Literature DB >> 2837271

Formation of 8-hydroxydeoxyguanosine by asbestos and man made mineral fibres.

P Leanderson1, P Söderkvist, C Tagesson, O Axelson.   

Abstract

Samples of rockwool and glass fibre were compared with chrysotile fibres for their capacity to hydroxylate 2-deoxyguanosine to 8-hydroxydeoxyguanosine, a reaction that is mediated by formation of hydroxyl radicals. All three fibres produced 8-hydroxydeoxyguanosine in the absence of H2O2. The chrysotile fibres were most potent and produced about ten times more of the modified nucleoside than rockwool and glass fibre. This investigation shows that not only asbestos but also man made mineral fibres are able to modify nucleosides.

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Year:  1988        PMID： 2837271      PMCID： PMC1008000          DOI： 10.1136/oem.45.5.309

Source DB:  PubMed          Journal:  Br J Ind Med        ISSN： 0007-1072


  10 in total

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Authors:  H Kasai; S Nishimura
Journal:  Nucleic Acids Res       Date:  1984-02-24       Impact factor: 16.971

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Journal:  Science       Date:  1983-09-23       Impact factor: 47.728
  10 in total
  9 in total

1.  Oxidative DNA damage in peripheral blood lymphocytes of coal workers.

Authors:  R P Schins; P A Schilderman; P J Borm
Journal:  Int Arch Occup Environ Health       Date:  1995       Impact factor: 3.015

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Journal:  Br J Ind Med       Date:  1989-07

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Authors:  V Vallyathan; X Shi
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Journal:  Environ Health Perspect       Date:  1997-09       Impact factor: 9.031

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Journal:  Environ Health Perspect       Date:  1990-08       Impact factor: 9.031

8.  Effects of induction and age-dependent enzyme expression on lung bioavailability, metabolism, and DNA binding of urban air particulate-absorbed benzo[a]pyrene, 2-nitrofluorene, and 3-amino-1,4-dimethyl-5H-pyridol-(4,3)-indole.

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Journal:  Environ Health Perspect       Date:  1994-12       Impact factor: 9.031
  9 in total

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