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Literature DB >> 2836079

The stability of chromosomes in yeast.

V L Larionov¹, T S Karpova, G A Zhouravleva, O B Pashina, N T Nikolaishvili, N Y Kouprina.

Abstract

CL mutants with high instability of chromosome III were UV-induced in haploid strain disomic for chromosome III. The obtained CL mutants can be divided into two groups: (1) CL2, CL3, CL7, CL11-CL13 with elevated level of spontaneous inter- and intragenic recombination and (2) CL4, CL8 in which instability of chromosome III is not accompanied by elevation of mitotic recombination frequency. CL4 and CL8 mutants also show unstable maintenance of artificial minichromosomes with different chromosomal replicators and centromeric loci. The instability of chromosome III and minichromosomes in CL4 and CL8 is determined by two nonallelic genes designated ch14 and ch18. The role of ch14 and ch18 genes in mitotic chromosome transmission is discussed.

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DNA Restriction Enzymes

Year: 1987 PMID： 2836079 DOI： 10.1007/BF00384604

Source DB: PubMed Journal: Curr Genet ISSN： 0172-8083 Impact factor: 3.886

24 in total

7. SMC1: an essential yeast gene encoding a putative head-rod-tail protein is required for nuclear division and defines a new ubiquitous protein family.

Authors: A V Strunnikov; V L Larionov; D Koshland
Journal: J Cell Biol Date: 1993-12 Impact factor: 10.539

7 in total

The stability of chromosomes in yeast.

1. Characterization of a mutation in yeast causing nonrandom chromosome loss during mitosis.

2. Construction of multicopy yeast plasmids with regulated centromere function.

3. A mutant of Saccharomyces cerevisiae with impaired maintenance of centromeric plasmids.

4. Yeast centromeres: structure and function.

5. Determination of probability of plasmid loss per generation.

6. Mutants of S. cerevisiae defective in the maintenance of minichromosomes.

7. Isolation and subcloning analysis of functional centromere DNA (CEN11) from Saccharomyces cerevisiae chromosome XI.

8. A gene required for the separation of chromosomes on the spindle apparatus in yeast.

9. Mitotic chromosome loss in a radiation-sensitive strain of the yeast Saccharomyces cerevisiae.

10. Isolation of a yeast centromere and construction of functional small circular chromosomes.

1. A direct selection procedure for isolating yeast mutants with an impaired segregation of artificial minichromosomes.

2. Ctf3p, the Mis6 budding yeast homolog, interacts with Mcm22p and Mcm16p at the yeast outer kinetochore.

3. Mitotic hyperploidy for chromosomes VIII and III in Saccharomyces cerevisiae.

4. CHL12, a gene essential for the fidelity of chromosome transmission in the yeast Saccharomyces cerevisiae.

5. CTF4 (CHL15) mutants exhibit defective DNA metabolism in the yeast Saccharomyces cerevisiae.

6. Identification and cloning of the CHL4 gene controlling chromosome segregation in yeast.

7. SMC1: an essential yeast gene encoding a putative head-rod-tail protein is required for nuclear division and defines a new ubiquitous protein family.