D R Culqui1, C Linares2, C Ortiz2, R Carmona2, J Díaz2. 1. Autonomous University of Madrid - Ciudad Universitaria de Cantoblanco, 28049 Madrid, Spain; CIBER en Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Evaluation and Intervention Methods Service from Barcelona Public Health Agency, Spain. Electronic address: ext_dculqui@aspb.cat. 2. Department of Epidemiology and Biostatistics, National School of Public Health, Carlos III Institute of Health, Avda. Monforte de Lemos 5, 28029 Madrid, Spain.
Abstract
INTRODUCTION: There are scarce studies of time series that analysed the short-term association between emergency hospital admissions due to Alzheimer's disease (AD) and environmental factors. The objective is to analyse the effect of heat waves, noise and air pollutants on urgent hospital admissions due to AD in Madrid. METHODS: Longitudinal ecological time series study was performed. The dependent variable was the emergency AD hospital admissions occurred in Madrid during the period 2001-2009. Independent variables were: Daily mean concentrations (μg/m3) of air pollutants (PM2.5 and PM10; O3 and NO2); maximum daily temperature (°C) and daily and night noise levels (dB(A)). Relative Risk (RR) for an increment in interquartile range, and Attributable Risk (AR) values were calculated through GLM with Poisson link. RESULTS: Our findings indicated that only PM2.5 concentrations at lag 2 with a RR: 1.38 (95% CI: 1.15-1.65); AR 27.5% (95% CI: 13.0-39.4); and heat wave days at lag 3 with a RR: 1.30 (95% CI: 1.12-1.52); AR 23.1% (95% CI: 10.7-34.2) were associated with AD hospital admissions. CONCLUSION: A reduction in AD patients' exposure levels to PM2.5 and special care of such patients during heat wave periods could result in a decrease in both emergency AD admissions and the related health care costs.
INTRODUCTION: There are scarce studies of time series that analysed the short-term association between emergency hospital admissions due to Alzheimer's disease (AD) and environmental factors. The objective is to analyse the effect of heat waves, noise and air pollutants on urgent hospital admissions due to AD in Madrid. METHODS: Longitudinal ecological time series study was performed. The dependent variable was the emergency AD hospital admissions occurred in Madrid during the period 2001-2009. Independent variables were: Daily mean concentrations (μg/m3) of air pollutants (PM2.5 and PM10; O3 and NO2); maximum daily temperature (°C) and daily and night noise levels (dB(A)). Relative Risk (RR) for an increment in interquartile range, and Attributable Risk (AR) values were calculated through GLM with Poisson link. RESULTS: Our findings indicated that only PM2.5 concentrations at lag 2 with a RR: 1.38 (95% CI: 1.15-1.65); AR 27.5% (95% CI: 13.0-39.4); and heat wave days at lag 3 with a RR: 1.30 (95% CI: 1.12-1.52); AR 23.1% (95% CI: 10.7-34.2) were associated with AD hospital admissions. CONCLUSION: A reduction in ADpatients' exposure levels to PM2.5 and special care of such patients during heat wave periods could result in a decrease in both emergency AD admissions and the related health care costs.
Authors: Stephanie E Cleland; Lauren H Wyatt; Linda Wei; Naman Paul; Marc L Serre; J Jason West; Sarah B Henderson; Ana G Rappold Journal: Environ Health Perspect Date: 2022-06-14 Impact factor: 11.035
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Authors: E Bouza; F Vargas; B Alcázar; T Álvarez; A Asensio; G Cruceta; D Gracia; J Guinea; M A Gil; C Linares; P Muñoz; P Pastor; M L Pedro-Botet; X Querol; J Tovar; I Urrutia; F Villar; E Palomo Journal: Rev Esp Quimioter Date: 2022-03-11 Impact factor: 2.515