| Literature DB >> 28343740 |
Nita L Seibel1, Katherine Janeway2, Carl E Allen3, Susan N Chi2, Yoon-Jae Cho4, Julia L Glade Bender5, AeRang Kim6, Theodore W Laetsch7, Meredith S Irwin8, Naoko Takebe9, James V Tricoli10, Donald Williams Parsons11.
Abstract
With the use of high-throughput molecular profiling technologies, precision medicine trials are ongoing for adults with cancer. Similarly, there is an interest in how these techniques can be applied to tumors in children and adolescents to expand our understanding of the biology of pediatric cancers and evaluate the clinical implications of genomic testing for these patients. This article reviews the early studies in pediatric oncology showing the feasibility of this approach, describe the future plans to evaluate the clinical implications in a multicenter clinical trial and identify the challenges of applying genomics in this patient population. Published by Elsevier Inc.Entities:
Keywords: Adolescent and young adult cancer; Genomic profiling; Next-generation sequencing; Pediatric tumors; RNA sequencing; Whole-exome sequencing
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Year: 2017 PMID： 28343740 DOI： 10.1016/j.currproblcancer.2017.01.002
Source DB: PubMed Journal: Curr Probl Cancer ISSN： 0147-0272 Impact factor: 3.187