Hua-Yan Xu1, Jing Chen1,2, Zhi-Gang Yang1, Rui Li1, Ke Shi1, Qin Zhang1, Xi Liu1, Lin-Jun Xie1, Li Jiang1, Ying-Kun Guo3. 1. Department of Radiology, National Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan, P.R. China. 2. Department of Radiology, Affiliated Hospital of Southwest Medical University, Sichuan, P.R. China. 3. Department of Radiology, West China Second University Hospital, Sichuan University, Sichuan, P.R. China.
Abstract
PURPOSE: To evaluate the regional left ventricular (LV) myocardial strain of early stage hypertrophic cardiomyopathy (HCM) patients by magnetic resonance (MR) tissue tracking. MATERIALS AND METHODS: In all, 114 adult HCM patients classified as NYHA I or II and 32 healthy volunteers were enrolled and underwent 3.0T MR examination. Vertical 2-chamber long axis, horizontal 4-chamber, and short axis cine sequence as well as late gadolinium enhancement images (LGE) were scanned. The cardiac function, regional LV tissue tracking variables, end-diastolic wall thickness (EDTH), and LGE extent were measured. RESULTS: In the HCM group, 38 were NYHA I and 76 were NYHA II. By regional analysis, peak strain (PS) and peak displacement (PD) with radial, circumferential direction of hypertrophic segments (n = 283) were significantly lower than nonhypertrophic segments (n = 1541) (all P < 0.05). Radial PS was significantly correlated with LVEDTH (r = -0.467, P < 0.0001). Radial PD was negatively associated with LVEDTH (r = -0.331, P < 0.0001). The PS and PD of all directions were decreased in segments with LGE (n = 723) compared with those without LGE (n = 1101) (all P < 0.05). In addition, radial PS and PD were negatively associated with LGE extent (radial PS, r = -0.441; radial PD, r = -0.274; both P < 0.0001). All strain parameters showed excellent inter- and intraobserver agreements. CONCLUSION: Decreased regional LV myocardial strain hypertrophic and fibrotic segments of early-stage HCM patients can be measured by MR tissue tracking based on routine cine images. Moreover, myocardial strain may decrease with the increasing of myocardial hypertrophy as well as fibrosis. LEVEL OF EVIDENCE: 2 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2017;46:1368-1376.
PURPOSE: To evaluate the regional left ventricular (LV) myocardial strain of early stage hypertrophic cardiomyopathy (HCM) patients by magnetic resonance (MR) tissue tracking. MATERIALS AND METHODS: In all, 114 adult HCM patients classified as NYHA I or II and 32 healthy volunteers were enrolled and underwent 3.0T MR examination. Vertical 2-chamber long axis, horizontal 4-chamber, and short axis cine sequence as well as late gadolinium enhancement images (LGE) were scanned. The cardiac function, regional LV tissue tracking variables, end-diastolic wall thickness (EDTH), and LGE extent were measured. RESULTS: In the HCM group, 38 were NYHA I and 76 were NYHA II. By regional analysis, peak strain (PS) and peak displacement (PD) with radial, circumferential direction of hypertrophic segments (n = 283) were significantly lower than nonhypertrophic segments (n = 1541) (all P < 0.05). Radial PS was significantly correlated with LVEDTH (r = -0.467, P < 0.0001). Radial PD was negatively associated with LVEDTH (r = -0.331, P < 0.0001). The PS and PD of all directions were decreased in segments with LGE (n = 723) compared with those without LGE (n = 1101) (all P < 0.05). In addition, radial PS and PD were negatively associated with LGE extent (radial PS, r = -0.441; radial PD, r = -0.274; both P < 0.0001). All strain parameters showed excellent inter- and intraobserver agreements. CONCLUSION: Decreased regional LV myocardial strain hypertrophic and fibrotic segments of early-stage HCM patients can be measured by MR tissue tracking based on routine cine images. Moreover, myocardial strain may decrease with the increasing of myocardial hypertrophy as well as fibrosis. LEVEL OF EVIDENCE: 2 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2017;46:1368-1376.