| Literature DB >> 33653873 |
Franck Mauvais-Jarvis1, Heiner K Berthold2, Ilaria Campesi2, Juan-Jesus Carrero2, Santosh Dakal2, Flavia Franconi2, Ioanna Gouni-Berthold2, Mark L Heiman2, Alexandra Kautzky-Willer2, Sabra L Klein2, Anne Murphy2, Vera Regitz-Zagrosek2, Karen Reue2, Joshua B Rubin2.
Abstract
In humans, the combination of all sex-specific genetic, epigenetic, and hormonal influences of biologic sex produces different in vivo environments for male and female cells. We dissect how these influences of sex modify the pharmacokinetics and pharmacodynamics of multiple drugs and provide examples for common drugs acting on specific organ systems. We also discuss how gender of physicians and patients may influence the therapeutic response to drugs. We aim to highlight sex as a genetic modifier of the pharmacological response to drugs, which should be considered as a necessary step toward precision medicine that will benefit men and women. SIGNIFICANCE STATEMENT: This study discusses the influences of biologic sex on the pharmacokinetics and pharmacodynamics of drugs and provides examples for common drugs acting on specific organ systems. This study also discusses how gender of physicians and patients influence the therapeutic response to drugs.Entities:
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Year: 2021 PMID： 33653873 PMCID： PMC7938661 DOI： 10.1124/pharmrev.120.000206
Source DB: PubMed Journal: Pharmacol Rev ISSN： 0031-6997 Impact factor: 25.468