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Literature DB >> 30717606

Human cytochrome P450 enzymes 5-51 as targets of drugs and natural and environmental compounds: mechanisms, induction, and inhibition - toxic effects and benefits.

Slobodan P Rendic¹, F Peter Guengerich².

Abstract

Cytochrome P450 (P450, CYP) enzymes have long been of interest due to their roles in the metabolism of drugs, pesticides, pro-carcinogens, and other xenobiotic chemicals. They have also been of interest due to their very critical roles in the biosynthesis and metabolism of steroids, vitamins, and certain eicosanoids. This review covers the 22 (of the total of 57) human P450s in Families 5-51 and their substrate selectivity. Furthermore, included is information and references regarding inducibility, inhibition, and (in some cases) stimulation by chemicals. We update and discuss important aspects of each of these 22 P450s and questions that remain open.

Entities: Chemical Gene Species

Keywords: Cytochrome P450; eicosanoids; endogenous compounds; enzyme induction; enzyme inhibition; retinoids; steroids; vitamin A; vitamin D; xenobiotics

Mesh：

Substances：

Year: 2018 PMID： 30717606 PMCID： PMC6421578 DOI： 10.1080/03602532.2018.1483401

Source DB: PubMed Journal: Drug Metab Rev ISSN： 0360-2532 Impact factor: 4.518

849 in total

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