Sandra Andorf1, Magnus P Borres2, Whitney Block1, Dana Tupa1, Jennifer B Bollyky3, Vanitha Sampath1, Arnon Elizur1, Jonas Lidholm4, Joseph E Jones5, Stephen J Galli6, Rebecca S Chinthrajah1, Kari C Nadeau7. 1. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University, Stanford, Calif; Sean N. Parker Center for Allergy and Asthma Research, Stanford University, Stanford, Calif. 2. Thermo Fisher Scientific, Immunodiagnostics, Uppsala, Sweden; Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. 3. Division of General Medicine, Department of Medicine, Stanford University, Stanford, Calif. 4. Thermo Fisher Scientific, Immunodiagnostics, Uppsala, Sweden. 5. Thermo Fisher Scientific, Immunodiagnostics, Kalamazoo, Mich. 6. Sean N. Parker Center for Allergy and Asthma Research, Stanford University, Stanford, Calif; Departments of Pathology and of Microbiology and Immunology, Stanford University School of Medicine, Stanford, Calif. 7. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University, Stanford, Calif; Sean N. Parker Center for Allergy and Asthma Research, Stanford University, Stanford, Calif. Electronic address: knadeau@stanford.edu.
Abstract
BACKGROUND: Thirty percent of children with food allergies have multiple simultaneous allergies; however, the features of these multiple allergies are not well characterized serologically or clinically. OBJECTIVE: We comprehensively evaluated 60 multifood-allergic patients by measuring serum IgE to key allergen components, evaluating clinical histories and medication use, performing skin tests, and conducting double-blind, placebo-controlled food challenges (DBPCFCs). METHODS: Sixty participants with multiple food allergies were characterized by clinical history, DBPCFCs, total IgE, specific IgE, and component-resolved diagnostics (IgE and IgG4) data. The food allergens tested were almond, egg, milk, sesame, peanut, pecan, walnut, hazelnut, cashew, pistachio, soy, and wheat. RESULTS: Our data demonstrate that of the reactions observed during a graded DBPCFC, gastrointestinal reactions occurred more often in boys than in girls, as well as in individuals with high levels of IgE to 2S albumins from cashew, walnut, and hazelnut. Certain food allergies often occurred concomitantly in individuals (ie, cashew/pistachio and walnut/pecan/hazelnut). IgE testing to components further corroborated serological relationships between and among these clustered food allergies. CONCLUSIONS: Associations of certain food allergies were shown by DBPCFC outcomes as well as by correlations in IgE reactivity to structurally related food allergen components. Each of these criteria independently demonstrated a significant association between allergies to cashew and pistachio, as well as among allergies to walnut, pecan, and hazelnut.
BACKGROUND: Thirty percent of children with food allergies have multiple simultaneous allergies; however, the features of these multiple allergies are not well characterized serologically or clinically. OBJECTIVE: We comprehensively evaluated 60 multifood-allergic patients by measuring serum IgE to key allergen components, evaluating clinical histories and medication use, performing skin tests, and conducting double-blind, placebo-controlled food challenges (DBPCFCs). METHODS: Sixty participants with multiple food allergies were characterized by clinical history, DBPCFCs, total IgE, specific IgE, and component-resolved diagnostics (IgE and IgG4) data. The food allergens tested were almond, egg, milk, sesame, peanut, pecan, walnut, hazelnut, cashew, pistachio, soy, and wheat. RESULTS: Our data demonstrate that of the reactions observed during a graded DBPCFC, gastrointestinal reactions occurred more often in boys than in girls, as well as in individuals with high levels of IgE to 2S albumins from cashew, walnut, and hazelnut. Certain food allergies often occurred concomitantly in individuals (ie, cashew/pistachio and walnut/pecan/hazelnut). IgE testing to components further corroborated serological relationships between and among these clustered food allergies. CONCLUSIONS: Associations of certain food allergies were shown by DBPCFC outcomes as well as by correlations in IgE reactivity to structurally related food allergen components. Each of these criteria independently demonstrated a significant association between allergies to cashew and pistachio, as well as among allergies to walnut, pecan, and hazelnut.
Authors: S A Bock; H A Sampson; F M Atkins; R S Zeiger; S Lehrer; M Sachs; R K Bush; D D Metcalfe Journal: J Allergy Clin Immunol Date: 1988-12 Impact factor: 10.793
Authors: K Beyer; L Grabenhenrich; M Härtl; A Beder; B Kalb; M Ziegert; A Finger; N Harandi; R Schlags; M Gappa; L Puzzo; H Röblitz; M Millner-Uhlemann; S Büsing; H Ott; L Lange; B Niggemann Journal: Allergy Date: 2014-11-30 Impact factor: 13.146
Authors: Yamini V Virkud; Yih-Chieh Chen; Elisabeth S Stieb; Alexandra R Alejos; Nicholas Renton; Wayne G Shreffler; Paul E Hesterberg Journal: J Allergy Clin Immunol Pract Date: 2019-04-08
Authors: Weiqi Wang; Shu-Chen Lyu; Xuhuai Ji; Sheena Gupta; Monali Manohar; Gopal K R Dhondalay; Sharon Chinthrajah; Sandra Andorf; Scott D Boyd; Robert Tibshirani; Stephen J Galli; Kari C Nadeau; Holden T Maecker Journal: Clin Immunol Date: 2020-08-09 Impact factor: 3.969
Authors: Monali Manohar; Diane Dunham; Sheena Gupta; Zheng Yan; Wenming Zhang; Samantha Minnicozzi; Matthew Kirkey; Bryan Bunning; Roshni Roy Chowdhury; Stephen J Galli; Scott D Boyd; Laurie Elizabeth Kost; R Sharon Chinthrajah; Manisha Desai; Hans C Oettgen; Holden T Maecker; Wong Yu; Rosemarie H DeKruyff; Sandra Andorf; Kari C Nadeau Journal: Allergy Date: 2021-05-29 Impact factor: 14.710
Authors: Lucy Duan; Alper Celik; Jennifer A Hoang; Klara Schmidthaler; Delvin So; Xiaojun Yin; Christina M Ditlof; Marta Ponce; Julia E M Upton; Jean-Soo Lee; Lisa Hung; Heimo Breiteneder; Chiara Palladino; Adelle R Atkinson; Vy H D Kim; Alireza Berenjy; Maria Asper; David Hummel; Samantha Wong; Mara Alexanian-Farr; Ahuva Magder; Sharon R Chinthrajah; Kaori Mukai; Mindy Tsai; Kari Nadeau; Stephen J Galli; Arun K Ramani; Zsolt Szepfalusi; Thomas Eiwegger Journal: Allergy Date: 2020-12-29 Impact factor: 14.710
Authors: Stephen C Dreskin; Stef J Koppelman; Sandra Andorf; Kari C Nadeau; Anjeli Kalra; Werner Braun; Surendra S Negi; Xueni Chen; Catherine H Schein Journal: J Allergy Clin Immunol Date: 2020-11-18 Impact factor: 10.793