Literature DB >> 28340373

Influence of sex on cardiovascular drug responses: role of estrogen.

Abdel A Abdel-Rahman1.   

Abstract

In this review we discuss the sex/estrogen-specific modulation of cardiovascular function and responses to current therapeutics. We discuss how anatomical differences such as a smaller kidney size, and lower glomerular filtration rate in females, reduce the clearance and increase the toxicity of some drugs in females. Other important sex differences include the dampening effect of estrogen on central sympathetic and renin angiotensin systems. Further, we discuss how a shift in myocardial redox status leads to paradoxical transformation of estrogen into a pro-inflammatory hormone. Finally, the review, along with cited recent publications, identify some areas that need further investigation to advance our understanding of the sex differences in cardiovascular disease outcomes to help develop female specific interventions for these anomalies.
Copyright © 2017 Elsevier Ltd. All rights reserved.

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Year:  2017        PMID： 28340373      PMCID： PMC5478467          DOI： 10.1016/j.coph.2017.02.002

Source DB:  PubMed          Journal:  Curr Opin Pharmacol        ISSN： 1471-4892            Impact factor:   5.547


  41 in total

1.  Signaling via GPR30 protects the myocardium from ischemia/reperfusion injury.

Authors:  Brent R Weil; Mariuxi C Manukyan; Jeremy L Herrmann; Yue Wang; Aaron M Abarbanell; Jeffrey A Poynter; Daniel R Meldrum
Journal:  Surgery       Date:  2010-08       Impact factor: 3.982

2.  Estrogen modulation of eNOS activity and its association with caveolin-3 and calmodulin in rat hearts.

Authors:  Xu Wang; Abdel A Abdel-Rahman
Journal:  Am J Physiol Heart Circ Physiol       Date:  2002-06       Impact factor: 4.733

3.  Estrogen receptor ERα plays a major role in ethanol-evoked myocardial oxidative stress and dysfunction in conscious female rats.

Authors:  Fanrong Yao; Abdel A Abdel-Rahman
Journal:  Alcohol       Date:  2015-11-26       Impact factor: 2.405

4.  Estrogen enhancement of baroreflex sensitivity is centrally mediated.

Authors:  M K Mohamed; M M El-Mas; A A Abdel-Rahman
Journal:  Am J Physiol       Date:  1999-04

5.  Effects of Race and Sex on Measured GFR: The Multi-Ethnic Study of Atherosclerosis.

Authors:  Lesley A Inker; Tariq Shafi; Aghogho Okparavero; Hocine Tighiouart; John H Eckfeldt; Ronit Katz; W Craig Johnson; Norma Dermond; Zarqa Tariq; Imene Benayache; Wendy S Post; Josef Coresh; Andrew S Levey; Michael G Shlipak
Journal:  Am J Kidney Dis       Date:  2016-08-20       Impact factor: 8.860

6.  Estrogen modulation of the ethanol-evoked myocardial oxidative stress and dysfunction via DAPK3/Akt/ERK activation in male rats.

Authors:  Mahmoud M El-Mas; Abdel A Abdel-Rahman
Journal:  Toxicol Appl Pharmacol       Date:  2015-06-23       Impact factor: 4.219

7.  Estrogen Receptors α and β Play Major Roles in Ethanol-Evoked Myocardial Oxidative Stress and Dysfunction in Conscious Ovariectomized Rats.

Authors:  Fanrong Yao; Abdel A Abdel-Rahman
Journal:  Alcohol Clin Exp Res       Date:  2016-12-29       Impact factor: 3.455

Review 8.  Effects of hormone replacement therapy on the sympathetic nervous system and blood pressure.

Authors:  J Michael Wyss; Scott H Carlson
Journal:  Curr Hypertens Rep       Date:  2003-06       Impact factor: 5.369

9.  Cardiac-specific catalase overexpression rescues anthrax lethal toxin-induced cardiac contractile dysfunction: role of oxidative stress and autophagy.

Authors:  Machender R Kandadi; Xuejun Yu; Arthur E Frankel; Jun Ren
Journal:  BMC Med       Date:  2012-11-07       Impact factor: 8.775

Review 10.  Diabetes mellitus and oxidative stress-A concise review.

Authors:  Ullah Asmat; Khan Abad; Khan Ismail
Journal:  Saudi Pharm J       Date:  2015-03-21       Impact factor: 4.330
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  9 in total

Review 1.  Sex differences in opioid receptor mediated effects: Role of androgens.

Authors:  Jessica L Sharp; Tallia Pearson; Mark A Smith
Journal:  Neurosci Biobehav Rev       Date:  2022-01-04       Impact factor: 8.989

2.  Estrogen dampens central cannabinoid receptor 1-mediated neuroexcitation and pressor response in conscious female rats.

Authors:  Fanrong Yao; Abdel A Abdel-Rahman
Journal:  Biochem Pharmacol       Date:  2022-05-23       Impact factor: 6.100

Review 3.  Withdrawal of prenylamine: perspectives on pharmacological, clinical and regulatory outcomes following the first QT-related casualty.

Authors:  Rashmi R Shah; Peter D Stonier
Journal:  Ther Adv Drug Saf       Date:  2018-06-18

4.  Sex- and Gender-Based Pharmacological Response to Drugs.

Authors:  Franck Mauvais-Jarvis; Heiner K Berthold; Ilaria Campesi; Juan-Jesus Carrero; Santosh Dakal; Flavia Franconi; Ioanna Gouni-Berthold; Mark L Heiman; Alexandra Kautzky-Willer; Sabra L Klein; Anne Murphy; Vera Regitz-Zagrosek; Karen Reue; Joshua B Rubin
Journal:  Pharmacol Rev       Date:  2021-04       Impact factor: 25.468

5.  Sex differences in pharmacokinetics predict adverse drug reactions in women.

Authors:  Irving Zucker; Brian J Prendergast
Journal:  Biol Sex Differ       Date:  2020-06-05       Impact factor: 5.027

Review 6.  Sex and the kidneys: current understanding and research opportunities.

Authors:  C Noel Bairey Merz; Laura M Dember; Julie R Ingelfinger; Amanda Vinson; Joel Neugarten; Kathryn L Sandberg; Jennifer C Sullivan; Christine Maric-Bilkan; Tracy L Rankin; Paul L Kimmel; Robert A Star
Journal:  Nat Rev Nephrol       Date:  2019-10-04       Impact factor: 28.314

7.  Restoration of Adiponectin-Connexin43 Signaling Mitigates Myocardial Inflammation and Dysfunction in Diabetic Female Rats.

Authors:  Korin E Leffler; Abdel A Abdel-Rahman
Journal:  J Cardiovasc Pharmacol       Date:  2020-03       Impact factor: 3.271

8.  Development of a Predictive Model to Induce Atherogenesis and Hepato-Renal Impairment in Female Rats.

Authors:  Lucas Pires Guarnier; Paulo Vitor Moreira Romão; Rhanany Alan Calloi Palozi; Aniely Oliveira Silva; Bethânia Rosa Lorençone; Aline Aparecida Macedo Marques; Ariany Carvalho Dos Santos; Roosevelt Isaias Carvalho Souza; Karine Delgado Souza; Emerson Luiz Botelho Lourenço; Arquimedes Gasparotto Junior
Journal:  Biomolecules       Date:  2019-10-29

9.  Atheroprotective Properties of Costus spicatus (Jacq.) Sw. in Female Rats.

Authors:  Bethânia Rosa Lorençone; Lucas Pires Guarnier; Rhanany Alan Calloi Palozi; Paulo Vitor Moreira Romão; Aline Aparecida Macedo Marques; Lislaine Maria Klider; Roosevelt Isaias Carvalho Souza; Ariany Carvalho Dos Santos; Cleide Adriane Signor Tirloni; Nadla Soares Cassemiro; Denise Brentan Silva; Jane Manfron Budel; Arquimedes Gasparotto Junior
Journal:  Life (Basel)       Date:  2021-03-08
  9 in total

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