Literature DB >> 28361895

Cell fate conversion: a chromatin remodeling checkpoint revealed.

Kenneth S Zaret1.   

Abstract

In a new paper in Cell Research, Ji et al. find that transcription factor-instigated opening of chromatin, during cell reprogramming, can be sensed by the Baf60b-containing chromatin remodeling complex, which then activates the ATM-p53 pathway, leading to cell death. These findings from reprogramming studies unveil what I term a "chromatin remodeling checkpoint" whereby extensive, inappropriate chromatin opening events lead to cell elimination, thus preventing cell fate conversion that might occur upon tissue damage; if unchecked, such conversion could lead to metaplasia and cancer.

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Year:  2017        PMID： 28361895      PMCID： PMC5520856          DOI： 10.1038/cr.2017.44

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  8 in total

1.  A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity.

Authors:  Rosa M Marión; Katerina Strati; Han Li; Matilde Murga; Raquel Blanco; Sagrario Ortega; Oscar Fernandez-Capetillo; Manuel Serrano; Maria A Blasco
Journal:  Nature       Date:  2009-08-09       Impact factor: 49.962

2.  Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors.

Authors:  Pengyu Huang; Zhiying He; Shuyi Ji; Huawang Sun; Dao Xiang; Changcheng Liu; Yiping Hu; Xin Wang; Lijian Hui
Journal:  Nature       Date:  2011-05-11       Impact factor: 49.962

3.  Cooperative Binding of Transcription Factors Orchestrates Reprogramming.

Authors:  Constantinos Chronis; Petko Fiziev; Bernadett Papp; Stefan Butz; Giancarlo Bonora; Shan Sabri; Jason Ernst; Kathrin Plath
Journal:  Cell       Date:  2017-01-19       Impact factor: 41.582

4.  Linking the p53 tumour suppressor pathway to somatic cell reprogramming.

Authors:  Teruhisa Kawamura; Jotaro Suzuki; Yunyuan V Wang; Sergio Menendez; Laura Batlle Morera; Angel Raya; Geoffrey M Wahl; Juan Carlos Izpisúa Belmonte
Journal:  Nature       Date:  2009-08-09       Impact factor: 49.962

5.  Facilitators and impediments of the pluripotency reprogramming factors' initial engagement with the genome.

Authors:  Abdenour Soufi; Greg Donahue; Kenneth S Zaret
Journal:  Cell       Date:  2012-11-15       Impact factor: 41.582

6.  Hnf4α is a key gene that can generate columnar metaplasia in oesophageal epithelium.

Authors:  Benjamin J Colleypriest; Zoë D Burke; Leonard P Griffiths; Yu Chen; Wei-Yuan Yu; Ramiro Jover; Michael Bock; Leigh Biddlestone; Jonathan M Quinlan; Stephen G Ward; J Mark Farrant; Jonathan M W Slack; David Tosh
Journal:  Differentiation       Date:  2016-11-19       Impact factor: 3.880

7.  Baf60b-mediated ATM-p53 activation blocks cell identity conversion by sensing chromatin opening.

Authors:  Shuyi Ji; Linying Zhu; Yimeng Gao; Xiaoran Zhang; Yupeng Yan; Jin Cen; Rongxia Li; Rong Zeng; Lujian Liao; Chunhui Hou; Yawei Gao; Shaorong Gao; Gang Wei; Lijian Hui
Journal:  Cell Res       Date:  2017-03-17       Impact factor: 25.617

Review 8.  Metaplasia and transdifferentiation: from pure biology to the clinic.

Authors:  Jonathan M W Slack
Journal:  Nat Rev Mol Cell Biol       Date:  2007-03-21       Impact factor: 94.444
  8 in total
  1 in total

1.  Histone Epigenetic Signatures in Embryonic Limb Interdigital Cells Fated to Die.

Authors:  Cristina Sanchez-Fernandez; Carlos I Lorda-Diez; Cristina Duarte-Olivenza; Juan M Hurle; Juan A Montero
Journal:  Cells       Date:  2021-04-15       Impact factor: 6.600
  1 in total

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