Literature DB >> 28332132

Redefining the role of biomarkers in heart failure trials: expert consensus document.

Frank Kramer1, Hani N Sabbah2, James J Januzzi3, Faiez Zannad4, J Peter van Tintelen5, Erik B Schelbert6, Raymond J Kim7, Hendrik Milting8, Richardus Vonk9, Brien Neudeck10, Richard Clark10, Klaus Witte11, Wilfried Dinh12, Burkert Pieske13,14,15, Javed Butler16, Mihai Gheorghiade17.   

Abstract

Heart failure is a growing cardiovascular disease with significant epidemiological, clinical, and societal implications and represents a high unmet need. Strong efforts are currently underway by academic and industrial researchers to develop novel treatments for heart failure. Biomarkers play an important role in patient selection and monitoring in drug trials and in clinical management. The present review gives an overview of the role of available molecular, imaging, and device-derived digital biomarkers in heart failure drug development and highlights capabilities and limitations of biomarker use in this context.

Entities:  

Keywords:  Biomarker; Clinical trial; Drug development; Heart failure; Imaging; Medical device

Mesh：

Substances：

Year:  2017        PMID： 28332132     DOI： 10.1007/s10741-017-9608-5

Source DB:  PubMed          Journal:  Heart Fail Rev        ISSN： 1382-4147            Impact factor:   4.214


  93 in total

1.  Prognostic factors versus predictive factors: Examples from a clinical trial of erlotinib.

Authors:  Gary M Clark
Journal:  Mol Oncol       Date:  2007-12-08       Impact factor: 6.603

2.  Lisinopril-mediated regression of myocardial fibrosis in patients with hypertensive heart disease.

Authors:  C G Brilla; R C Funck; H Rupp
Journal:  Circulation       Date:  2000-09-19       Impact factor: 29.690

3.  Harnessing the heart of big data.

Authors:  Sarah B Scruggs; Karol Watson; Andrew I Su; Henning Hermjakob; John R Yates; Merry L Lindsey; Peipei Ping
Journal:  Circ Res       Date:  2015-03-27       Impact factor: 17.367

4.  A genome-wide association study of a coronary artery disease risk variant.

Authors:  Ji-Young Lee; Bok-Soo Lee; Dong-Jik Shin; Kyung Woo Park; Young-Ah Shin; Kwang Joong Kim; Lyong Heo; Ji Young Lee; Yun Kyoung Kim; Young Jin Kim; Chang Bum Hong; Sang-Hak Lee; Dankyu Yoon; Hyo Jung Ku; Il-Young Oh; Bong-Jo Kim; Juyoung Lee; Seon-Joo Park; Jimin Kim; Hye-Kyung Kawk; Jong-Eun Lee; Hye-Kyung Park; Jae-Eun Lee; Hye-Young Nam; Hyun-Young Park; Chol Shin; Mitsuhiro Yokota; Hiroyuki Asano; Masahiro Nakatochi; Tatsuaki Matsubara; Hidetoshi Kitajima; Ken Yamamoto; Hyung-Lae Kim; Bok-Ghee Han; Myeong-Chan Cho; Yangsoo Jang; Hyo-Soo Kim; Jeong Euy Park; Jong-Young Lee
Journal:  J Hum Genet       Date:  2013-01-31       Impact factor: 3.172

5.  Insulin-Like Growth Factor-Binding Protein-7 as a Biomarker of Diastolic Dysfunction and Functional Capacity in Heart Failure With Preserved Ejection Fraction: Results From the RELAX Trial.

Authors:  Parul U Gandhi; Hanna K Gaggin; Margaret M Redfield; Horng H Chen; Susanna R Stevens; Kevin J Anstrom; Marc J Semigran; Peter Liu; James L Januzzi
Journal:  JACC Heart Fail       Date:  2016-10-12       Impact factor: 12.035

6.  Combined heart failure device diagnostics identify patients at higher risk of subsequent heart failure hospitalizations: results from PARTNERS HF (Program to Access and Review Trending Information and Evaluate Correlation to Symptoms in Patients With Heart Failure) study.

Authors:  David J Whellan; Kevin T Ousdigian; Sana M Al-Khatib; Wenji Pu; Shantanu Sarkar; Charles B Porter; Behzad B Pavri; Christopher M O'Connor
Journal:  J Am Coll Cardiol       Date:  2010-04-27       Impact factor: 24.094

7.  The biomarker plasma galectin-3 in advanced heart failure and survival with mechanical circulatory support devices.

Authors:  Gülsüm Erkilet; Cenk Özpeker; Dietmar Böthig; Frank Kramer; Daniela Röfe; Birte Bohms; Michiel Morshuis; Jan Gummert; Hendrik Milting
Journal:  J Heart Lung Transplant       Date:  2013-02       Impact factor: 10.247

8.  Diffuse myocardial fibrosis evaluation using cardiac magnetic resonance T1 mapping: sample size considerations for clinical trials.

Authors:  Songtao Liu; Jing Han; Marcelo S Nacif; Jacquin Jones; Nadine Kawel; Peter Kellman; Christopher T Sibley; David A Bluemke
Journal:  J Cardiovasc Magn Reson       Date:  2012-12-28       Impact factor: 5.364

9.  T1 mapping of the myocardium: intra-individual assessment of post-contrast T1 time evolution and extracellular volume fraction at 3T for Gd-DTPA and Gd-BOPTA.

Authors:  Nadine Kawel; Marcelo Nacif; Anna Zavodni; Jacquin Jones; Songtao Liu; Christopher T Sibley; David A Bluemke
Journal:  J Cardiovasc Magn Reson       Date:  2012-04-28       Impact factor: 5.364

10.  Myocardial extravascular extracellular volume fraction measurement by gadolinium cardiovascular magnetic resonance in humans: slow infusion versus bolus.

Authors:  Erik B Schelbert; Stephen M Testa; Christopher G Meier; William J Ceyrolles; Joshua E Levenson; Alexander J Blair; Peter Kellman; Bobby L Jones; Daniel R Ludwig; David Schwartzman; Sanjeev G Shroff; Timothy C Wong
Journal:  J Cardiovasc Magn Reson       Date:  2011-03-04       Impact factor: 5.364
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  5 in total

1.  IL-1 Blockade in Patients With Heart Failure With Preserved Ejection Fraction.

Authors:  Benjamin W Van Tassell; Cory R Trankle; Justin M Canada; Salvatore Carbone; Leo Buckley; Dinesh Kadariya; Marco G Del Buono; Hayley Billingsley; George Wohlford; Michele Viscusi; Claudia Oddi-Erdle; Nayef A Abouzaki; Dave Dixon; Giuseppe Biondi-Zoccai; Ross Arena; Antonio Abbate
Journal:  Circ Heart Fail       Date:  2018-08       Impact factor: 8.790

Review 2.  Using EEG-Guided Basket and Umbrella Trials in Psychiatry: A Precision Medicine Approach for Cognitive Impairment in Schizophrenia.

Authors:  Yash B Joshi; Gregory A Light
Journal:  Front Psychiatry       Date:  2018-11-19       Impact factor: 4.157

3.  Information and Communication Technologies, a Promising Way to Support Pharmacotherapy for the Behavioral and Psychological Symptoms of Dementia.

Authors:  Antoine Piau; Pierre Rumeau; Fati Nourhashemi; Maria Soto Martin
Journal:  Front Pharmacol       Date:  2019-09-30       Impact factor: 5.810

Review 4.  Clinical Evidence for Q10 Coenzyme Supplementation in Heart Failure: From Energetics to Functional Improvement.

Authors:  Anna Di Lorenzo; Gabriella Iannuzzo; Alessandro Parlato; Gianluigi Cuomo; Crescenzo Testa; Marta Coppola; Giuseppe D'Ambrosio; Domenico Alessandro Oliviero; Silvia Sarullo; Giuseppe Vitale; Cinzia Nugara; Filippo M Sarullo; Francesco Giallauria
Journal:  J Clin Med       Date:  2020-04-27       Impact factor: 4.241

5.  Identification of Prognostic Biomarkers by Combined mRNA and miRNA Expression Microarray Analysis in Pancreatic Cancer.

Authors:  Bin Liu; Hai Yang; Leila Taher; Axel Denz; Robert Grützmann; Christian Pilarsky; Georg F Weber
Journal:  Transl Oncol       Date:  2018-04-06       Impact factor: 4.243
  5 in total

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