Literature DB >> 28338410

Intracellular delivery of proteins by nanocarriers.

Moumita Ray1, Yi-Wei Lee1, Federica Scaletti1, Ruijin Yu1,2, Vincent M Rotello1.   

Abstract

Intracellular delivery of proteins is potentially a game-changing approach for therapeutics. However, for most applications, the protein needs to access the cytosol to be effective. A wide variety of strategies have been developed for protein delivery, however access of delivered protein to the cytosol without acute cytotoxicity remains a critical issue. In this review we discuss recent trends in protein delivery using nanocarriers, focusing on the ability of these strategies to deliver protein into the cytosol.

Entities:  

Keywords:  cytosolic delivery; nanoparticle-stabilized nanocapsules; nuclear targeting; protein; punctate fluorescence

Mesh：

Substances：

Year:  2017        PMID： 28338410      PMCID： PMC5829369          DOI： 10.2217/nnm-2016-0393

Source DB:  PubMed          Journal:  Nanomedicine (Lond)        ISSN： 1743-5889            Impact factor:   5.307


  57 in total

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3.  Fusogenic Liposomes as Nanocarriers for the Delivery of Intracellular Proteins.

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Review 4.  Polysaccharide nanoparticles for protein and Peptide delivery: exploring less-known materials.

Authors:  Marlise A dos Santos; Ana Grenha
Journal:  Adv Protein Chem Struct Biol       Date:  2015-03-03       Impact factor: 3.507

5.  Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles.

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Journal:  Proc Natl Acad Sci U S A       Date:  2016-02-29       Impact factor: 11.205

6.  Intracellular delivery of proteins in complexes with oligoarginine-modified liposomes and the effect of oligoarginine length.

Authors:  Masahiko Furuhata; Hiroko Kawakami; Kazunori Toma; Yoshiyuki Hattori; Yoshie Maitani
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Review 7.  Nanocarriers as an emerging platform for cancer therapy.

Authors:  Dan Peer; Jeffrey M Karp; Seungpyo Hong; Omid C Farokhzad; Rimona Margalit; Robert Langer
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8.  Mammalian cell penetration, siRNA transfection, and DNA transfection by supercharged proteins.

Authors:  Brian R McNaughton; James J Cronican; David B Thompson; David R Liu
Journal:  Proc Natl Acad Sci U S A       Date:  2009-03-23       Impact factor: 11.205

Review 9.  Gene therapy for cancer: present status and future perspective.

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Journal:  Mol Cell Ther       Date:  2014-09-10

10.  Protein delivery into live cells by incubation with an endosomolytic agent.

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Journal:  Nat Methods       Date:  2014-06-15       Impact factor: 28.547
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  20 in total

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Review 2.  Protein delivery into cells using inorganic nanoparticle-protein supramolecular assemblies.

Authors:  Federica Scaletti; Joseph Hardie; Yi-Wei Lee; David C Luther; Moumita Ray; Vincent M Rotello
Journal:  Chem Soc Rev       Date:  2018-05-21       Impact factor: 54.564

Review 3.  The potential of engineered eukaryotic RNA-binding proteins as molecular tools and therapeutics.

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Journal:  J Am Chem Soc       Date:  2018-05-24       Impact factor: 15.419

Review 5.  Accessing Intracellular Targets through Nanocarrier-Mediated Cytosolic Protein Delivery.

Authors:  Ritabrita Goswami; Taewon Jeon; Harini Nagaraj; Shumei Zhai; Vincent M Rotello
Journal:  Trends Pharmacol Sci       Date:  2020-09-02       Impact factor: 14.819

6.  Mapping Molecular Structure of Protein Locating on Nanoparticles with Limited Proteolysis.

Authors:  Yaokai Duan; Yang Liu; Roxana Coreas; Wenwan Zhong
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Review 7.  Delivery technologies for in utero gene therapy.

Authors:  Rohan Palanki; William H Peranteau; Michael J Mitchell
Journal:  Adv Drug Deliv Rev       Date:  2020-11-09       Impact factor: 15.470

8.  Coiled coil exposure and histidine tags drive function of an intracellular protein drug carrier.

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Review 9.  Cyclodextrins-Peptides/Proteins Conjugates: Synthesis, Properties and Applications.

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Review 10.  Microfluidic Based Physical Approaches towards Single-Cell Intracellular Delivery and Analysis.

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