Literature DB >> 28370655

Detection of DT-diaphorase Enzyme with a ParaCEST MRI Contrast Agent.

Iman Daryaei1, Kyle M Jones2, Mark D Pagel3.   

Abstract

A responsive magnetic resonance (MRI) contrast agent has been developed that can detect the enzyme activity of DT-diaphorase. The agent produced different chemical exchange saturation transfer (CEST) MRI signals before and after incubation with the enzyme, NADH, and GSH at different pH values whereas it showed good stability in a reducing environment without enzyme.
© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  CEST MRI; NQO1; dt-diaphorase; molecular imaging; trimethyl lock

Mesh：

Substances：

Year:  2017        PMID： 28370655      PMCID： PMC6010184          DOI： 10.1002/chem.201700721

Source DB:  PubMed          Journal:  Chemistry        ISSN： 0947-6539            Impact factor:   5.236


  38 in total

Review 1.  DT-diaphorase and cancer chemotherapy.

Authors:  R J Riley; P Workman
Journal:  Biochem Pharmacol       Date:  1992-04-15       Impact factor: 5.858

Review 2.  Prodrug applications for targeted cancer therapy.

Authors:  Irene Giang; Erin L Boland; Gregory M K Poon
Journal:  AAPS J       Date:  2014-07-09       Impact factor: 4.009

3.  Improved pH measurements with a single PARACEST MRI contrast agent.

Authors:  Vipul R Sheth; Guanshu Liu; Yuguo Li; Mark D Pagel
Journal:  Contrast Media Mol Imaging       Date:  2012 Jan-Feb       Impact factor: 3.161

4.  A self-calibrating PARACEST MRI contrast agent that detects esterase enzyme activity.

Authors:  Yuguo Li; Vipul R Sheth; Guanshu Liu; Mark D Pagel
Journal:  Contrast Media Mol Imaging       Date:  2010-11-30       Impact factor: 3.161

5.  Imaging in vivo extracellular pH with a single paramagnetic chemical exchange saturation transfer magnetic resonance imaging contrast agent.

Authors:  Guanshu Liu; Yuguo Li; Vipul R Sheth; Mark D Pagel
Journal:  Mol Imaging       Date:  2012-02       Impact factor: 4.488

6.  Measuring in vivo tumor pHe with CEST-FISP MRI.

Authors:  Vipul R Sheth; Yuguo Li; Liu Qi Chen; Christine M Howison; Chris A Flask; Mark D Pagel
Journal:  Magn Reson Med       Date:  2011-10-25       Impact factor: 4.668

Review 7.  The role of NAD(P)H oxidoreductase (DT-Diaphorase) in the bioactivation of quinone-containing antitumor agents: a review.

Authors:  P L Gutierrez
Journal:  Free Radic Biol Med       Date:  2000-08       Impact factor: 7.376

8.  Bioreductive activation of mitomycin C by DT-diaphorase.

Authors:  D Siegel; H Beall; C Senekowitsch; M Kasai; H Arai; N W Gibson; D Ross
Journal:  Biochemistry       Date:  1992-09-01       Impact factor: 3.162

9.  Trimethyl lock: A trigger for molecular release in chemistry, biology, and pharmacology.

Authors:  Michael N Levine; Ronald T Raines
Journal:  Chem Sci       Date:  2012-05-30       Impact factor: 9.825

10.  Detection and cellular imaging of human cancer enzyme using a turn-on, wavelength-shiftable, self-immolative profluorophore.

Authors:  Suraj U Hettiarachchi; Bijeta Prasai; Robin L McCarley
Journal:  J Am Chem Soc       Date:  2014-05-14       Impact factor: 15.419
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  2 in total

Review 1.  Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers.

Authors:  Jessica Wahsner; Eric M Gale; Aurora Rodríguez-Rodríguez; Peter Caravan
Journal:  Chem Rev       Date:  2018-10-16       Impact factor: 60.622

2.  Novel nanomedicine with a chemical-exchange saturation transfer effect for breast cancer treatment in vivo.

Authors:  Yanlong Jia; Chaochao Wang; Jiehua Zheng; Guisen Lin; Dalong Ni; Zhiwei Shen; Baoxuan Huang; Yan Li; Jitian Guan; Weida Hong; Yuanfeng Chen; Renhua Wu
Journal:  J Nanobiotechnology       Date:  2019-12-17       Impact factor: 10.435
  2 in total

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