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Literature DB >> 28344725

Sensitive and predictable separation of microfluidic droplets by size using in-line passive filter.

Ruihua Ding¹, W Lloyd Ung², John A Heyman, David A Weitz².

Abstract

Active manipulation of droplets is crucial in droplet microfluidics. However, droplet polydispersity decreases the accuracy of active manipulation. We develop a microfluidic "droplet filter" that accurately separates droplets by size. The droplet filter has a sharp size cutoff and is capable of distinguishing droplets differing in volume by 20%. A simple model explains the behavior of the droplets as they pass through the filter. We show application of the filter in improving dielectric sorting efficiency.

Year: 2017 PMID： 28344725 PMCID： PMC5336469 DOI： 10.1063/1.4976723

Source DB: PubMed Journal: Biomicrofluidics ISSN： 1932-1058 Impact factor: 2.800

18 in total

1. Continuous particle separation through deterministic lateral displacement.

Authors: Lotien Richard Huang; Edward C Cox; Robert H Austin; James C Sturm
Journal: Science Date: 2004-05-14 Impact factor: 47.728

2. High-resolution dose-response screening using droplet-based microfluidics.

Authors: Oliver J Miller; Abdeslam El Harrak; Thomas Mangeat; Jean-Christophe Baret; Lucas Frenz; Bachir El Debs; Estelle Mayot; Michael L Samuels; Eamonn K Rooney; Pierre Dieu; Martin Galvan; Darren R Link; Andrew D Griffiths
Journal: Proc Natl Acad Sci U S A Date: 2011-12-27 Impact factor: 11.205

3. Force driven separation of drops by deterministic lateral displacement.

Authors: Timothy Bowman; Joelle Frechette; German Drazer
Journal: Lab Chip Date: 2012-06-14 Impact factor: 6.799

4. High-throughput injection with microfluidics using picoinjectors.

Authors: Adam R Abate; Tony Hung; Pascaline Mary; Jeremy J Agresti; David A Weitz
Journal: Proc Natl Acad Sci U S A Date: 2010-10-20 Impact factor: 11.205

5. Droplet fusion by alternating current (AC) field electrocoalescence in microchannels.

Authors: Max Chabert; Kevin D Dorfman; Jean-Louis Viovy
Journal: Electrophoresis Date: 2005-10 Impact factor: 3.535

6. Dynamic modulation of chemical concentration in an aqueous droplet.

Authors: Gavin D M Jeffries; Jason S Kuo; Daniel T Chiu
Journal: Angew Chem Int Ed Engl Date: 2007 Impact factor: 15.336

7. Droplet size based separation by deterministic lateral displacement-separating droplets by cell--induced shrinking.

Authors: Haakan N Joensson; Mathias Uhlén; Helene Andersson Svahn
Journal: Lab Chip Date: 2011-02-14 Impact factor: 6.799

8. Single-cell analysis and sorting using droplet-based microfluidics.

Authors: Linas Mazutis; John Gilbert; W Lloyd Ung; David A Weitz; Andrew D Griffiths; John A Heyman
Journal: Nat Protoc Date: 2013-04-04 Impact factor: 13.491

9. Microdroplet-based PCR enrichment for large-scale targeted sequencing.

Authors: Ryan Tewhey; Jason B Warner; Masakazu Nakano; Brian Libby; Martina Medkova; Patricia H David; Steve K Kotsopoulos; Michael L Samuels; J Brian Hutchison; Jonathan W Larson; Eric J Topol; Michael P Weiner; Olivier Harismendy; Jeff Olson; Darren R Link; Kelly A Frazer
Journal: Nat Biotechnol Date: 2009-11-01 Impact factor: 54.908

Sensitive and predictable separation of microfluidic droplets by size using in-line passive filter.

1. Continuous particle separation through deterministic lateral displacement.

2. High-resolution dose-response screening using droplet-based microfluidics.

3. Force driven separation of drops by deterministic lateral displacement.

4. High-throughput injection with microfluidics using picoinjectors.

5. Droplet fusion by alternating current (AC) field electrocoalescence in microchannels.

6. Dynamic modulation of chemical concentration in an aqueous droplet.

7. Droplet size based separation by deterministic lateral displacement-separating droplets by cell--induced shrinking.

8. Single-cell analysis and sorting using droplet-based microfluidics.

9. Microdroplet-based PCR enrichment for large-scale targeted sequencing.

10. A mix-and-read drop-based in vitro two-hybrid method for screening high-affinity peptide binders.

1. Rapid isolation of antigen-specific B-cells using droplet microfluidics.

2. Size-Dependent and Property-Independent Passive Microdroplet Sorting by Droplet Transfer on Dot Rails.

3. One-Pot Assembly of Complex Giant Unilamellar Vesicle-Based Synthetic Cells.

Review 4. Lab-on-a-Chip Technologies for the Single Cell Level: Separation, Analysis, and Diagnostics.

5. FIDELITY: A quality control system for droplet microfluidics.