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Literature DB >> 20962271

High-throughput injection with microfluidics using picoinjectors.

Adam R Abate¹, Tony Hung, Pascaline Mary, Jeremy J Agresti, David A Weitz.

Abstract

Adding reagents to drops is one of the most important functions in droplet-based microfluidic systems; however, a robust technique to accomplish this does not exist. Here, we introduce the picoinjector, a robust device to add controlled volumes of reagent using electro-microfluidics at kilohertz rates. It can also perform multiple injections for serial and combinatorial additions.

Mesh：

Substances：
Indicators and Reagents

Year: 2010 PMID： 20962271 PMCID： PMC2984161 DOI： 10.1073/pnas.1006888107

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

18 in total

1. Dynamic pattern formation in a vesicle-generating microfluidic device.

Authors: T Thorsen; R W Roberts; F H Arnold; S R Quake
Journal: Phys Rev Lett Date: 2001-04-30 Impact factor: 9.161

2. Measurement of activity of single molecules of beta-D-galactosidase.

Authors: B ROTMAN
Journal: Proc Natl Acad Sci U S A Date: 1961-12-15 Impact factor: 11.205

3. On-chip titration of an anticoagulant argatroban and determination of the clotting time within whole blood or plasma using a plug-based microfluidic system.

Authors: Helen Song; Hung-Wing Li; Matthew S Munson; Thuong G Van Ha; Rustem F Ismagilov
Journal: Anal Chem Date: 2006-07-15 Impact factor: 6.986

Review 4. Reactions in droplets in microfluidic channels.

Authors: Helen Song; Delai L Chen; Rustem F Ismagilov
Journal: Angew Chem Int Ed Engl Date: 2006-11-13 Impact factor: 15.336

5. Hydrodynamic resistance of single confined moving drops in rectangular microchannels.

Authors: Siva A Vanapalli; Arun G Banpurkar; Dirk van den Ende; Michel H G Duits; Frieder Mugele
Journal: Lab Chip Date: 2008-12-19 Impact factor: 6.799

6. Rapid Prototyping of Microfluidic Systems in Poly(dimethylsiloxane).

Authors: D C Duffy; J C McDonald; O J Schueller; G M Whitesides
Journal: Anal Chem Date: 1998-12-01 Impact factor: 6.986

7. Biocompatible surfactants for water-in-fluorocarbon emulsions.

Authors: C Holtze; A C Rowat; J J Agresti; J B Hutchison; F E Angilè; C H J Schmitz; S Köster; H Duan; K J Humphry; R A Scanga; J S Johnson; D Pisignano; D A Weitz
Journal: Lab Chip Date: 2008-09-02 Impact factor: 6.799

8. Droplet-based microfluidic platforms for the encapsulation and screening of Mammalian cells and multicellular organisms.

Authors: Jenifer Clausell-Tormos; Diana Lieber; Jean-Christophe Baret; Abdeslam El-Harrak; Oliver J Miller; Lucas Frenz; Joshua Blouwolff; Katherine J Humphry; Sarah Köster; Honey Duan; Christian Holtze; David A Weitz; Andrew D Griffiths; Christoph A Merten
Journal: Chem Biol Date: 2008-05

9. Microfluidic high-throughput encapsulation and hydrodynamic self-sorting of single cells.

Authors: Max Chabert; Jean-Louis Viovy
Journal: Proc Natl Acad Sci U S A Date: 2008-03-03 Impact factor: 11.205

10. Microdroplet-based PCR enrichment for large-scale targeted sequencing.

Authors: Ryan Tewhey; Jason B Warner; Masakazu Nakano; Brian Libby; Martina Medkova; Patricia H David; Steve K Kotsopoulos; Michael L Samuels; J Brian Hutchison; Jonathan W Larson; Eric J Topol; Michael P Weiner; Olivier Harismendy; Jeff Olson; Darren R Link; Kelly A Frazer
Journal: Nat Biotechnol Date: 2009-11-01 Impact factor: 54.908

109 in total

High-throughput injection with microfluidics using picoinjectors.

1. Dynamic pattern formation in a vesicle-generating microfluidic device.

2. Measurement of activity of single molecules of beta-D-galactosidase.

3. On-chip titration of an anticoagulant argatroban and determination of the clotting time within whole blood or plasma using a plug-based microfluidic system.

Review 4. Reactions in droplets in microfluidic channels.

5. Hydrodynamic resistance of single confined moving drops in rectangular microchannels.

6. Rapid Prototyping of Microfluidic Systems in Poly(dimethylsiloxane).

7. Biocompatible surfactants for water-in-fluorocarbon emulsions.

8. Droplet-based microfluidic platforms for the encapsulation and screening of Mammalian cells and multicellular organisms.

9. Microfluidic high-throughput encapsulation and hydrodynamic self-sorting of single cells.

10. Microdroplet-based PCR enrichment for large-scale targeted sequencing.

1. Emerging technologies in medical applications of minimum volume vitrification.

2. DNA-library assembly programmed by on-demand nano-liter droplets from a custom microfluidic chip.

3. Droplet CAR-Wash: continuous picoliter-scale immunocapture and washing.

4. Droplet Incubation and Splitting in Open Microfluidic Channels.

5. Controlling droplet incubation using close-packed plug flow.

6. Syringe-vacuum microfluidics: A portable technique to create monodisperse emulsions.

7. Electrocoalescence based serial dilution of microfluidic droplets.

8. Droplet-based microfluidic washing module for magnetic particle-based assays.

9. Coalescing drops in microfluidic parking networks: A multifunctional platform for drop-based microfluidics.

10. Evaporation-based microfluidic production of oil-free cell-containing hydrogel particles.