Toke de Koning Svendsen1,2, Peter Nørregaard Hansen1,2, Luis Alberto García Rodríguez3, Lene Andersen1,2, Jesper Hallas4,5, Søren Hein Sindrup1,2, David Gaist1,2. 1. Department of Neurology, Odense University Hospital, Odense, Denmark. 2. Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark. 3. Centro Español de Investigación Farmacoepidemiológica (CEIFE), Madrid, Spain. 4. Department of Clinical Pharmacology, Odense University Hospital, Odense, Denmark. 5. Institute of Public Health, University of Southern Denmark, Odense, Denmark.
Abstract
AIM: In a previous study, we found a positive association between statin use and polyneuropathy risk. Other studies reported equivocal results. The present study aimed to confirm our findings with a design similar to that used in our previous study but with a larger data set. METHODS: We searched medical registry data to identify patients diagnosed with incident polyneuropathy of no known cause (idiopathic polyneuropathy) between 1999 and 2013; we verified diagnoses through medical records. For each case, we recruited 20 general population controls with no previous history of polyneuropathy. Controls were matched to their respective case for age and gender. We ascertained the prior statin use of cases and controls through a prescription registry. Based on this information, exposure to statins was categorized into 'ever use' or 'never use'. Ever use of statins was classified by how recently they had been used ('current use' or 'past use'); current use was further classified into long-term use (5+ years) and high- or low-intensity use. We used conditional logistic regression to calculate odds ratios (ORs) with 95% confidence intervals (CIs) to examine associations between polyneuropathy and statin use. RESULTS: We included 370 validated cases and 7400 controls. Ever use of statins was not associated with an elevated risk of polyneuropathy (OR 1.14, 95% CI 0.84, 1.54). Similarly, we found no associations between polyneuropathy risk and current use (OR 1.11, 95% CI 0.79, 1.53), long-term use (OR 1.13, 95% CI 0.66, 1.92) or high-intensity statin use (OR 1.05, 95% CI 0.59, 1.84). CONCLUSION: Statin use was not associated with an increased risk of idiopathic polyneuropathy.
AIM: In a previous study, we found a positive association between statin use and polyneuropathy risk. Other studies reported equivocal results. The present study aimed to confirm our findings with a design similar to that used in our previous study but with a larger data set. METHODS: We searched medical registry data to identify patients diagnosed with incident polyneuropathy of no known cause (idiopathic polyneuropathy) between 1999 and 2013; we verified diagnoses through medical records. For each case, we recruited 20 general population controls with no previous history of polyneuropathy. Controls were matched to their respective case for age and gender. We ascertained the prior statin use of cases and controls through a prescription registry. Based on this information, exposure to statins was categorized into 'ever use' or 'never use'. Ever use of statins was classified by how recently they had been used ('current use' or 'past use'); current use was further classified into long-term use (5+ years) and high- or low-intensity use. We used conditional logistic regression to calculate odds ratios (ORs) with 95% confidence intervals (CIs) to examine associations between polyneuropathy and statin use. RESULTS: We included 370 validated cases and 7400 controls. Ever use of statins was not associated with an elevated risk of polyneuropathy (OR 1.14, 95% CI 0.84, 1.54). Similarly, we found no associations between polyneuropathy risk and current use (OR 1.11, 95% CI 0.79, 1.53), long-term use (OR 1.13, 95% CI 0.66, 1.92) or high-intensity statin use (OR 1.05, 95% CI 0.59, 1.84). CONCLUSION: Statin use was not associated with an increased risk of idiopathic polyneuropathy.
Authors: L L Teunissen; H Franssen; J H J Wokke; Y van der Graaf; W H J P Linssen; J D Banga; D M Laman; N C Notermans Journal: J Neurol Neurosurg Psychiatry Date: 2002-05 Impact factor: 10.154
Authors: Toke de Koning Svendsen; Peter Nørregaard Hansen; Luis Alberto García Rodríguez; Lene Andersen; Jesper Hallas; Søren Hein Sindrup; David Gaist Journal: Br J Clin Pharmacol Date: 2017-05-11 Impact factor: 4.335
Authors: Alex Molassiotis; Hui Lin Cheng; Kwun To Leung; Yu Chung Li; Kam Hung Wong; Joseph Siu Kie Au; Raghav Sundar; Alexandre Chan; Terrence Rong De Ng; Lorna K P Suen; Choi Wan Chan; Janelle Yorke; Violeta Lopez Journal: Brain Behav Date: 2019-05-07 Impact factor: 2.708