| Literature DB >> 28359792 |
Masaki Meguro1, Satoru Miyauchi2, Yukiko Kanao2, Satoru Naito2, Kanae Suzuki2, Shinichi Inoue2, Keisuke Yamada2, Tsuyoshi Homma2, Kiyoshi Chiba2, Futoshi Nara2, Shinji Furuzono2.
Abstract
2,2,2-Trifluoro-1-{4-[(4-fluorophenyl)amino]pyrimidin-5-yl}-1-[1-(methylsulfonyl)piperidin-4-yl]ethanol 1 was identified as a novel potent aldosterone synthase inhibitor. Despite large species differences, compound 1 inhibits both human and rodent CYP11B2 in a nano-molar range.Entities:
Keywords: Aldosterone; Aldosterone synthase inhibitor; Amino-pyrimidine; CYP11B1; CYP11B2
Mesh：
Substances：
Year: 2017 PMID： 28359792 DOI： 10.1016/j.bmcl.2017.03.034
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823