Kelly Haas1, Andrew Martin2, K T Park3. 1. Department of Pediatrics, Division of Gastroenterology, Stanford University School of Medicine, Stanford University, Palo Alto, CA. Electronic address: kbhaas@stanford.edu. 2. Center for Clinical Informatics, Stanford University School of Medicine, Stanford University, Palo Alto, CA. 3. Department of Pediatrics, Division of Gastroenterology, Stanford University School of Medicine, Stanford University, Palo Alto, CA.
Abstract
OBJECTIVE: To determine the impact of the Text Message Educational Automated Compliance Help (TEACH) text message intervention as a pragmatic approach for patient engagement among adolescents with celiac disease (CD) as measured by gluten-free diet (GFD) adherence, patient activation, and quality of life (QOL). STUDY DESIGN: Randomized controlled trial with patient recruitment at a pediatric, university-based hospital and through social media; 61 participants ages 12-24 years with CD diagnosed at least 1 year were enrolled. The TEACH intervention cohort received 45 unique text messages over a 3-month study period while the control group received standard of care treatment. Primary outcome measures included objective markers of GFD adherence included serum tissue transglutaminase IgA and deamidated gliadin peptide IgA levels. Secondary patient-reported outcomes collected via online survey included the Celiac Dietary Adherence Test, National Institutes of Health (NIH) Patient-Reported Outcomes Measurement Information System (PROMIS) Global Short Form measure of QOL, Celiac Symptom Index, and Patient Activation Measure. All measures were assessed at enrollment and after the 3-month study period. Statistical analysis performed using the 2-tailed paired Student t test. RESULTS: Among the TEACH intervention group, there was significant improvement comparing enrollment scores with 3-month follow-up scores in patient activation (Patient Activation Measure score 63.1 vs 72.5, P?=?.01) and QOL (NIH PROMIS Global Mental Health 50.8 vs 53.3, P?=?.01 and NIH PROMIS Global Physical Health 50.8 vs 57.7, P?=?.03). There was no statistically significant difference in patient-reported or objectively measured GFD adherence. CONCLUSIONS:TEACH is an effective intervention among patients with CD to improve patient activation and QOL, even among a cohort with GFD adherence at baseline. TRIAL REGISTRATION: ClinicalTrials.gov: NCT02458898.
RCT Entities:
OBJECTIVE: To determine the impact of the Text Message Educational Automated Compliance Help (TEACH) text message intervention as a pragmatic approach for patient engagement among adolescents with celiac disease (CD) as measured by gluten-free diet (GFD) adherence, patient activation, and quality of life (QOL). STUDY DESIGN: Randomized controlled trial with patient recruitment at a pediatric, university-based hospital and through social media; 61 participants ages 12-24 years with CD diagnosed at least 1 year were enrolled. The TEACH intervention cohort received 45 unique text messages over a 3-month study period while the control group received standard of care treatment. Primary outcome measures included objective markers of GFD adherence included serum tissue transglutaminaseIgA and deamidated gliadin peptide IgA levels. Secondary patient-reported outcomes collected via online survey included the Celiac Dietary Adherence Test, National Institutes of Health (NIH) Patient-Reported Outcomes Measurement Information System (PROMIS) Global Short Form measure of QOL, Celiac Symptom Index, and Patient Activation Measure. All measures were assessed at enrollment and after the 3-month study period. Statistical analysis performed using the 2-tailed paired Student t test. RESULTS: Among the TEACH intervention group, there was significant improvement comparing enrollment scores with 3-month follow-up scores in patient activation (Patient Activation Measure score 63.1 vs 72.5, P?=?.01) and QOL (NIH PROMIS Global Mental Health 50.8 vs 53.3, P?=?.01 and NIH PROMIS Global Physical Health 50.8 vs 57.7, P?=?.03). There was no statistically significant difference in patient-reported or objectively measured GFD adherence. CONCLUSIONS: TEACH is an effective intervention among patients with CD to improve patient activation and QOL, even among a cohort with GFD adherence at baseline. TRIAL REGISTRATION: ClinicalTrials.gov: NCT02458898.
Authors: Ivor D Hill; Martha H Dirks; Gregory S Liptak; Richard B Colletti; Alessio Fasano; Stefano Guandalini; Edward J Hoffenberg; Karoly Horvath; Joseph A Murray; Mitchell Pivor; Ernest G Seidman Journal: J Pediatr Gastroenterol Nutr Date: 2005-01 Impact factor: 2.839
Authors: M E McGrady; J L Ryan; A M Gutiérrez-Colina; E M Fredericks; E K Towner; A L H Pai Journal: Child Care Health Dev Date: 2015-08-09 Impact factor: 2.508
Authors: Benjamin Lebwohl; Fredrik Granath; Anders Ekbom; Karin E Smedby; Joseph A Murray; Alfred I Neugut; Peter H R Green; Jonas F Ludvigsson Journal: Ann Intern Med Date: 2013-08-06 Impact factor: 25.391
Authors: Victoria Louise Franklin; Alexandra Greene; Annalu Waller; Stephen Alan Greene; Claudia Pagliari Journal: J Med Internet Res Date: 2008-06-30 Impact factor: 5.428
Authors: Stephanie R Partridge; Kevin McGeechan; Lana Hebden; Kate Balestracci; Annette Ty Wong; Elizabeth Denney-Wilson; Mark F Harris; Philayrath Phongsavan; Adrian Bauman; Margaret Allman-Farinelli Journal: JMIR Mhealth Uhealth Date: 2015-06-15 Impact factor: 4.773
Authors: Brian Suffoletto; Jeffrey Kristan; Tammy Chung; Kwonho Jeong; Anthony Fabio; Peter Monti; Duncan B Clark Journal: PLoS One Date: 2015-11-18 Impact factor: 3.240
Authors: Randi L Wolf; Benjamin Lebwohl; Anne R Lee; Patricia Zybert; Norelle R Reilly; Jennifer Cadenhead; Chelsea Amengual; Peter H R Green Journal: Dig Dis Sci Date: 2018-01-31 Impact factor: 3.199
Authors: Laura E Simon; Adina S Rauchwerger; Uli K Chettipally; Leon Babakhanian; David R Vinson; E Margaret Warton; Mary E Reed; Anupam B Kharbanda; Elyse O Kharbanda; Dustin W Ballard Journal: J Am Med Inform Assoc Date: 2019-11-01 Impact factor: 4.497
Authors: Robert M Cronin; Tim Lucas Dorner; Amol Utrankar; Whitney Allen; Mark Rodeghier; Adetola A Kassim; Gretchen Purcell Jackson; Michael R DeBaun Journal: Pain Med Date: 2019-08-01 Impact factor: 3.750
Authors: Nicole M Alberts; Sherif M Badawy; Jerlym S Porter; Jane S Hankins; Jason Hodges; Jeremie H Estepp; Chinonyelum Nwosu; Hamda Khan; Matthew P Smeltzer; Ramin Homayouni; Sarah Norell; Lisa Klesges Journal: JMIR Mhealth Uhealth Date: 2020-05-08 Impact factor: 4.773
Authors: Sherif M Badawy; Robert M Cronin; Jane Hankins; Lori Crosby; Michael DeBaun; Alexis A Thompson; Nirmish Shah Journal: J Med Internet Res Date: 2018-07-19 Impact factor: 5.428