Literature DB >> 2835227

Expression of the G6PD locus on the human X chromosome is associated with demethylation of three CpG islands within 100 kb of DNA.

D Toniolo1, G Martini, B R Migeon, R Dono.   

Abstract

We have previously reported that expression of the G6PD locus is correlated with the methylation status of two islands of CpG dinucleotides which are 3' to the locus and in the 5' region of two adjacent genes of unknown function, P3 and GdX. We have now examined the methylation of a third CpG island in the promoter region of the G6PD gene itself in DNA from males, females and reactivants that express G6PD on the inactive X chromosome. Our results show that expression of the G6PD gene is associated with concordant demethylation of all three CpG islands in this 100-kb region of DNA.

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Year:  1988        PMID： 2835227      PMCID： PMC454334          DOI： 10.1002/j.1460-2075.1988.tb02827.x

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  20 in total

Review 1.  X-chromosome inactivation and developmental patterns in mammals.

Authors:  M F Lyon
Journal:  Biol Rev Camb Philos Soc       Date:  1972-01

2.  Studies of X chromosome DNA methylation in normal human cells.

Authors:  S F Wolf; B R Migeon
Journal:  Nature       Date:  1982-02-25       Impact factor: 49.962

Review 3.  Mammalian X-chromosome inactivation.

Authors:  S M Gartler; A D Riggs
Journal:  Annu Rev Genet       Date:  1983       Impact factor: 16.830

4.  Differential methylation of hypoxanthine phosphoribosyltransferase genes on active and inactive human X chromosomes.

Authors:  P H Yen; P Patel; A C Chinault; T Mohandas; L J Shapiro
Journal:  Proc Natl Acad Sci U S A       Date:  1984-03       Impact factor: 11.205

5.  Differences in the DNA of the inactive X chromosomes of fetal and extraembryonic tissues of mice.

Authors:  P G Kratzer; V M Chapman; H Lambert; R E Evans; R M Liskay
Journal:  Cell       Date:  1983-05       Impact factor: 41.582

6.  Derepression with decreased expression of the G6PD locus on the inactive X chromosome in normal human cells.

Authors:  B R Migeon; S F Wolf; C Mareni; J Axelman
Journal:  Cell       Date:  1982-06       Impact factor: 41.582

7.  Methylation of the hypoxanthine phosphoribosyltransferase locus on the human X chromosome: implications for X-chromosome inactivation.

Authors:  S F Wolf; D J Jolly; K D Lunnen; T Friedmann; B R Migeon
Journal:  Proc Natl Acad Sci U S A       Date:  1984-05       Impact factor: 11.205

8.  Transformation with DNA from 5-azacytidine-reactivated X chromosomes.

Authors:  L Venolia; S M Gartler; E R Wassman; P Yen; T Mohandas; L J Shapiro
Journal:  Proc Natl Acad Sci U S A       Date:  1982-04       Impact factor: 11.205

9.  Comparison of factor IX methylation on human active and inactive X chromosomes: implications for X inactivation and transcription of tissue-specific genes.

Authors:  C R Cullen; P Hubberman; D C Kaslow; B R Migeon
Journal:  EMBO J       Date:  1986-09       Impact factor: 11.598

10.  Specific methylation pattern at the 3' end of the human housekeeping gene for glucose 6-phosphate dehydrogenase.

Authors:  D Toniolo; M D'Urso; G Martini; M Persico; V Tufano; G Battistuzzi; L Luzzatto
Journal:  EMBO J       Date:  1984-09       Impact factor: 11.598
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  28 in total

1.  Polymerase chain reaction-aided genomic sequencing of an X chromosome-linked CpG island: methylation patterns suggest clonal inheritance, CpG site autonomy, and an explanation of activity state stability.

Authors:  G P Pfeifer; S D Steigerwald; R S Hansen; S M Gartler; A D Riggs
Journal:  Proc Natl Acad Sci U S A       Date:  1990-11       Impact factor: 11.205

2.  Methylation status of CpG-rich islands on active and inactive mouse X chromosomes.

Authors:  D P Norris; N Brockdorff; S Rastan
Journal:  Mamm Genome       Date:  1991       Impact factor: 2.957

3.  Characterization of the level, target sites and inheritance of cytosine methylation in tomato nuclear DNA.

Authors:  R Messeguer; M W Ganal; J C Steffens; S D Tanksley
Journal:  Plant Mol Biol       Date:  1991-05       Impact factor: 4.076

4.  De novo methylation of the MyoD1 CpG island during the establishment of immortal cell lines.

Authors:  P A Jones; M J Wolkowicz; W M Rideout; F A Gonzales; C M Marziasz; G A Coetzee; S J Tapscott
Journal:  Proc Natl Acad Sci U S A       Date:  1990-08       Impact factor: 11.205

5.  Full-length cDNA sequence of the X-linked HPRT gene of an Australian marsupial, the wallaroo (Macropus robustus).

Authors:  J Conaty; A A Piper
Journal:  Mamm Genome       Date:  1996-01       Impact factor: 2.957

6.  Analysis of methylation of a human X located gene which escapes X inactivation.

Authors:  C Mondello; P J Goodfellow; P N Goodfellow
Journal:  Nucleic Acids Res       Date:  1988-07-25       Impact factor: 16.971

7.  Methylation status of genes flanking the fragile site in males with the fragile-X syndrome: a test of the imprinting hypothesis.

Authors:  M M Khalifa; A L Reiss; B R Migeon
Journal:  Am J Hum Genet       Date:  1990-04       Impact factor: 11.025

8.  Chromatin loop structure of the human X chromosome: relevance to X inactivation and CpG clusters.

Authors:  A H Beggs; B R Migeon
Journal:  Mol Cell Biol       Date:  1989-06       Impact factor: 4.272

9.  CpG islands of the X chromosome are gene associated.

Authors:  M Alcalay; D Toniolo
Journal:  Nucleic Acids Res       Date:  1988-10-25       Impact factor: 16.971

10.  Hemimethylation and hypersensitivity are early events in transcriptional reactivation of human inactive X-linked genes in a hamster x human somatic cell hybrid.

Authors:  T Sasaki; R S Hansen; S M Gartler
Journal:  Mol Cell Biol       Date:  1992-09       Impact factor: 4.272
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