Literature DB >> 2836203

Clinical evaluation of 99mTc(V)-dimercapto succinic acid (DMSA) for imaging medullary carcinoma of thyroid and its metastasis.

M C Patel1, R B Patel, P Ramanathan, N Ramamoorthy, B A Krishna, S M Sharma.   

Abstract

99mTc(V)-DMSA kits developed by the Radiopharmaceutical Division, Bhabha Atomic Research Centre, have been evaluated for potential use in scanning medullary carcinoma of the thyroid and its metastases. There were 15 patients with proved medullary carcinoma and 6 patients with other differentiated thyroid carcinoma. Amongst the 15 patients with medullary carcinoma, 12 (80%) showed positive localisation either in the primary or one or more metastatic sites. None of the six patients with carcinoma other than medullary showed increased concentration of 99mTc(V)-DMSA. Of the 37 known metastatic sites in 15 patients with medullary carcinoma, 24 showed concentration of 99mTc(V)-DMSA (64.9%). In addition, 99mTc(V)-DMSA concentration was seen in 14 sites where no evidence of metastasis was revealed. The incidence of 99mTc(V)-DMSA concentration in soft tissue and bone metastasis was similar.

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Year:  1988        PMID： 2836203     DOI： 10.1007/BF00256625

Source DB:  PubMed          Journal:  Eur J Nucl Med        ISSN： 0340-6997


  8 in total

1.  Early diagnosis of medullary carcinoma of the thyroid gland by means of calcitonin assay.

Authors:  K E Melvin; H H Miller; A H Tashjian
Journal:  N Engl J Med       Date:  1971-11       Impact factor: 91.245

2.  Preparation and evaluation of 99mTc(V)-DMSA complex: studies in medullary carcinoma of thyroid.

Authors:  N Ramamoorthy; S V Shetye; P M Pandey; R S Mani; M C Patel; R B Patel; P Ramanathan; B A Krishna; S M Sharma
Journal:  Eur J Nucl Med       Date:  1987

3.  The design of a pentavalent 99mTc-dimercaptosuccinate complex as a tumor imaging agent.

Authors:  A Yokoyama; N Hata; K Horiuchi; H Masuda; H Saji; H Ohta; K Yamamoto; K Endo; K Torizuka
Journal:  Int J Nucl Med Biol       Date:  1985

4.  Poor results with technetium-99m (V) DMS and iodine-131 MIBG in the imaging of medullary thyroid carcinoma.

Authors:  T E Hilditch; J M Connell; A T Elliot; T Murray; N S Reed
Journal:  J Nucl Med       Date:  1986-07       Impact factor: 10.057

5.  A new imaging agent for medullary carcinoma of the thyroid.

Authors:  H Ohta; K Yamamoto; K Endo; T Mori; D Hamanaka; A Shimazu; K Ikekubo; K Makimoto; Y Iida; J Konishi
Journal:  J Nucl Med       Date:  1984-03       Impact factor: 10.057

6.  Thyroid scintigram in familial medullary carcinoma of the thyroid gland.

Authors:  R J Anderson; G W Sizemore; H W Wahner; J A Carney
Journal:  Clin Nucl Med       Date:  1978-04       Impact factor: 7.794

7.  Imaging of soft tissue tumors with Tc(V)-99m dimercaptosuccinic acid. A new tumor-seeking agent.

Authors:  H Ohta; K Endo; T Fujita; T Nakajima; H Sakahara; K Torizuka; Y Shimizu; N Hata; H Masuda; K Horiuchi
Journal:  Clin Nucl Med       Date:  1984-10       Impact factor: 7.794

8.  A convenient method for the preparation of 99mTc(V)dimercaptosuccinic acid (99mTc(V)-DMSA).

Authors:  G Westera; A Gadze; W Horst
Journal:  Int J Appl Radiat Isot       Date:  1985-04
  8 in total
  3 in total

1.  Search for polynuclear pentavalent technetium complex of dimercaptosuccinic acid [Tc(V)-DMS] tumour localization mechanism. I. Medullary thyroid carcinoma animal model.

Authors:  K Horiuchi; I Yomoda; H Ohta; K Endo; A Yokoyama
Journal:  Eur J Nucl Med       Date:  1991

2.  In vitro and in vivo studies with pentavalent technetium-99m dimercaptosuccinic acid.

Authors:  A S Lam; M R Puncher; P J Blower
Journal:  Eur J Nucl Med       Date:  1996-12

3.  Scintigraphic detection of recurrence of medullary thyroid cancer.

Authors:  M Koizumi; Y Yamada; E Nomura; M Amano; Y Okajima; H Okizuka; K Yamada; S Sawano; T Kitahara; T Yamashita
Journal:  Ann Nucl Med       Date:  1995-05       Impact factor: 2.668
  3 in total

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