J A van der Voet1, J Runhaar2, P van der Plas3, D Vroegindeweij4, E H Oei5, S M A Bierma-Zeinstra6. 1. Department of Radiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands; Department of Radiology, Maasstad Hospital, Rotterdam, The Netherlands. Electronic address: j.a.vandervoet@erasmusmc.nl. 2. Department of General Practice, Erasmus MC, University Medical Center, Rotterdam, The Netherlands. Electronic address: j.runhaar@erasmusmc.nl. 3. Department of Radiology, Franciscus Gasthuis and Vlietland Hospital, Rotterdam, The Netherlands. Electronic address: pvdplas@gmail.com. 4. Department of Radiology, Maasstad Hospital, Rotterdam, The Netherlands. Electronic address: VroegindeweijD@maasstadziekenhuis.nl. 5. Department of Radiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands. Electronic address: e.oei@erasmusmc.nl. 6. Department of General Practice, Erasmus MC, University Medical Center, Rotterdam, The Netherlands; Department of Orthopaedics, Erasmus MC, University Medical Center, Rotterdam, The Netherlands. Electronic address: s.bierma-zeinstra@erasmusmc.nl.
Abstract
OBJECTIVE: To investigate the association between baseline meniscal extrusion and the incidence of knee osteoarthritis (KOA) after 30 months in a high-risk population of overweight and obese women, free of clinical and radiological KOA at baseline. METHODS: 407 middle-aged overweight women (body mass index - BMI ≥ 27 kg/m2) were evaluated at baseline and after 30 months of follow-up. Meniscal extrusion was defined as grade ≥2 on MRI according to MRI Osteoarthritis Knee Score (MOAKS). The primary outcome measure was KOA after 30 months follow-up, defined using the following criteria: either incidence of radiographic KOA (Kellgren & Lawrence grade 2 or higher), or clinical osteoarthritis (OA) according to the American College of Radiology (ACR) criteria, or medial or lateral joint space narrowing (JSN) of ≥1.0 mm. Using generalized estimating equations (GEE), we determined the association between knees with and without meniscal extrusion and both outcomes, corrected for the baseline differences. RESULTS: 640 knees were available at baseline of which 24% (153) had meniscal extrusion. There was a significantly higher incidence of KOA according to the primary outcome measure in women with meniscal extrusion compared to those without extrusion (28.8%, odds ratio - OR 2.39, 95% CI 1.53, 3.73). A significantly higher incidence was found for the development of radiographic KOA (12.4%, OR 2.61, 95% CI 1.11, 6.13) and medial JSN (11.8%, OR 3.19, 95% CI 1.59, 6.41). Meniscal extrusion was not significantly associated with clinical KOA and lateral JSN. CONCLUSION: Meniscal extrusion was associated with a significantly higher incidence of KOA, providing an interesting target for early detection of individuals at risk for developing KOA.
OBJECTIVE: To investigate the association between baseline meniscal extrusion and the incidence of knee osteoarthritis (KOA) after 30 months in a high-risk population of overweight and obesewomen, free of clinical and radiological KOA at baseline. METHODS: 407 middle-aged overweight women (body mass index - BMI ≥ 27 kg/m2) were evaluated at baseline and after 30 months of follow-up. Meniscal extrusion was defined as grade ≥2 on MRI according to MRI Osteoarthritis Knee Score (MOAKS). The primary outcome measure was KOA after 30 months follow-up, defined using the following criteria: either incidence of radiographic KOA (Kellgren & Lawrence grade 2 or higher), or clinical osteoarthritis (OA) according to the American College of Radiology (ACR) criteria, or medial or lateral joint space narrowing (JSN) of ≥1.0 mm. Using generalized estimating equations (GEE), we determined the association between knees with and without meniscal extrusion and both outcomes, corrected for the baseline differences. RESULTS: 640 knees were available at baseline of which 24% (153) had meniscal extrusion. There was a significantly higher incidence of KOA according to the primary outcome measure in women with meniscal extrusion compared to those without extrusion (28.8%, odds ratio - OR 2.39, 95% CI 1.53, 3.73). A significantly higher incidence was found for the development of radiographic KOA (12.4%, OR 2.61, 95% CI 1.11, 6.13) and medial JSN (11.8%, OR 3.19, 95% CI 1.59, 6.41). Meniscal extrusion was not significantly associated with clinical KOA and lateral JSN. CONCLUSION: Meniscal extrusion was associated with a significantly higher incidence of KOA, providing an interesting target for early detection of individuals at risk for developing KOA.
Authors: Lianzhi Chen; Jessica Jun Yi Zheng; Guangyi Li; Jun Yuan; Jay R Ebert; Hengyuan Li; John Papadimitriou; Qingwen Wang; David Wood; Christopher W Jones; Minghao Zheng Journal: J Orthop Translat Date: 2020-05-15 Impact factor: 5.191
Authors: Lizette Utomo; Susanne M Eijgenraam; Duncan E Meuffels; Sita M A Bierma-Zeinstra; Yvonne M Bastiaansen-Jenniskens; Gerjo J V M van Osch Journal: J Orthop Res Date: 2018-04-25 Impact factor: 3.494
Authors: Dawei Xu; Jan van der Voet; Nils M Hansson; Stefan Klein; Edwin H G Oei; Femke Wagner; Sebastia M A Bierma-Zeinstra; Jos Runhaar Journal: Rheumatology (Oxford) Date: 2021-03-02 Impact factor: 7.580