Hassan Hashemi1,2, Mehdi Khabazkhoob3, AbbasAli Yekta4, Mohammad Hassan Emamian5, Payam Nabovati2, Akbar Fotouhi6. 1. a Noor Research Center for Ophthalmic Epidemiology, Noor Eye Hospital , Tehran , Iran. 2. b Noor Ophthalmology Research Center, Noor Eye Hospital , Tehran , Iran. 3. c Department of Medical Surgical Nursing, School of Nursing and Midwifery , Shahid Beheshti University of Medical Sciences , Tehran , Iran. 4. d Department of Optometry, School of Paramedical Sciences , Mashhad University of Medical Sciences , Mashhad , Iran. 5. e Center for Health Related Social and Behavioral Sciences Research , Shahroud University of Medical Sciences , Shahroud , Iran. 6. f Department of Epidemiology and Biostatistics, School of Public Health , Tehran University of Medical Sciences , Tehran , Iran.
Abstract
PURPOSE: To determine the distribution of macular thickness in a healthy Iranian population aged 45-69 years and its association with certain determinants. METHODS: All participants underwent optometric examinations including measurement of uncorrected and corrected visual acuity, objective refraction by retinoscopy, and subjective refraction. Subsequently, all participants underwent slit-lamp biomicroscopy followed by fundus examination through direct and indirect ophthalmoscopy, and optical coherence tomography (OCT) imaging under pupil dilation. RESULTS: Mean central macular thickness was 255.4 µm (95% confidence interval, CI, 254.5-256.3 µm), average inner macular thickness was 316.5 µm (95% CI 315.9-317.1 µm), average outer macular thickness was 275.3 µm (95% CI 274.8-275.8 µm), and overall average thickness was 278.6 µm (95% CI 278.1-279.1 µm). A linear multiple regression model showed that all indexes were significantly larger in male participants (p < 0.001). Central macular thickness increased with age (coef = 0.25, p < 0.001) while overall, inner and outer macular thickness decreased with age (coef = -0.18, -0.15, -0.19, respectively, all p < 0.001). Central and inner macular thickness had a positive correlation (coef = 3.8, 2.6, respectively, both p < 0.001) and outer macular thickness had a negative correlation (coef = -1.6, p < 0.001) with axial length. CONCLUSION: Age, sex, refractive error, axial length, and keratometry were found to be associated with macular thickness. These factors should be taken into account when interpreting macular thickness measurements with spectral-domain OCT.
PURPOSE: To determine the distribution of macular thickness in a healthy Iranian population aged 45-69 years and its association with certain determinants. METHODS: All participants underwent optometric examinations including measurement of uncorrected and corrected visual acuity, objective refraction by retinoscopy, and subjective refraction. Subsequently, all participants underwent slit-lamp biomicroscopy followed by fundus examination through direct and indirect ophthalmoscopy, and optical coherence tomography (OCT) imaging under pupil dilation. RESULTS: Mean central macular thickness was 255.4 µm (95% confidence interval, CI, 254.5-256.3 µm), average inner macular thickness was 316.5 µm (95% CI 315.9-317.1 µm), average outer macular thickness was 275.3 µm (95% CI 274.8-275.8 µm), and overall average thickness was 278.6 µm (95% CI 278.1-279.1 µm). A linear multiple regression model showed that all indexes were significantly larger in male participants (p < 0.001). Central macular thickness increased with age (coef = 0.25, p < 0.001) while overall, inner and outer macular thickness decreased with age (coef = -0.18, -0.15, -0.19, respectively, all p < 0.001). Central and inner macular thickness had a positive correlation (coef = 3.8, 2.6, respectively, both p < 0.001) and outer macular thickness had a negative correlation (coef = -1.6, p < 0.001) with axial length. CONCLUSION: Age, sex, refractive error, axial length, and keratometry were found to be associated with macular thickness. These factors should be taken into account when interpreting macular thickness measurements with spectral-domain OCT.
Authors: Kotaro Tsuboi; Qi Sheng You; Yukun Guo; Jie Wang; Christina J Flaxel; Steven T Bailey; David Huang; Yali Jia; Thomas S Hwang Journal: Am J Ophthalmol Date: 2021-12-21 Impact factor: 5.258
Authors: Bhim B Rai; Faran Sabeti; Corinne F Carle; Emilie M Rohan; Josh P van Kleef; Rohan W Essex; Richard C Barry; Ted Maddess Journal: Ophthalmol Sci Date: 2022-03-18