbot3, John V Williams4, Katherine A Poehling5, Sandra S Chaves6, Kathryn M Edwards7, William Schaffner1, David K Shay6, Marie R Griffin8. 1. Departments of Health Policy. 2. Biostatistics. 3. Medicine. 4. Pediatrics, and Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee; 5. Departments of Pediatrics and Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, North Carolina; and. 6. Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia. 7. Pediatrics, and. 8. Departments of Health Policy, Medicine, marie.griffin@vanderbilt.edu.
Abstract
BACKGROUND AND OBJECTIVES: In the United States, recommendations for annual influenza vaccination gradually expanded from 2004 to 2008, to include all children aged ≥6 months. The effects of these policies on vaccine uptake and influenza-associated health care encounters are unclear. The objectives of the study were to examine the annual incidence of influenza-related health care encounters and vaccine uptake among children age 6 to 59 months from 2000-2001 through 2010-2011 in Davidson County, TN. METHODS: We estimated the proportion of laboratory-confirmed influenza-related hospitalizations and emergency department (ED) visits by enrolling and testing children with acute respiratory illness or fever. We estimated influenza-related health care encounters by multiplying these proportions by the number of acute respiratory illness/fever hospitalizations and ED visits for county residents. We assessed temporal trends in vaccination coverage, and influenza-associated hospitalizations and ED visit rates. RESULTS: The proportion of fully vaccinated children increased from 6% in 2000-2001 to 38% in 2010-2011 (P < .05). Influenza-related hospitalizations ranged from 1.9 to 16.0 per 10 000 children (median 4.5) per year. Influenza-related ED visits ranged from 89 to 620 per 10 000 children (median 143) per year. Significant decreases in hospitalizations (P < .05) and increases in ED visits (P < .05) over time were not clearly related to vaccination trends. Influenza-related encounters were greater when influenza A(H3N2) circulated than during other years with median rates of 8.2 vs 3.2 hospitalizations and 307 vs 143 ED visits per 10 000 children, respectively. CONCLUSIONS: Influenza vaccination increased over time; however, the proportion of fully vaccinated children remained <50%. Influenza was associated with a substantial illness burden particularly when influenza A(H3N2) predominated.
BACKGROUND AND OBJECTIVES: In the United States, recommendations for annual influenza vaccination gradually expanded from 2004 to 2008, to include all children aged ≥6 months. The effects of these policies on vaccine uptake and influenza-associated health care encounters are unclear. The objectives of the study were to examine the annual incidence of influenza-related health care encounters and vaccine uptake among children age 6 to 59 months from 2000-2001 through 2010-2011 in Davidson County, TN. METHODS: We estimated the proportion of laboratory-confirmed influenza-related hospitalizations and emergency department (ED) visits by enrolling and testing children with acute respiratory illness or fever. We estimated influenza-related health care encounters by multiplying these proportions by the number of acute respiratory illness/fever hospitalizations and ED visits for county residents. We assessed temporal trends in vaccination coverage, and influenza-associated hospitalizations and ED visit rates. RESULTS: The proportion of fully vaccinated children increased from 6% in 2000-2001 to 38% in 2010-2011 (P < .05). Influenza-related hospitalizations ranged from 1.9 to 16.0 per 10 000 children (median 4.5) per year. Influenza-related ED visits ranged from 89 to 620 per 10 000 children (median 143) per year. Significant decreases in hospitalizations (P < .05) and increases in ED visits (P < .05) over time were not clearly related to vaccination trends. Influenza-related encounters were greater when influenza A(H3N2) circulated than during other years with median rates of 8.2 vs 3.2 hospitalizations and 307 vs 143 ED visits per 10 000 children, respectively. CONCLUSIONS: Influenza vaccination increased over time; however, the proportion of fully vaccinated children remained <50%. Influenza was associated with a substantial illness burden particularly when influenza A(H3N2) predominated.
Authors: Marika K Iwane; Kathryn M Edwards; Peter G Szilagyi; Frances J Walker; Marie R Griffin; Geoffrey A Weinberg; Charmaine Coulen; Katherine A Poehling; Laura P Shone; Sharon Balter; Caroline B Hall; Dean D Erdman; Karen Wooten; Benjamin Schwartz Journal: Pediatrics Date: 2004-06 Impact factor: 7.124
Authors: William W Thompson; David K Shay; Eric Weintraub; Lynnette Brammer; Nancy Cox; Larry J Anderson; Keiji Fukuda Journal: JAMA Date: 2003-01-08 Impact factor: 56.272
Authors: William W Thompson; David K Shay; Eric Weintraub; Lynnette Brammer; Carolyn B Bridges; Nancy J Cox; Keiji Fukuda Journal: JAMA Date: 2004-09-15 Impact factor: 56.272
Authors: Peter G Szilagyi; Marika K Iwane; Stanley Schaffer; Sharon G Humiston; Richard Barth; Thomas McInerny; Laura Shone; Benjamin Schwartz Journal: Pediatrics Date: 2003-10 Impact factor: 7.124
Authors: Jay G Berry; Alan M Zaslavsky; Sara L Toomey; Alyna T Chien; Jisun Jang; Maria C Bryant; David J Klein; William J Kaplan; Mark A Schuster Journal: Pediatrics Date: 2015-07-13 Impact factor: 7.124
Authors: Ekaterina Nekrasova; Melissa S Stockwell; Russell Localio; Justine Shults; Chelsea Wynn; Laura P Shone; Lindsay Berrigan; Chelsea Kolff; Miranda Griffith; Andrew Johnson; Alessandra Torres; Douglas J Opel; Alexander G Fiks Journal: Hum Vaccin Immunother Date: 2020-02-04 Impact factor: 3.452
Authors: Mark G Thompson; Jessie Clippard; Joshua G Petrie; Michael L Jackson; Huong Q McLean; Manjusha Gaglani; Evelyn C Reis; Brendan Flannery; Arnold S Monto; Lisa Jackson; Edward A Belongia; Kempapura Murthy; Richard K Zimmerman; Swathi Thaker; Alicia M Fry Journal: Pediatr Infect Dis J Date: 2016-03 Impact factor: 2.129
Authors: Rebecca J Hart; Michelle D Stevenson; Michael J Smith; A Scott LaJoie; Keith Cross Journal: JAMA Pediatr Date: 2018-01-02 Impact factor: 16.193
Authors: Holly M Biggs; Monica McNeal; W Allan Nix; Carolyn Kercsmar; Aaron T Curns; Beverly Connelly; Marilyn Rice; Shur-Wern Wang Chern; Mila M Prill; Nancy Back; M Steven Oberste; Susan I Gerber; Mary A Staat Journal: Clin Infect Dis Date: 2017-07-15 Impact factor: 9.079