Masahiro Okada1, Naohito Hato1, Shin-Ya Nishio2, Ryosuke Kitoh2, Kaoru Ogawa3, Sho Kanzaki3, Michihiko Sone4, Satoshi Fukuda5, Akira Hara6, Tetsuo Ikezono7, Kotaro Ishikawa8, Satoshi Iwasaki9, Kimitaka Kaga10, Seiji Kakehata11, Atsushi Matsubara12, Tatsuo Matsunaga10, Takaaki Murata13, Yasushi Naito14, Takashi Nakagawa15, Kazunori Nishizaki16, Yoshihiro Noguchi2, Hajime Sano17, Hiroaki Sato18, Mikio Suzuki19, Hideo Shojaku20, Haruo Takahashi21, Hidehiko Takeda22, Tetsuya Tono23, Hiroshi Yamashita24, Tatsuya Yamasoba25, Shin-Ichi Usami2. 1. a Department of Otolaryngology , Ehime University School of Medicine , Toon , Japan. 2. b Department of Otorhinolaryngology , Shinshu University School of Medicine , Matsumoto , Japan. 3. c Department of Otorhinolaryngology Head and Neck Surgery , Keio University School of Medicine , Tokyo , Japan. 4. d Department of Otorhinolaryngology , Nagoya University, Graduate School of Medicine , Nagoya , Japan. 5. e Department of Otolaryngology-Head and Neck Surgery , Hokkaido University Graduate School of Medicine , Sapporo , Japan. 6. f Department of Otolaryngology, Faculty of Medicine , University of Tsukuba , Tsukuba , Japan. 7. g Department of Otorhinolaryngology , Saitama School of Medicine , Moroyama , Japan. 8. h Department of Otolaryngology, Hospital , National Rehabilitation Center for Persons with Disabilities , Tokorozawa , Japan. 9. i Department of Otolaryngology , International University of Health and Welfare, Mita Hospital , Tokyo , Japan. 10. j Division of Hearing and Balance Research , National Institute of Sensory Organs, National Hospital Organization Tokyo Medical Center , Tokyo , Japan. 11. k Department of Otorhinolaryngology , Yamagata University School of Medicine , Yamagata , Japan. 12. l Department of Otorhinolaryngology , Hirosaki University Graduate School of Medicine , Hirosaki , Japan. 13. m Department of Otolaryngology , Gunma University Graduate School of Medicine , Maebashi , Japan. 14. n Department of Otolaryngology , Kobe City Medical Center General Hospital , Kobe , Japan. 15. o Department of Otorhinolaryngology , Kyushu University Graduate School of Medical Sciences , Fukuoka , Japan. 16. p Department of Otolaryngology-Head and Neck Surgery , Okayama University Graduate School of Medicine, Dentistry and Pharmacy , Okayama , Japan. 17. q Department of Otolaryngology , Kitasato University School of Medicine , Sagamihara , Japan. 18. r Department of Otorhinolaryngology , Iwate Medical University , Morioka , Japan. 19. s Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Medicine , University of the Ryukyus , Nishihara , Japan. 20. t Department of Otorhinolaryngology, Head and Neck Surgery , University of Toyama , Toyama , Japan. 21. u Department of Otolaryngology , Nagasaki University Faculty of Medicine , Nagasaki , Japan. 22. v Department of Otolaryngology , Okinaka Memorial Institute for Medical Research, Toranomon Hospital , Tokyo , Japan. 23. w Department of Otolaryngology, Faculty of Medicine , University of Miyazaki , Miyazaki , Japan. 24. x Department of Otolaryngology , Yamaguchi University Graduate School of Medicine , Ube , Japan. 25. y Department of Otolaryngology, Faculty of Medicine , University of Tokyo , Tokyo , Japan.
Abstract
OBJECTIVE: To investigate the hearing prognosis of idiopathic sudden sensorineural hearing loss (SSNHL) treated with different initial therapies. METHODS: Subjects consisted of patients diagnosed with idiopathic SSNHL within 7 days from onset and showing severe hearing loss (≥60 dB), who were registered in a Japanese multicenter database between April 2014 and March 2016. Subjects were divided into four groups according to initial therapy: (1) steroids, (2) steroids + Prostaglandins (PGs), (3) intratympanic steroids (ITS), and (4) no steroids. Hearing outcomes were compared among the groups. RESULTS: In total, 1305 patients were enrolled. The final hearing level and hearing gain of patients treated with steroids + PGs were significantly higher than those of patients treated with steroids alone or no steroids. The ratio of good prognosis (complete recovery or marked improvement) in patients treated with steroids + PGs was higher than that in patients treated with steroids alone or no steroids. There was no difference in the prognosis of patients treated with steroids alone or no steroids. CONCLUSION: A large number of patients with idiopathic SSNHL were registered in a multicenter database. PG use in combination with steroid administration was associated with a good hearing prognosis in patients with severe hearing loss.
OBJECTIVE: To investigate the hearing prognosis of idiopathic sudden sensorineural hearing loss (SSNHL) treated with different initial therapies. METHODS: Subjects consisted of patients diagnosed with idiopathic SSNHL within 7 days from onset and showing severe hearing loss (≥60 dB), who were registered in a Japanese multicenter database between April 2014 and March 2016. Subjects were divided into four groups according to initial therapy: (1) steroids, (2) steroids + Prostaglandins (PGs), (3) intratympanic steroids (ITS), and (4) no steroids. Hearing outcomes were compared among the groups. RESULTS: In total, 1305 patients were enrolled. The final hearing level and hearing gain of patients treated with steroids + PGs were significantly higher than those of patients treated with steroids alone or no steroids. The ratio of good prognosis (complete recovery or marked improvement) in patients treated with steroids + PGs was higher than that in patients treated with steroids alone or no steroids. There was no difference in the prognosis of patients treated with steroids alone or no steroids. CONCLUSION: A large number of patients with idiopathic SSNHL were registered in a multicenter database. PG use in combination with steroid administration was associated with a good hearing prognosis in patients with severe hearing loss.
Authors: Kelsie J Grant; Aravindakshan Parthasarathy; Viacheslav Vasilkov; Benjamin Caswell-Midwinter; Maria E Freitas; Victor de Gruttola; Daniel B Polley; M Charles Liberman; Stéphane F Maison Journal: Sci Rep Date: 2022-06-23 Impact factor: 4.996
Authors: Masahiro Okada; Aravindakshan Parthasarathy; D Bradley Welling; M Charles Liberman; Stéphane F Maison Journal: Ear Hear Date: 2021 July/Aug Impact factor: 3.562