Md Mohaimenul Islam1,2, Usman Iqbal2,3, Bruno Andreas Walther3, Phung-Anh Nguyen1,2, Yu-Chuan Jack Li1,2,4, Navneet Kumar Dubey5, Tahmina Nasrin Poly6, Jakir Hossain Bhuiyan Masud1,2, Suleman Atique1,2, Shabbir Syed-Abdul7,8. 1. Graduate Institution of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan. 2. International Center for Health Information Technology (ICHIT), Taipei Medical University, Taipei, Taiwan. 3. Master Program in Global Health and Development, College of Public Health, Taipei Medical University, Taipei, Taiwan. 4. Chair, Department of Dermatology, Wan Fang Hospital, Taipei, Taiwan. 5. Graduate Institute of Biomedical Materials & Tissue Engineering, Taipei Medical University, Taipei, Taiwan. 6. Department of Microbiology and Immunology, Tzu Chi University, Hualien, Taiwan. 7. Graduate Institution of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan. drshabbir@tmu.edu.tw. 8. International Center for Health Information Technology (ICHIT), Taipei Medical University, Taipei, Taiwan. drshabbir@tmu.edu.tw.
Abstract
PURPOSE: In general, male and female are prescribed the same amount of dosage even if most of the cases female required less dosage than male. Physicians are often facing problem on appropriate drug dosing, efficient treatment, and drug safety for a female in general. To identify and synthesize evidence about the effectiveness of gender-based therapy; provide the information to patients, providers, and health system intervention to ensure safety treatment; and minimize adverse effects. METHODS: We performed a systematic review to evaluate the effect of gender difference on pharmacotherapy. Published articles from January 1990 to December 2015 were identified using specific term in MEDLINE (PubMed), EMBASE, and the Cochrane library according to search strategies that strengthen the reporting of observational and clinical studies. RESULTS: Twenty-six studies fulfilled the inclusion criteria for this systematic review, yielding a total of 6309 subjects. We observed that female generally has a lower the gastric emptying time, gastric PH, lean body mass, and higher plasma volume, BMI, body fat, as well as reduce hepatic clearance, difference in activity of Cytochrome P450 enzyme, and metabolize drugs at different rate compared with male. Other significant factors such as conjugation, protein binding, absorption, and the renal elimination could not be ignored. However, these differences can lead to adverse effects in female especially for the pregnant, post-menopausal, and elderly women. CONCLUSION: This systematic review provides an evidence for the effectiveness of dosage difference to ensure safety and efficient treatment. Future studies on the current topic are, therefore, recommended to reduce the adverse effect of therapy.
PURPOSE: In general, male and female are prescribed the same amount of dosage even if most of the cases female required less dosage than male. Physicians are often facing problem on appropriate drug dosing, efficient treatment, and drug safety for a female in general. To identify and synthesize evidence about the effectiveness of gender-based therapy; provide the information to patients, providers, and health system intervention to ensure safety treatment; and minimize adverse effects. METHODS: We performed a systematic review to evaluate the effect of gender difference on pharmacotherapy. Published articles from January 1990 to December 2015 were identified using specific term in MEDLINE (PubMed), EMBASE, and the Cochrane library according to search strategies that strengthen the reporting of observational and clinical studies. RESULTS: Twenty-six studies fulfilled the inclusion criteria for this systematic review, yielding a total of 6309 subjects. We observed that female generally has a lower the gastric emptying time, gastric PH, lean body mass, and higher plasma volume, BMI, body fat, as well as reduce hepatic clearance, difference in activity of Cytochrome P450 enzyme, and metabolize drugs at different rate compared with male. Other significant factors such as conjugation, protein binding, absorption, and the renal elimination could not be ignored. However, these differences can lead to adverse effects in female especially for the pregnant, post-menopausal, and elderly women. CONCLUSION: This systematic review provides an evidence for the effectiveness of dosage difference to ensure safety and efficient treatment. Future studies on the current topic are, therefore, recommended to reduce the adverse effect of therapy.
Entities:
Keywords:
Adverse effect; Drug interaction; Gender-based; Pharmacokinetics; Pharmacotherapy
Authors: Rosa Schmuck; Michael Gerken; Eva-Maria Teegen; Isabell Krebs; Monika Klinkhammer-Schalke; Felix Aigner; Johann Pratschke; Beate Rau; Stefan Benz Journal: Langenbecks Arch Surg Date: 2020-01-31 Impact factor: 3.445
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