Literature DB >> 28361897

Spontaneous DNA damage propels tumorigenicity.

Ilio Vitale1,2, Guido Kroemer3,4,5,6,7,8,9.   

Abstract

High levels of endogenously generated DNA damage drive oncogenesis, sustain malignant progression and increase therapy resistance. In a paper recently published in Cell Research, Liu and colleagues added additional insights into this topic by uncovering a novel intrinsic source of double-strand breaks that fosters the aggressiveness and stemness of malignant cells.

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Year:  2017        PMID： 28361897      PMCID： PMC5518871          DOI： 10.1038/cr.2017.43

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  12 in total

Review 1.  DNA damage sensing by the ATM and ATR kinases.

Authors:  Alexandre Maréchal; Lee Zou
Journal:  Cold Spring Harb Perspect Biol       Date:  2013-09-01       Impact factor: 10.005

Review 2.  Karyotypic Aberrations in Oncogenesis and Cancer Therapy.

Authors:  Ilio Vitale; Gwenola Manic; Laura Senovilla; Guido Kroemer; Lorenzo Galluzzi
Journal:  Trends Cancer       Date:  2015-10-01

Review 3.  DNA damage repair pathways in cancer stem cells.

Authors:  Marcello Maugeri-Saccà; Monica Bartucci; Ruggero De Maria
Journal:  Mol Cancer Ther       Date:  2012-07-25       Impact factor: 6.261

Review 4.  Causes and consequences of replication stress.

Authors:  Michelle K Zeman; Karlene A Cimprich
Journal:  Nat Cell Biol       Date:  2014-01       Impact factor: 28.824

Review 5.  Targeting the DNA Damage Response in Cancer.

Authors:  Mark J O'Connor
Journal:  Mol Cell       Date:  2015-11-19       Impact factor: 17.970

Review 6.  An oncogene-induced DNA damage model for cancer development.

Authors:  Thanos D Halazonetis; Vassilis G Gorgoulis; Jiri Bartek
Journal:  Science       Date:  2008-03-07       Impact factor: 47.728

7.  Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations.

Authors:  Aniek Janssen; Marja van der Burg; Karoly Szuhai; Geert J P L Kops; René H Medema
Journal:  Science       Date:  2011-09-30       Impact factor: 47.728

8.  Limited mitochondrial permeabilization causes DNA damage and genomic instability in the absence of cell death.

Authors:  Gabriel Ichim; Jonathan Lopez; Shafiq U Ahmed; Nathiya Muthalagu; Evangelos Giampazolias; M Eugenia Delgado; Martina Haller; Joel S Riley; Susan M Mason; Dimitris Athineos; Melissa J Parsons; Bert van de Kooij; Lisa Bouchier-Hayes; Anthony J Chalmers; Rogier W Rooswinkel; Andrew Oberst; Karen Blyth; Markus Rehm; Daniel J Murphy; Stephen W G Tait
Journal:  Mol Cell       Date:  2015-02-19       Impact factor: 17.970

9.  Self-inflicted DNA double-strand breaks sustain tumorigenicity and stemness of cancer cells.

Authors:  Xinjian Liu; Fang Li; Qian Huang; Zhengxiang Zhang; Ling Zhou; Yu Deng; Min Zhou; Donald E Fleenor; He Wang; Michael B Kastan; Chuan-Yuan Li
Journal:  Cell Res       Date:  2017-03-24       Impact factor: 25.617

10.  CHK1-targeted therapy to deplete DNA replication-stressed, p53-deficient, hyperdiploid colorectal cancer stem cells.

Authors:  Gwenola Manic; Michele Signore; Antonella Sistigu; Ilio Vitale; Ruggero De Maria; Giorgio Russo; Francesca Corradi; Silvia Siteni; Martina Musella; Sara Vitale; Maria Laura De Angelis; Matteo Pallocca; Carla Azzurra Amoreo; Francesca Sperati; Simone Di Franco; Sabina Barresi; Eleonora Policicchio; Gabriele De Luca; Francesca De Nicola; Marcella Mottolese; Ann Zeuner; Maurizio Fanciulli; Giorgio Stassi; Marcello Maugeri-Saccà; Marta Baiocchi; Marco Tartaglia
Journal:  Gut       Date:  2017-04-07       Impact factor: 23.059
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