Cornelis J de Groot1, Adriaan van den Berg1, Bart E P B Ballieux2, Herman M Kroon3, Edmond H H M Rings1,4, Jan M Wit1, Erica L T van den Akker4. 1. Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, the Netherlands. 2. Department of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, the Netherlands. 3. Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands. 4. Sophia Children's Hospital, Erasmus University Medical Center, Rotterdam, the Netherlands.
Abstract
BACKGROUND: Childhood obesity is associated with advanced bone age (BA). Previous studies suggest that androgens, oestrogens, sex hormone-binding globulin, and insulin are responsible for this phenomenon, but results are contradictory and might be biased by confounders. We aim to elucidate this matter by applying a multivariate approach. METHOD: We performed a correlation analysis of BA standard deviation score (SDS) with age- and sex-specific SDS for androgens, oestrogens, and with indicators of insulin secretion derived from oral glucose tolerance testing, in a group of obese children. A multivariate analysis was performed to investigate which parameters were independently predictive of BA SDS. RESULTS: In this cohort (n = 101; mean age 10.9 years; mean BA 11.8 years; mean BMI SDS 3.3), BMI SDS was significantly correlated to BA SDS (r = 0.55, p < 0.001). In a regression analysis in the total cohort (B = 0.27, p < 0.001) as well as in females (B = 0.34, p = 0.042), males (B = 0.31, p = 0.006), and pubertal children (B = 0.32, p = 0.046), dehydroepiandrosterone sulphate (DHEAS) showed a positive, independent association with BA SDS. No association with indicators of insulin secretion was found. CONCLUSION: BMI SDS is highly correlated to BA SDS in obese children. Increased DHEAS has a central role in advanced BA in obese children. . The Author(s). Published by S. Karger AG, Basel.
BACKGROUND: Childhood obesity is associated with advanced bone age (BA). Previous studies suggest that androgens, oestrogens, sex hormone-binding globulin, and insulin are responsible for this phenomenon, but results are contradictory and might be biased by confounders. We aim to elucidate this matter by applying a multivariate approach. METHOD: We performed a correlation analysis of BA standard deviation score (SDS) with age- and sex-specific SDS for androgens, oestrogens, and with indicators of insulin secretion derived from oral glucose tolerance testing, in a group of obesechildren. A multivariate analysis was performed to investigate which parameters were independently predictive of BASDS. RESULTS: In this cohort (n = 101; mean age 10.9 years; mean BA 11.8 years; mean BMI SDS 3.3), BMI SDS was significantly correlated to BASDS (r = 0.55, p < 0.001). In a regression analysis in the total cohort (B = 0.27, p < 0.001) as well as in females (B = 0.34, p = 0.042), males (B = 0.31, p = 0.006), and pubertal children (B = 0.32, p = 0.046), dehydroepiandrosterone sulphate (DHEAS) showed a positive, independent association with BASDS. No association with indicators of insulin secretion was found. CONCLUSION: BMI SDS is highly correlated to BASDS in obesechildren. Increased DHEAS has a central role in advanced BA in obesechildren. . The Author(s). Published by S. Karger AG, Basel.
Entities:
Keywords:
Androgens; Bone age; Dehydroepiandrosterone ; Insulin; Obesity
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