Literature DB >> 28361318

Generation of a Three-Dimensional Kidney Structure from Pluripotent Stem Cells.

Yasuhiro Yoshimura1, Atsuhiro Taguchi1, Ryuichi Nishinakamura2.   

Abstract

The kidney is a vital organ that has an important role in the maintenance of homeostasis by fluid volume regulation and waste product excretion. This role cannot be performed without the three-dimensional (3D) structure of the kidney. Therefore, it is important to generate the 3D structure of the kidney when inducing functional kidney tissue or the whole organ from pluripotent stem cells. In this chapter, we describe the detailed methods to induce kidney progenitor cells from pluripotent stem cells, which are based on embryological development. We also provide a method to generate 3D kidney tissue with vascularized glomeruli upon transplantation.

Keywords:  Human-induced pluripotent stem cells; Mouse embryonic stem cells; Nephron progenitor cells; Three-dimensional kidney structure; Transplantation

Mesh：

Year:  2017        PMID： 28361318     DOI： 10.1007/978-1-4939-6949-4_13

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  5 in total

1.  In Vivo Developmental Trajectories of Human Podocyte Inform In Vitro Differentiation of Pluripotent Stem Cell-Derived Podocytes.

Authors:  Tracy Tran; Nils O Lindström; Andrew Ransick; Guilherme De Sena Brandine; Qiuyu Guo; Albert D Kim; Balint Der; Janos Peti-Peterdi; Andrew D Smith; Matthew Thornton; Brendan Grubbs; Jill A McMahon; Andrew P McMahon
Journal:  Dev Cell       Date:  2019-07-01       Impact factor: 12.270

2.  Manipulation of Nephron-Patterning Signals Enables Selective Induction of Podocytes from Human Pluripotent Stem Cells.

Authors:  Yasuhiro Yoshimura; Atsuhiro Taguchi; Shunsuke Tanigawa; Junji Yatsuda; Tomomi Kamba; Satoru Takahashi; Hidetake Kurihara; Masashi Mukoyama; Ryuichi Nishinakamura
Journal:  J Am Soc Nephrol       Date:  2019-01-11       Impact factor: 10.121

3.  Organoids from Nephrotic Disease-Derived iPSCs Identify Impaired NEPHRIN Localization and Slit Diaphragm Formation in Kidney Podocytes.

Authors:  Shunsuke Tanigawa; Mazharul Islam; Sazia Sharmin; Hidekazu Naganuma; Yasuhiro Yoshimura; Fahim Haque; Takumi Era; Hitoshi Nakazato; Koichi Nakanishi; Tetsushi Sakuma; Takashi Yamamoto; Hidetake Kurihara; Atsuhiro Taguchi; Ryuichi Nishinakamura
Journal:  Stem Cell Reports       Date:  2018-08-30       Impact factor: 7.765

4.  Impaired NEPHRIN localization in kidney organoids derived from nephrotic patient iPS cells.

Authors:  Tomoko Ohmori; Shankhajit De; Shunsuke Tanigawa; Koichiro Miike; Mazharul Islam; Minami Soga; Takumi Era; Shinichi Shiona; Koichi Nakanishi; Hitoshi Nakazato; Ryuichi Nishinakamura
Journal:  Sci Rep       Date:  2021-02-17       Impact factor: 4.379

5.  Activin Is Superior to BMP7 for Efficient Maintenance of Human iPSC-Derived Nephron Progenitors.

Authors:  Shunsuke Tanigawa; Hidekazu Naganuma; Yusuke Kaku; Takumi Era; Tetsushi Sakuma; Takashi Yamamoto; Atsuhiro Taguchi; Ryuichi Nishinakamura
Journal:  Stem Cell Reports       Date:  2019-08-01       Impact factor: 7.765
  5 in total

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