Literature DB >> 2837617

Mercury and tetracycline resistance genes and flanking repeats associated with methicillin resistance on the chromosome of Staphylococcus aureus.

S Skinner1, B Inglis, P R Matthews, P R Stewart.   

Abstract

Sections of a cloned 27 kb segment of chromosomal DNA, associated with resistance to four antimicrobial agents in a clinical isolate of methicillin-resistant Staphylococcus aureus (MRSA), were tested for their ability to determine resistance when transformed into a sensitive laboratory strain of S. aureus. This was achieved by inserting the sections into a newly constructed shuttle vector, amplifying the recombinant DNA in E. coli, and transforming protoplasts of the sensitive S. aureus strain. Two sections of the cloned DNA were found to determine resistance separately to mercuric ion and to tetracycline, in both S. aureus and Escherichia coli.

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Year:  1988        PMID： 2837617     DOI： 10.1111/j.1365-2958.1988.tb00030.x

Source DB:  PubMed          Journal:  Mol Microbiol        ISSN： 0950-382X            Impact factor:   3.501


  10 in total

1.  The Staphylococcus aureus mec determinant comprises an unusual cluster of direct repeats and codes for a gene product similar to the Escherichia coli sn-glycerophosphoryl diester phosphodiesterase.

Authors:  C Ryffel; R Bucher; F H Kayser; B Berger-Bächi
Journal:  J Bacteriol       Date:  1991-12       Impact factor: 3.490

2.  epr, which encodes glycylglycine endopeptidase resistance, is homologous to femAB and affects serine content of peptidoglycan cross bridges in Staphylococcus capitis and Staphylococcus aureus.

Authors:  M Sugai; T Fujiwara; K Ohta; H Komatsuzawa; M Ohara; H Suginaka
Journal:  J Bacteriol       Date:  1997-07       Impact factor: 3.490

3.  Molecular cloning and expression in Escherichia coli of bleomycin-resistance gene from a methicillin-resistant Staphylococcus aureus and its association with IS431 mec.

Authors:  M Z Bhuiyan; K Ueda; Y Inouye; M Sugiyama
Journal:  Appl Microbiol Biotechnol       Date:  1995-04       Impact factor: 4.813

4.  Structural comparison of three types of staphylococcal cassette chromosome mec integrated in the chromosome in methicillin-resistant Staphylococcus aureus.

Authors:  T Ito; Y Katayama; K Asada; N Mori; K Tsutsumimoto; C Tiensasitorn; K Hiramatsu
Journal:  Antimicrob Agents Chemother       Date:  2001-05       Impact factor: 5.191

Review 5.  Methicillin-resistant staphylococci: genetics and mechanisms of resistance.

Authors:  C J Hackbarth; H F Chambers
Journal:  Antimicrob Agents Chemother       Date:  1989-07       Impact factor: 5.191

6.  Cloning and nucleotide sequence determination of the entire mec DNA of pre-methicillin-resistant Staphylococcus aureus N315.

Authors:  T Ito; Y Katayama; K Hiramatsu
Journal:  Antimicrob Agents Chemother       Date:  1999-06       Impact factor: 5.191

7.  Molecular and phage typing of Staphylococcus aureus harbouring cryptic conjugative plasmids.

Authors:  E E Udo; W B Grubb
Journal:  Eur J Epidemiol       Date:  1996-12       Impact factor: 8.082

Review 8.  Methicillin resistance in staphylococci: molecular and biochemical basis and clinical implications.

Authors:  H F Chambers
Journal:  Clin Microbiol Rev       Date:  1997-10       Impact factor: 26.132

9.  Characterization of a novel insertion of the macrolides-lincosamides-streptogramin B resistance transposon Tn554 in methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis.

Authors:  L E Tillotson; W D Jenssen; L Moon-McDermott; D T Dubin
Journal:  Antimicrob Agents Chemother       Date:  1989-04       Impact factor: 5.191

10.  Physical mapping of the mec region of an American methicillin-resistant Staphylococcus aureus strain.

Authors:  D T Dubin; P R Matthews; S G Chikramane; P R Stewart
Journal:  Antimicrob Agents Chemother       Date:  1991-08       Impact factor: 5.191
  10 in total

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