V Gupta1, G K Walia2, M P Sachdeva1. 1. Department of Anthropology, University of Delhi, Delhi 110007, India. 2. Public Health Foundation of India, Gurgaon 122002, India.
Abstract
OBJECTIVES: To assess the current status of Mendelian randomization (MR) approach in effectively influencing the observational epidemiology for examining causal relationships. METHODS: Narrative review on studies related to principle, strengths, limitations, and achievements of MR approach. RESULTS: Observational epidemiological studies have repeatedly produced several beneficiary associations which were discarded when tested by standard randomized controlled trials (RCTs). The technique which is more feasible, highly similar to RCTs, and has the potential to establish a causal relationship between modifiable exposures and disease outcomes is known as MR. The technique uses genetic variants related to modifiable traits/exposures as instruments for detecting causal and directional associations with outcomes. CONCLUSIONS: In the last decade, the approach of MR has methodologically developed and progressed to a stage of high acceptance among the epidemiologists and is gradually expanding the landscape of causal relationships in non-communicable chronic diseases.
OBJECTIVES: To assess the current status of Mendelian randomization (MR) approach in effectively influencing the observational epidemiology for examining causal relationships. METHODS: Narrative review on studies related to principle, strengths, limitations, and achievements of MR approach. RESULTS: Observational epidemiological studies have repeatedly produced several beneficiary associations which were discarded when tested by standard randomized controlled trials (RCTs). The technique which is more feasible, highly similar to RCTs, and has the potential to establish a causal relationship between modifiable exposures and disease outcomes is known as MR. The technique uses genetic variants related to modifiable traits/exposures as instruments for detecting causal and directional associations with outcomes. CONCLUSIONS: In the last decade, the approach of MR has methodologically developed and progressed to a stage of high acceptance among the epidemiologists and is gradually expanding the landscape of causal relationships in non-communicable chronic diseases.
Authors: Alireza Moayyeri; Ching-Lung Cheung; Kathryn Cb Tan; John A Morris; Agustin Cerani; Robert P Mohney; J Brent Richards; Christopher Hammond; Tim D Spector; Cristina Menni Journal: J Bone Miner Res Date: 2018-01-26 Impact factor: 6.741
Authors: Yazhou He; Maria Timofeeva; Susan M Farrington; Peter Vaughan-Shaw; Victoria Svinti; Marion Walker; Lina Zgaga; Xiangrui Meng; Xue Li; Athina Spiliopoulou; Xia Jiang; Elina Hyppönen; Peter Kraft; Douglas P Kiel; Caroline Hayward; Archie Campbell; David Porteous; Katarina Vucic; Iva Kirac; Masa Filipovic; Sarah E Harris; Ian J Deary; Richard Houlston; Ian P Tomlinson; Harry Campbell; Evropi Theodoratou; Malcolm G Dunlop Journal: BMC Med Date: 2018-08-14 Impact factor: 8.775